Pesquisa | Portal de Pesquisa da BVS

1.

Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters.

Mulka, Kathleen R; Beck, Sarah E; Solis, Clarisse V; Johanson, Andrew L; Queen, Suzanne E; McCarron, Megan E; Richardson, Morgan R; Zhou, Ruifeng; Marinho, Paula; Jedlicka, Anne; Guerrero-Martin, Selena; Shirk, Erin N; Braxton, Alicia M; Brockhurst, Jacqueline; Creisher, Patrick S; Dhakal, Santosh; Brayton, Cory F; Veenhuis, Rebecca T; Metcalf Pate, Kelly A; Karakousis, Petros C; Zahnow, Cynthia A; Klein, Sabra L; Jain, Sanjay K; Tarwater, Patrick M; Pekosz, Andrew S; Villano, Jason S; Mankowski, Joseph L.

Am J Pathol ; 192(2): 195-207, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34767812

2.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal, Anup; Parai, Maloy K; Shetty, Nishant; Wallis, Deeann; Woolhiser, Lisa; Hastings, Courtney; Dutta, Noton K; Galaviz, Stacy; Dhakal, Ramesh C; Shrestha, Rupesh; Wakabayashi, Shoko; Walpole, Chris; Matthews, David; Floyd, David; Scullion, Paul; Riley, Jennifer; Epemolu, Ola; Norval, Suzanne; Snavely, Thomas; Robertson, Gregory T; Rubin, Eric J; Ioerger, Thomas R; Sirgel, Frik A; van der Merwe, Ruben; van Helden, Paul D; Keller, Peter; Böttger, Erik C; Karakousis, Petros C; Lenaerts, Anne J; Sacchettini, James C.

Cell ; 170(2): 249-259.e25, 2017 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-28669536

3.

Mycobacterium tuberculosis Infection Drives Mitochondria-Biased Dysregulation of Host Transfer RNA-Derived Fragments.

Looney, Monika M; Lu, Yin; Karakousis, Petros C; Halushka, Marc K.

J Infect Dis ; 223(10): 1796-1805, 2021 05 28.

Artigo em Inglês | MEDLINE | ID: mdl-32959876

4.

The Impact of Hypertension and Use of Calcium Channel Blockers on Tuberculosis Treatment Outcomes.

Chidambaram, Vignesh; Gupte, Akshay; Wang, Jann-Yuan; Golub, Jonathan E; Karakousis, Petros C.

Clin Infect Dis ; 73(9): e3409-e3418, 2021 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-32971534

5.

Male Sex Is Associated With Worse Microbiological and Clinical Outcomes Following Tuberculosis Treatment: A Retrospective Cohort Study, a Systematic Review of the Literature, and Meta-analysis.

Chidambaram, Vignesh; Tun, Nyan Lynn; Majella, Marie Gilbert; Ruelas Castillo, Jennie; Ayeh, Samuel K; Kumar, Amudha; Neupane, Pranita; Sivakumar, Ranjith Kumar; Win, Ei Phyo; Abbey, Enoch J; Wang, Siqing; Zimmerman, Alyssa; Blanck, Jaime; Gupte, Akshay; Wang, Jann-Yuan; Karakousis, Petros C.

Clin Infect Dis ; 73(9): 1580-1588, 2021 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-34100919

6.

Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions.

Zhou, Lucas; Ayeh, Samuel K; Chidambaram, Vignesh; Karakousis, Petros C.

BMC Infect Dis ; 21(1): 496, 2021 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-34049515

7.

Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.

Dutta, Noton K; Bruiners, Natalie; Zimmerman, Matthew D; Tan, Shumin; Dartois, Véronique; Gennaro, Maria L; Karakousis, Petros C.

J Infect Dis ; 221(7): 1079-1087, 2020 03 16.

Artigo em Inglês | MEDLINE | ID: mdl-31605489

8.

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis.

Bruiners, Natalie; Dutta, Noton K; Guerrini, Valentina; Salamon, Hugh; Yamaguchi, Ken D; Karakousis, Petros C; Gennaro, Maria L.

J Lipid Res ; 61(12): 1617-1628, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32848049

9.

Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine melanoma model.

Gordy, James T; Luo, Kun; Kapoor, Aakanksha; Kim, Emily S; Ayeh, Samuel K; Karakousis, Petros C; Markham, Richard B.

Cancer Immunol Immunother ; 69(4): 569-580, 2020 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-31980915

10.

Stability and Viability of SARS-CoV-2.

Rubens, Jessica H; Karakousis, Petros C; Jain, Sanjay K.

N Engl J Med ; 382(20): 1962-1963, 2020 05 14.

Artigo em Inglês | MEDLINE | ID: mdl-32283575

11.

Reply to Lai et al.

Chidambaram, Vignesh; Karakousis, Petros C.

J Infect Dis ; 224(7): 1269-1270, 2021 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-33580262

12.

Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?

Dutta, Noton K; Karakousis, Petros C.

J Infect Dis ; 222(2): 336-337, 2020 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-31872863

13.

Association of Lipid Levels With COVID-19 Infection, Disease Severity and Mortality: A Systematic Review and Meta-Analysis.

Chidambaram, Vignesh; Shanmugavel Geetha, Harinivaas; Kumar, Amudha; Majella, Marie Gilbert; Sivakumar, Ranjith Kumar; Voruganti, Dinesh; Mehta, Jawahar L; Karakousis, Petros C.

Front Cardiovasc Med ; 9: 862999, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35402531

14.

Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment.

Danchik, Carina; Wang, Siqing; Karakousis, Petros C.

Front Microbiol ; 12: 744167, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34690990

15.

Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation.

Looney, Monika; Lorenc, Rachel; Halushka, Marc K; Karakousis, Petros C.

Front Immunol ; 12: 685237, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34140955

16.

Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium.

Matern, William M; Parker, Harley; Danchik, Carina; Hoover, Leah; Bader, Joel S; Karakousis, Petros C.

Microbiol Spectr ; 9(2): e0024621, 2021 10 31.

Artigo em Inglês | MEDLINE | ID: mdl-34523947

17.

Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis.

Chuang, Yu-Min; He, Liangmei; Pinn, Michael L; Tsai, Ya-Chea; Cheng, Max A; Farmer, Emily; Karakousis, Petros C; Hung, Chien-Fu.

Cell Mol Immunol ; 18(10): 2393-2401, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-32382128

18.

The association of atherosclerotic cardiovascular disease and statin use with inflammation and treatment outcomes in tuberculosis.

Chidambaram, Vignesh; Ruelas Castillo, Jennie; Kumar, Amudha; Wei, Justin; Wang, Siqing; Majella, Marie Gilbert; Gupte, Akshay; Wang, Jann-Yuan; Karakousis, Petros C.

Sci Rep ; 11(1): 15283, 2021 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-34315941

19.

Higher Serum Cholesterol Levels Are Associated With Reduced Systemic Inflammation and Mortality During Tuberculosis Treatment Independent of Body Mass Index.

Chidambaram, Vignesh; Zhou, Lucas; Ruelas Castillo, Jennie; Kumar, Amudha; Ayeh, Samuel K; Gupte, Akshay; Wang, Jann-Yuan; Karakousis, Petros C.

Front Cardiovasc Med ; 8: 696517, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34239907

20.

The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children.

Tornheim, Jeffrey A; Paradkar, Mandar; Zhao, Henry; Kulkarni, Vandana; Pradhan, Neeta; Kinikar, Aarti; Kagal, Anju; Gupte, Nikhil; Mave, Vidya; Gupta, Amita; Karakousis, Petros C.

Front Immunol ; 12: 774043, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-35095848

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