Pesquisa | Portal de Pesquisa da BVS

1.

Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.

Wakeman, Dustin R; Weed, Michael R; Perez, Sylvia E; Cline, Erika N; Viola, Kirsten L; Wilcox, Kyle C; Moddrelle, David S; Nisbett, Ernell Z; Kurian, Anish M; Bell, Amanda F; Pike, Ricaldo; Jacobson, Peer B; Klein, William L; Mufson, Elliott J; Lawrence, Matthew S; Elsworth, John D.

Neuropathol Appl Neurobiol ; 48(4): e12800, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35156715

2.

Differential diagnosis of a ring-enhancing brain lesion in the setting of metastatic cancer and a mycotic aneurysm.

Tran, Daniel; Rahman, Qasim; Weed, Michael; Chow, Bernard.

Radiol Case Rep ; 16(12): 3850-3854, 2021 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-34745401

3.

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.

Bristow, Linda J; Gulia, Jyoti; Weed, Michael R; Srikumar, Bettadapura N; Li, Yu-Wen; Graef, John D; Naidu, Pattipati S; Sanmathi, Charulatha; Aher, Jayant; Bastia, Tanmaya; Paschapur, Mahesh; Kalidindi, Narasimharaju; Kumar, Kuchibhotla Vijaya; Molski, Thaddeus; Pieschl, Rick; Fernandes, Alda; Brown, Jeffrey M; Sivarao, Digavalli V; Newberry, Kimberly; Bookbinder, Mark; Polino, Joseph; Keavy, Deborah; Newton, Amy; Shields, Eric; Simmermacher, Jean; Kempson, James; Li, Jianqing; Zhang, Huiping; Mathur, Arvind; Kallem, Raja Reddy; Sinha, Meenakshee; Ramarao, Manjunath; Vikramadithyan, Reeba K; Thangathirupathy, Srinivasan; Warrier, Jayakumar; Islam, Imadul; Bronson, Joanne J; Olson, Richard E; Macor, John E; Albright, Charlie F; King, Dalton; Thompson, Lorin A; Marcin, Lawrence R; Sinz, Michael.

J Pharmacol Exp Ther ; 363(3): 377-393, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-28954811

4.

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis, Martin A; Hunihan, Lisa; Watson, John; Gentles, Robert G; Hu, Shuanghua; Huang, Yazhong; Bronson, Joanne; Macor, John E; Beno, Brett R; Ferrante, Meredith; Hendricson, Adam; Knox, Ronald J; Molski, Thaddeus F; Kong, Yan; Cvijic, Mary Ellen; Rockwell, Kristin L; Weed, Michael R; Cacace, Angela M; Westphal, Ryan S; Alt, Andrew; Brown, Jeffrey M.

J Pharmacol Exp Ther ; 354(3): 340-9, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26109678

5.

Neurobehavioral effects of head-only gamma-radiation exposure in rats.

Hienz, Robert D; Brady, Joseph V; Gooden, Virginia L; Vazquez, Marcelo E; Weed, Michael R.

Radiat Res ; 170(3): 292-8, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18763858

6.

Consistent, high-level ethanol consumption in pig-tailed macaques via a multiple-session, limited-intake, oral self-dosing procedure.

Weed, Michael R; Wilcox, Kristin M; Ator, Nancy A; Hienz, Robert D.

Alcohol Clin Exp Res ; 32(6): 942-51, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18445107

7.

A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.

Han, Dongmei; Holger Försterling, F; Li, Xiaoyan; Deschamps, Jeffrey R; Parrish, Damon; Cao, Hui; Rallapalli, Sundari; Clayton, Terry; Teng, Yun; Majumder, Samarpan; Sankar, Subramaniam; Roth, Bryan L; Sieghart, Werner; Furtmuller, Roman; Rowlett, James K; Weed, Michael R; Cook, James M.

Bioorg Med Chem ; 16(19): 8853-62, 2008 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-18790643

8.

Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models.

Barten, Donna M; Cadelina, Gregory W; Weed, Michael R.

Handb Clin Neurol ; 146: 47-64, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-29110779

9.

Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.

Weed, Michael R; Polino, Joseph; Signor, Laura; Bookbinder, Mark; Keavy, Deborah; Benitex, Yulia; Morgan, Daniel G; King, Dalton; Macor, John E; Zaczek, Robert; Olson, Richard; Bristow, Linda J.

PLoS One ; 12(12): e0187609, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-29261656

10.

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Post-Munson, Debra J; Pieschl, Rick L; Molski, Thaddeus F; Graef, John D; Hendricson, Adam W; Knox, Ronald J; McDonald, Ivar M; Olson, Richard E; Macor, John E; Weed, Michael R; Bristow, Linda J; Kiss, Laszlo; Ahlijanian, Michael K; Herrington, James.

Eur J Pharmacol ; 799: 16-25, 2017 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-28132910

11.

Impaired performance on the object retrieval-detour test of executive function in the SIV/macaque model of AIDS.

Gray, Rachel A; Wilcox, Kristin M; Zink, M Christine; Weed, Michael R.

AIDS Res Hum Retroviruses ; 22(10): 1031-5, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17067274

12.

Effects of morphine on circadian rhythms of motor activity and body temperature in pig-tailed macaques.

Weed, Michael R; Hienz, Robert D.

Pharmacol Biochem Behav ; 84(3): 487-96, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16860378

13.

The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development.

Keavy, Deborah; Bristow, Linda J; Sivarao, Digavalli V; Batchelder, Margaret; King, Dalton; Thangathirupathy, Srinivasan; Macor, John E; Weed, Michael R.

PLoS One ; 11(4): e0152729, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27035340

14.

Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains.

Weed, Michael R; Bookbinder, Mark; Polino, Joseph; Keavy, Deborah; Cardinal, Rudolf N; Simmermacher-Mayer, Jean; Cometa, Fu-ni L; King, Dalton; Thangathirupathy, Srinivasan; Macor, John E; Bristow, Linda J.

Neuropsychopharmacology ; 41(2): 568-77, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26105137

15.

Neuropsychopathology in the SIV/macaque model of AIDS.

Weed, Michael R; Steward, David J.

Front Biosci ; 10: 710-27, 2005 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-15569612

16.

Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection.

Weed, Michael R; Gold, Lisa H; Polis, Ilham; Koob, George F; Fox, Howard S; Taffe, Michael A.

AIDS Res Hum Retroviruses ; 20(1): 77-89, 2004 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-15000701

17.

Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys.

Taffe, Michael A; Weed, Michael R; Gutierrez, Tannia; Davis, Sophia A; Gold, Lisa H.

Behav Brain Res ; 149(2): 123-33, 2004 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-15129776

18.

Effects of X-ray radiation on complex visual discrimination learning and social recognition memory in rats.

Davis, Catherine M; Roma, Peter G; Armour, Elwood; Gooden, Virginia L; Brady, Joseph V; Weed, Michael R; Hienz, Robert D.

PLoS One ; 9(8): e104393, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25099152

19.

Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET.

Wilcox, Kristin M; Zhou, Yun; Wong, Dean F; Alexander, Mohab; Rahmim, Arman; Hilton, John; Weed, Michael R.

Synapse ; 62(12): 950-2, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18798297

20.

Cocaine's effects on detection, discrimination, and identification of auditory stimuli by baboons.

Hienz, Robert D; Weed, Michael R; Zarcone, Troy J; Brady, Joseph V.

Pharmacol Biochem Behav ; 74(2): 287-96, 2003 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-12479947

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