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Immunol Lett ; 203: 57-61, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30243945

RESUMO

It is well established that lymphopenia induces the formation of the memory-phenotype T cells without the exposure to foreign antigens. More recently, the memory-phenotype antigen-inexperienced memory T cells were described in lymphoreplete mice and called virtual memory T cells. In this review, we compare multiple aspects of the biology of lymphopenia-induced memory T cells and virtual memory T cells, including cytokine requirements, the role of T-cell receptor specificity in the differentiation process, gene expression signature, and the immune response. Based on this comparison, we conclude that lymphopenia-induced memory T cells and virtual memory T cells most likely represent a single T-cell subset, for which we propose a term 'homeostatic memory T cells'.


Assuntos
Linfócitos T CD8-Positivos/imunologia , Diferenciação Celular/imunologia , Citocinas/imunologia , Memória Imunológica , Linfopenia/imunologia , Modelos Imunológicos , Animais , Linfócitos T CD8-Positivos/patologia , Humanos , Linfopenia/patologia
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