Muscular injury was identified the risk factor of post-operative stenosis after large area but non-circumferential esophageal endoscopic submucosal dissection.

BACKGROUND: The incidence of post-operative stenosis after esophageal Endoscopic Submucosal Dissection (ESD) ranks high. This study aimed to investigate the association between the degree of muscular injury and the incidence of post-operative stenosis. RESEARCH DESIGN: This was a retrospective study of 133 patients with superficial esophageal lesions treated by non-circumferential ESD enrolled between January 2016 and May 2021 at two endoscopy centers. Demographic and clinical parameters were analyzed. A novel muscular injury classification system was proposed. Stenosis risk factors were identified using multivariate logistic regression. The association between the different degrees of muscular injury and the incidence of post-operative stenosis was investigated further by propensity score matching (PSM). RESULTS: There were 133 cases evaluated in this study, 33 of which developed stenosis. Multivariate analysis suggested lesions located in the upper 1/3 of the esophagus, resections >5/6 of the circumference, and muscular injury (Grade 3 or 4 according to our proposed classification) were risk factors for stenosis. Correlation analysis suggested a positive association between the degree of muscular injury and the incidence of post-operative stenosis (r = 0.408, p < .05). For PSM, 29 stenosis cases were matched and univariate analysis further corroborated that muscular injuries of grade 3 (OR = 6.429, 95%CI = 1.318-31.367, p = .021) or 4 (OR = 7, 95%CI = 1.068-45.901, p = .043) were risk factors for stenosis. CONCLUSION: Grade 3-4 muscular injury was identified as a risk factor of post-operative stenosis.

Effects of muscular injuries on the technical and physical performance of professional soccer players.

Introduction: The aim of this study was to determine the effects of muscular injuries in the lower limbs on the technical and physical performance of professional soccer players when they return to the league competition. Methods: Seventy-six muscular injuries incurred by Spanish male professional soccer players (Age: 27.5 ± 3.5 years) were analyzed during two consecutive competitive seasons: 2014-2015 and 2015-2016. The players' performance was studied during Spanish First Division competitive matches using a multi-camera computerized tracking system (Mediacoach Desktop). Results: After muscular injury relative total distance covered in sprints decreased by 8.6 ± 30.2% (P = 0.013) in the first half and 7.7 ± 36.6% (P = 0.038) in the second half. Similarly, maximal running speed decreased by 2.78 ± 6.91 km.h-1 (pre: 27.3 ± 6.4 km.h-1vs. post: 24.5 ± 6.6 km.h-1, P = 0.013) in the first half, and 1.50 ± 5.68 km.h-1 (29.1 ± 3.9 km.h-1vs. 27.6 ± 5.3 km.h-1, P = 0.043) in the second half. Muscle injury also affected technical performance significantly decreasing successful passes (P = 0.045). There were no differences in the number of possession gains (P = 0.277), and possession losses (P = 0.178). Conclusions: After a moderate or severe muscular injury (causing >8 days lay off), player performance is significantly lower in high-intensity efforts and technical skills such as sprints, maximal running speed, or successful passes.

Midkine in repair of the injured nervous system.

UNLABELLED: Midkine (MK) is a growth factor with neurotrophic and neurite outgrowth activities. It was expressed in the peri-ischaemic area in the acute phase of cerebral infarction in rat brains. Astrocytes were the origin of MK in this occasion. MK has been assessed in terms of its effects on neural injury. The administration of MK into the lateral ventricle immediately prior to ischaemia prevented cell death in the hippocampal CA1 neurons degenerated by transient forebrain ischaemia in gerbils. MK administration was also beneficial in rats with neural injury, especially after kainic acid-induced seizures. Gene therapy with mouse MK cDNA using an adenovirus was effective in reducing the cerebral infarction volume and in increasing the number of neuronal precursor cells in the subventricular zone of the rat brain. MK mRNA and MK protein were found in spinal cord motor neurons of the anterior horn in both the acute phase of sciatic nerve injury and 3 weeks later. MK immunoreactivity was also found in the proximal side of a sciatic nerve-injured site in sciatic nerve axons. MK receptors were expressed in Schwann cells after injury, suggesting crosstalk between axons and Schwann cells. MK was also present in nerve terminals and influenced ACh receptor clustering during neuromuscular development in Xenopus. Thus, MK may also be involved in reinforcing and maintaining the synapse. All these findings indicate the therapeutic potential of MK for promoting repair of the nervous system after injury. LINKED ARTICLES: This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-4.

Existe relacao entre o tipo de piso da quadra de futsal e respostas adaptativas da musculatura em praticantes de futsal masculino? / Is there a relationship between the type of floor on futsal courts and musculature adaptive responses of futsal male athletes? / Hay una relacion entre el tipo de piso de la cancha de futbol de salon y las respuestas adaptativas de la usculatura en practicantes de futbol de salon masculino?

