Pesquisa | Portal de Pesquisa da BVS

1.

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

Mahon, Brian P; Ambadapadi, Sriram; Yaron, Jordan R; Lomelino, Carrie L; Pinard, Melissa A; Keinan, Shahar; Kurnikov, Igor; Macaulay, Colin; Zhang, Liqiang; Reeves, Westley; McFadden, Grant; Tibbetts, Scott; McKenna, Robert; Lucas, Alexandra R.

Biochemistry ; 57(7): 1096-1107, 2018 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-29227673

2.

Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvß6 integrin-deficient mice.

Velsko, Irina M; Chukkapalli, Sasanka S; Rivera-Kweh, Mercedes F; Zheng, Donghang; Aukhil, Ikramuddin; Lucas, Alexandra R; Larjava, Hannu; Kesavalu, Lakshmyya.

Infect Immun ; 83(12): 4582-93, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26371120

3.

Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.

Chukkapalli, Sasanka S; Rivera, Mercedes F; Velsko, Irina M; Lee, Ju-Youn; Chen, Hao; Zheng, Donghang; Bhattacharyya, Indraneel; Gangula, Pandu R; Lucas, Alexandra R; Kesavalu, Lakshmyya.

Infect Immun ; 82(5): 1959-67, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24566627

4.

Myxomavirus Serp-1 Protein Ameliorates Inflammation in a Mouse Model of Duchenne Muscular Dystrophy.

Andre, Alexander B; Zhang, Liqiang; Nix, Jalen D; Elmadbouly, Nora; Lucas, Alexandra R; Wilson-Rawls, Jeanne; Rawls, Alan.

Biomedicines ; 10(5)2022 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-35625891

5.

Systemic Delivery of mLIGHT-Armed Myxoma Virus Is Therapeutic for Later-Stage Syngeneic Murine Lung Metastatic Osteosarcoma.

Christie, John D; Appel, Nicole; Zhang, Liqiang; Lowe, Kenneth; Kilbourne, Jacquelyn; Daggett-Vondras, Juliane; Elliott, Natalie; Lucas, Alexandra R; Blattman, Joseph N; Rahman, Masmudur M; McFadden, Grant.

Cancers (Basel) ; 14(2)2022 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-35053501

6.

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study.

Varkoly, Kyle; Tan, Shaoyuan; Beladi, Roxana; Fonseca, David; Zanetti, Isabela Rivabem; Kraberger, Simona; Shah, Chintan; Yaron, Jordan R; Zhang, Liqiang; Juby, Michael; Fath, Ayman; Ambadapadi, Sriram; House, Melanie; Maranian, Paul; Pepine, Carl J; Varsani, Arvind; Moreb, Jan; Schultz-Cherry, Stacey; Lucas, Alexandra R.

Front Cardiovasc Med ; 9: 821162, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35360008

7.

The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury.

Kwiecien, Jacek M; Dabrowski, Wojciech; Yaron, Jordan R; Zhang, Liqiang; Delaney, Kathleen H; Lucas, Alexandra R.

Curr Neuropharmacol ; 19(2): 294-303, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-32691715

8.

Neurologic and Histologic Tests Used to Measure Neuroprotective Effectiveness of Virus-Derived Immune-Modulating Proteins.

Kwiecien, Jacek M; Yaron, Jordan R; Delaney, Kathleen H; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 227-239, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108666

9.

A Mouse Model of Acute Liver Injury by Warm, Partial Ischemia-Reperfusion for Testing the Efficacy of Virus-Derived Therapeutics.

Yaron, Jordan R; Zhang, Liqiang; Guo, Qiuyun; Chen, Hao; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 275-292, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108669

10.

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms.

Yaron, Jordan R; Zhang, Liqiang; Guo, Qiuyun; Haydel, Shelley E; Lucas, Alexandra R.

Front Cardiovasc Med ; 8: 648947, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33869309

11.

