Digital tracking algorithm reveals the influence of structural irregularities on joint movements in the human cervical spine.

BACKGROUND: Disc height loss and osteophytes change the local mechanical environment in the spine; while previous research has examined kinematic dysfunction under degenerative change, none has looked at the influence of disc height loss and osteophytes throughout movement. METHODS: Twenty patients with pain related to the head, neck or shoulders were imaged via videofluoroscopy as they underwent sagittal-plane flexion and extension. A clinician graded disc height loss and osteophytes as "severe/moderate", "mild", or "none". A novel tracking algorithm quantified motions of each vertebra. This information was used to calculate intervertebral angular and shear displacements. The digital algorithm made it practical to track individual vertebrae in multiple patients through hundreds of images without bias. FINDINGS: Cases without height loss/osteophytes had a consistent increase in intervertebral angular displacement from C2/C3 to C5/C6, like that of healthy individuals, and mild height losses did not produce aberrations that were systematic or necessarily discernable. However, joints with moderate to severe disc height loss and osteophytes exhibited reduced range of motion compared to adjacent unaffected joints in that patient and corresponding joints in patients without structural irregularities. INTERPRETATION: Digitally-obtained motion histories of individual joints allowed anatomical joint changes to be linked with changes in joint movement patterns. Specifically, disc height loss and osteophytes were found to influence cervical spine movement in the sagittal plane, reducing angular motions at affected joints by approximately 10% between those with and without height loss and osteophytes. Further, these joint changes were associated with perturbed intervertebral angular and shear movements.

Disc height loss and restoration via injectable hydrogel influences adjacent segment mechanics in-vitro.

BACKGROUND: Height loss can have a profound influence on the local mechanical environment of the disc. While disc height loss is incorporated into scales of degeneration, its direct influence on spine kinematics is unclear. Further, there is a need for minimally invasive techniques to restore disc height; injectable hydrogels are a potential solution. Tandem investigation of disc height loss and subsequent restoration will enhance understanding of spine dysfunction and aberrant movement. METHODS: Twenty porcine spine specimens with two functional segments were tested in repeated flexion and extension. Relative angular displacement of each segment was measured with full specimen disc height, disc height loss in one of the segments (superior or inferior), and disc height restoration via hydrogel injection. FINDINGS: Disc height loss decreased the range of motion at the affected segment and increased the range of motion at the adjacent segment. Relative angular displacement decreased at the affected segment by 13.8% (SD=5.3%) and 4.5% (SD=2.1%) for specimens with height loss in the superior and inferior discs respectively. Hydrogel injection was able to restore segmental kinematics to the pre-injury state, with 12.7% (SD=5.5%) and 6.4% (SD=4.2%) of motion regained at the affected segment for superior and inferior disc height loss specimens respectively. INTERPRETATION: Acute disc height loss reduces motion at an affected segment, while increasing motion at an adjacent segment in-vitro; relative motion appears to be governed by local stiffness. Injectable hydrogels show promise in their ability to restore kinematics to segments with disc height loss.