The Double Dividend of International Cooperation for Climate Mitigation Cost Effectiveness and Public Health Cobenefits.

Current National Determined Contributions require strengthening to achieve the 2-degree target set in the Paris Agreement. Here, we contrast two mitigation effort strengthening ideas: the "burden-sharing" principle, which requires each region to meet the mitigation goal through domestic mitigation with no international cooperation, and the cooperation focused "cost effective conditional-enhancing" principle, which combines domestic mitigation with carbon trading and low-carbon investment transfer. By applying a burden-sharing model covering several equity principles, we analyze the 2030 mitigation burden for each region, then the energy system model generates the results for the carbon trade and the investment transfer for the conditional-enhancing plan, and an air pollution cobenefit model is used to analyze the cobenefit on air quality and public health. Here, we show that the conditional-enhancing plan leads to an international carbon trading volume of 339.2 billion USD per year and reduces the marginal mitigation cost of the quota-purchase regions by 25%-32%. Furthermore, the international cooperation incentivizes a faster and deeper decarbonization in developing and emerging regions, raising the air pollution health cobenefits by 18% to 731,000 avoided premature deaths annually compared to the "burden-sharing" principle, amounting to a reduction in the life value loss of 131 billion dollars per year.

Financing needs to achieve Nationally Determined Contributions under the Paris Agreement in Caribbean Small Island Developing States.

Caribbean Small Island Developing States (SIDS) are highly vulnerable to the impacts of climate change. Given high mitigation and adaptation costs and constrained domestic finances, they seek international funding to meet their climate objectives. This paper investigates Caribbean SIDS perspectives on the role of international climate finance in addressing climate change and its effectiveness in meeting climate goals. The paper first explored the climate financing needs of sixteen Caribbean SIDS through a content analysis of their Nationally Determined Contributions (NDCs). It then compares the climate finance needs of the region with international climate finance commitments received by examining climate finance trends using data from the Organization for Economic Cooperation and Development (OECD) Development Assistance Committee's (DAC) Creditor Reporting System (CRS). The study revealed large gaps in estimating the climate finance needs of the region, as well as important patterns in the way climate finance is being distributed across mitigation, adaptation and overlap activity; principal versus significant climate objective; recipient country; sector; and source and type of funding. These findings are useful to help countries make decisions about how international climate finance should be used, and how its impacts should be evaluated and a basis for climate finance negotiations and dialogue with bilateral development partners and multilateral climate funds, and to assess whether available funds are being put to good use and identify problems that need to be addressed.

Credibility dilemmas under the Paris agreement: explaining fossil fuel subsidy reform references in INDCs.

Fossil fuel subsidies are a market distortion commonly identified as an obstacle to decarbonization. Yet  due to trenchant political economic risks, reform attempts can be fraught for governments. Despite these concerns, an institutionally and economically diverse group of states included references to fossil fuel subsidy reform (FFSR) in their Intended Nationally Determined Contributions (INDCs) under the Paris Agreement. What conditions might explain why some states reference politically risky reforms within treaty commitments, while most others would not? We argue that the Article 4 process under the Paris Agreement creates a "credibility dilemma" for states-articulating ambitious emissions reduction targets while also defining national climate plans engenders a need to seek out appropriate policy ideas that can justify overarching goals to international audiences. Insomuch as particular norms are institutionalized and made salient in international politics, a window of opportunity is opened: issue advocates can "activate" norms by demonstrating how related policies can make commitments credible. Using mixed methods, we find support for this argument. We identify contextual factors advancing FFSR in the lead-up to the Paris Agreement, including norm institutionalization in regimes and international organization programs as well as salience-boosting climate diplomacy. Further, we find correspondences between countries targeted by transnational policy advocates and FFSR references in INDCs, building on the momentum in international politics more generally. Though drafting INDCs and NDCs is a government-owned process, the results suggest that understanding their content requires examining international norms alongside domestic circumstances.

Indigenous Peoples' rights in national climate governance: An analysis of Nationally Determined Contributions (NDCs).

Although the recognition of Indigenous Peoples' contributions to climate governance by the international community has gradually increased, a rights-based approach in national climate action is still largely absent. This article analyses the recognition of Indigenous Peoples' rights in Nationally Determined Contributions (NDCs) under the Paris Agreement. We conducted a content analysis of all NDCs submitted between 2016 and May 2022. Through a five-pronged framework of sustainable self-determination, we assessed how the NDCs recognise: i. Indigenous Peoples as rights-holders; ii. Indigenous jurisdiction over land; iii. Indigenous knowledge systems; iv. Indigenous Peoples' right to full and effective participation in climate governance; and v. the legacy of colonialism. NDCs with references related to Indigenous Peoples are increasing. However, questions remain regarding their sincerity and commitment to implementation. States must therefore make more significant efforts to ensure that the NDCs take a rights-based approach and contribute to strengthening Indigenous Peoples' role and say in climate governance.

Identifying Emissions Reduction Opportunities in International Bilateral Emissions Trading Systems to Achieve China's Energy Sector NDCs.

