1.
Ann Pharm Fr
; 74(2): 129-36, 2016 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26601885
RESUMO
The topological pressure-temperature phase diagram for the dimorphism of spiperone, a potent neuroleptic drug, has been constructed using literature data and improved crystal structures obtained with new crystallographic data from single-crystal X-ray diffraction at various temperatures. It is inferred that form II, which is the more dense form and exhibits the lower melting temperature, becomes the more stable phase under pressure. Under ambient conditions, form I is more stable.