INTRODUÇÃO: O futebol de salão (futsal) é atualmente o esporte com maior número de praticantes, tanto no Brasil como nos demais países sul-americanos e também na Europa. É derivado do futebol de campo, adaptado pela falta de espaço para se jogar. Pode ser praticado em três tipos distintos de pisos, rigorosamente nivelados, sem declives nem depressões, prevenindo escorregões e acidentes. A movimentação em quadra exige súbita aceleração e desaceleração com bruscas mudanças de direção, expondo as estruturas osteomioarticulares a grandes impactos, aumentando o risco de lesões, que podem dever-se a fatores intrínsecos ou extrínsecos, nos quais se consideram, entre outras coisas, as condições e o tipo do piso utilizado. OBJETIVO: O propósito deste estudo foi analisar as possíveis influências do tipo de piso utilizado no futsal e as respostas adaptativas musculares em praticantes de futsal masculino. MÉTODOS: A amostra foi composta por 10 praticantes de futsal, de 20 a 30 anos de idade. Através da eletromiografia de superfície, foi realizada a captação da atividade elétrica, por meio da raíz quadrada da média (root mean square - RMS) em µV e da força dos principais grupos musculares do membro inferior dominante em repouso depois de duas partidas de futsal, em dois tipos de pisos de quadras. RESULTADOS: Os achados deste estudo, que envolveu parâmetros biomecânicos utilizados, mostraram não haver diferença significativa entre a prática de futsal na quadra de madeira e na quadra sintética, com tendência de aumento da atividade elétrica da musculatura anterior na quadra com piso de madeira e depois com o piso sintético. CONCLUSÃO: É necessário que se façam maiores in...

INTRODUCTION: Futsal or indoor soccer is currently the sport with the largest number of players in Brazil, other South American countries and also in Europe. It is derived from the soccer played in an outdoor grass field, adapted because of the lack of space to play. It can be practiced in three different types of floors, carefully leveled, without slopes or depressions, preventing slips and accidents. The movement on the court requires sudden acceleration and deceleration with sudden changes of direction, exposing the musculoskeletal structures to major impacts, increasing the risk of injury, which may be due to intrinsic or extrinsic factors, among which we consider the conditions and type of flooring used. OBJECTIVE: The purpose of this study was to analyze the possible influence of the type of flooring used in the indoor soccer courts and the adaptive muscular responses in the male futsal player. METHODS: The sample was composed by 10 indoor soccer players aged 20-30 years old. By surface electromyography, electrical activity was recorded by means of the root mean square (RMS) in microvolts and also the strength of major muscle groups of the dominant leg at rest after two futsal matches in two types of different court floors. RESULTS: The findings of this study of biomechanical parameters showed no significant difference between the practice of futsal in wooden and synthetic courts, with a tendency of increased electrical activity of anterior muscles on the court with a wooden floor and later in the synthetic flooring. CONCLUSION: It is necessary to make further investigations on the possible mechanisms that can reveal musculoskeletal reactions to different types of court flooring in sports like indoor soccer. .

INTRODUCCIÓN: El fútbol de salón es actualmente el deporte con mayor número de participantes, tanto en Brasil como en los demás países sudamericanos y también en Europa. Se deriva del fútbol de campo, adaptado por la falta de espacio para jugarlo. Puede ser practicado sobre tres tipos diferentes de pisos, rigurosamente nivelados, sin declives ni depresiones, previniendo resbalones violentos y accidentes. Los movimientos en la cancha exigen súbitas aceleraciones y desaceleraciones, con cambios bruscos de dirección, exponiendo, a grandes impactos, las estructuras osteomioarticulares, aumentando el riesgo de lesiones que pueden deberse a factores intrínsecos o extrínsecos, en las cuales se consideran, entre otras cosas, las condiciones y el tipo de piso utilizado. OBJETIVO: El propósito de este estudio fue analizar las posibles influencias del tipo de piso usado en el fútbol de salón y las respuestas adaptativas musculares en practicantes de fútbol de salón masculino. MÉTODOS: La muestra se compuso de 10 jugadores de fútbol de salón, de 20 a 30 años de edad. Mediante la electromiografía de superficie, se realizó la captación de la actividad eléctrica, utilizándose el promedio de la raiz cuadrada de la mediana (RMS) en µV y la fuerza de los principales grupos musculares del miembro inferior dominantes, en reposo, después de dos partidos de fútbol de salón, en dos tipos de pisos de canchas. RESULTADOS: Los hallazgos de este estudio, que involucraron a los parámetros biomecánicos utilizados, mostraron no haber diferencia significativa entre la práctica de fútbol de salón en la cancha con piso de madera y con el sintético, con tendencia de aumento de la actividad eléctrica de la musculatura anterior en la cancha con piso de madera y después ...