Exploring more emissions reduction opportunities for China's energy sector and lowering China's decarbonisation costs are essential to fulfilling China's nationally determined contributions (NDCs) and making China's sustainable development more feasible. This study explored emissions reduction opportunities for China's energy sector in international bilateral emissions trading systems (ETSs) using a CGE (computable general equilibrium) model. This study revealed that linking China's ETS to those of regions with lower decarbonisation responsibilities, which tend to be developing regions, could lower China's carbon prices, thus increasing China's domestic energy supply and lowering energy prices (and vice versa). Meanwhile, the volume of emissions from regions linked to China also significantly affected the degree of the change in China's carbon prices. Among these, ETS links to India and Russia could reduce China's carbon price from 7.80 USD/ton under domestic ETS to 2.16 USD/ton and 6.79 USD/ton, allowing the energy sector and energy-intensive sectors to increase greenhouse gas emissions by 1.14% and 7.05%, respectively, without falling short of meeting its NDC targets. In contrast, as a consequence of links with the United States and the European Union, China's carbon price could increase to 5.37 USD/ton and 1.79 USD/ton, respectively, which would limit China's energy and energy-intensive sectors to emitting 5.45% and 2.24% fewer greenhouse gases in order to meet its NDC targets.

Integrating blue: How do we make nationally determined contributions work for both blue carbon and local coastal communities?

Blue Carbon Ecosystems (BCEs) help mitigate and adapt to climate change but their integration into policy, such as Nationally Determined Contributions (NDCs), remains underdeveloped. Most BCE conservation requires community engagement, hence community-scale projects must be nested within the implementation of NDCs without compromising livelihoods or social justice. Thirty-three experts, drawn from academia, project development and policy, each developed ten key questions for consideration on how to achieve this. These questions were distilled into ten themes, ranked in order of importance, giving three broad categories of people, policy & finance, and science & technology. Critical considerations for success include the need for genuine participation by communities, inclusive project governance, integration of local work into national policies and practices, sustaining livelihoods and income (for example through the voluntary carbon market and/or national Payment for Ecosystem Services and other types of financial compensation schemes) and simplification of carbon accounting and verification methodologies to lower barriers to entry.

Individualism and nationally determined contributions to climate change.

Ratcheting up the Nationally Determined Contributions (NDCs) to achieve the Paris Agreement goals requires a better understanding of the enablers and barriers behind NDC formulation. However, existing quantitative analyses on the drivers of NDCs from an anthropological perspective are elusive. This study proposes both a conceptual framework and empirical analysis of how cultural values link with the pledged NDCs. The findings show that individualism (IDV) is a significant and robust predictor for the mitigation levels of NDCs, after controlling for affluence level, renewable energy proportion, democracy and other socioeconomic factors. For every 10-point increase in the IDV score (say from the score of Canada to Australia or from the score of Vietnam to Mexico), the committed per-capita emission in 2030 relative to 1990 levels decrease by 14%-22%. However, such a correlation is absent when assessing the mitigation ambitions using various fair benchmarks. This study underscores the necessity of considering more cultural context and nuances in tackling common climate problems, and advocates for developing tailored climate communication strategies to enhance the NDCs.

Equitable mitigation to achieve the 1.5 °C goal in the Mediterranean Basin.

The mitigation required to achieve the 1.5 °C goal of the Paris Agreement entails drastic emissions reductions. The mentioned goal is of special interest for regions like the Mediterranean where the average temperature is rising above the world average with the consequential risk for the future viability of its different ecosystems. The objective of this work is to analyze if the commitments of the Mediterranean Basin countries submitted under the Paris Agreement framework are in line with the 1.5 °C goal. For this analysis, the cumulative emissions of the current Nationally Determined Contributions of these countries until 2030, are compared with the result obtained from distributing the cumulative greenhouse gas emissions compatible with the 1.5 °C global mitigation scenario between 2018 and 2100. This distribution is obtained using the Model of Climate Justice that allocates the global emissions by using equity criteria (equality and responsibility) that take into consideration the historical responsibility for each country, in the period from 1994 to 2017. There are two main conclusions from the analysis of the NDCs. Firstly, it is concluded that the Mediterranean Basin countries, as a whole, are not in line with the 1.5 °C goal, because by 2030, 77% of the emissions budget that should be available until 2100, based on the equity criteria aforementioned, will already have been emitted. And, secondly, when the NDCs for each one of the countries are compared, some significant differences in the degree of ambition can be seen.

Nanobodies as efficient drug-carriers: Progress and trends in chemotherapy.

Nanobodies (Nb) have a promising future as a part of next generation chemodrug delivery systems. Nb, or VHH, are small (15 kDa) monomeric antibody fragments consisting of the antigen binding region of heavy chain antibodies. Heavy chain antibodies are naturally produced by camelids, however the structure of their VHH regions can be readily reproduced in industrial expression systems, such as bacteria or yeast. Due to their small size, high solubility, remarkable stability, manipulatable characteristics, excellent in vivo tissue penetration, conjugation advantages, and ease of production, Nb have many advantages when compared against their antibody precursors. In this review, we discuss the generation and selection of Nbs via phage display libraries for easy screening, and the conjugation techniques involved in creating target-specific nanocarriers. Furthermore, we provide a comprehensive overview of recent developments and perspectives in the field of Nb drug conjugates (NDCs) and Nb-based drug vehicles (NDv) with respect to antitumor therapeutics.

Optimizing emissions and carbon credit from integrated solid waste and wastewater management: A MATLAB-based model with a Graphical User Interface (v1).

A new Solid Waste and Wastewater (SWW) management software is presented for optimizing the life-cycle of emissions with carbon credit cost considerations. The software is the first to combine integrated solid waste and wastewater management systems under a single framework when introducing a food waste disposer (FWD) policy. The model/software offers a platform encompassing several tools for life cycle emissions accounting, optimization, as well as economic, policy, and sensitivity analysis. It provides the flexibility of selecting processes or modifying input parameters, as well as disaggregating emissions depending on the scope of accounting. The graphical user interface is applicable in the context of developed and developing economies with the ultimate objective to assist decision makers to allocate expenditures for emissions mitigation measures.