Preclinical Testing of Viral Therapeutic Efficacy in Pristane-Induced Lupus Nephritis and Diffuse Alveolar Hemorrhage Mouse Models.

Guo, Qiuyun; Zhang, Liqiang; Yaron, Jordan R; Burgin, Michelle; Schutz, Lauren N; Awo, Enkidia A; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 241-255, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108667

12.

Kidney Subcapsular Allograft Transplants as a Model to Test Virus-Derived Chemokine-Modulating Proteins as Therapeutics.

Burgin, Michelle; Yaron, Jordan R; Zhang, Liqiang; Guo, Qiuyun; Daggett, Juliane; Kilbourne, Jacquelyn; Lowe, Kenneth M; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 257-273, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108668

13.

Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins).

Yaron, Jordan R; Zhang, Liqiang; Burgin, Michelle; Schutz, Lauren N; Awo, Enkidia A; Keinan, Shahar; McFadden, Grant; Ambadapadi, Sriram; Guo, Qiuyun; Chen, Hao; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 107-123, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108660

14.

Topical Application of Virus-Derived Immunomodulating Proteins and Peptides to Promote Wound Healing in Mouse Models.

Zhang, Liqiang; Yaron, Jordan R; Guo, Qiuyun; Kilbourne, Jacquelyn; Awo, Enkidia A; Burgin, Michelle; Schutz, Lauren N; Wallace, Sarah E; Lowe, Kenneth M; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 217-226, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108665

15.

Distinct Coagulopathy With Myocardial Injury and Pulmonary Embolism in COVID-19.

Fath, Ayman R; Aglan, Amro; Varkoly, Kyle S; Eldaly, Abdullah S; Beladi, Roxana N; Forlemu, Arnold; Mihyawi, Nawfal; Solsi, Anup; Israr, Sharjeel; Lucas, Alexandra R.

J Investig Med High Impact Case Rep ; 9: 23247096211019559, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34036814

16.

PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion.

Guo, Qiuyun; Yaron, Jordan R; Wallen, John W; Browder, Kyle F; Boyd, Ryan; Olson, Tien L; Burgin, Michelle; Ulrich, Peaches; Aliskevich, Emily; Schutz, Lauren N; Fromme, Petra; Zhang, Liqiang; Lucas, Alexandra R.

Front Cardiovasc Med ; 8: 633212, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33665212

17.

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Ju, Brent; Guo, Owen; Benissan-Messan, Dathe Z; Shawver, McKinley H; Chen, Peng; Geng, Bingchuan; Wei, Siqi; Yaron, Jordan R; Lucas, Alexandra R; Zhu, Hua.

Front Cardiovasc Med ; 8: 649124, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34164439

18.

Serine Proteases and Chemokines in Neurotrauma: New Targets for Immune Modulating Therapeutics in Spinal Cord Injury.

Beladi, Roxana N; Varkoly, Kyle S; Schutz, Lauren; Zhang, Liqiang; Yaron, Jordan R; Guo, Qiuyun; Burgin, Michelle; Hogue, Ian; Tierney, Wesley; Dobrowski, Wojciech; Lucas, Alexandra R.

Curr Neuropharmacol ; 19(11): 1835-1854, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33632104

19.

Incidental Finding of a Large Right Atrial Thrombus in a Patient With Cerebral Lymphoma.

Fath, Ayman R; Eldaly, Abdullah S; Aglan, Amro; Varkoly, Kyle S; Beladi, Roxana N; Solsi, Anup; Hahn, Mary F; Karis, John P; Nafisi, Sina; Brady, Kevin; Bellamkonda, Pallavi; Wakefield, Dara N; Clapp, William L; Lucas, Alexandra R.

J Investig Med High Impact Case Rep ; 9: 23247096211001636, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33749363

20.

Viral TNF inhibitors as potential therapeutics.

Rahman, Masmudur M; Lucas, Alexandra R; McFadden, Grant.

Adv Exp Med Biol ; 666: 64-77, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-20054975

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