Two new compounds from Pergularia tomentosa growing wildly in Jordan.

Phytochemical investigation of the aerial parts and latex of Pergularia tomentosa from Jordan, utilizing column chromatography accompanied with NMR (1 & 2D), IR, UV, and HR-ESI-Mass spectroscopy have led to the isolation and characterization of two new compounds, pergularol (1) and 3-O-acetyl-28-hydroxytaraxasterol (2) for the first time along with other ten known compounds including linoleic acid (3), 3'-didehydroafroside (4), apigenin (5), ß-sitosteryl glucoside (6), luteolin (7), apigenin 7-(6''-crotonoyl)glucoside (8), 3'-O-ß-glucopyranosylcalotropin (9), apigenin-7-O-ß-D-glycoside (10), pergularine A (11), taraxasterol (12). Compound (8) is isolated for the first time from Pergularia genus.