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1.
Nano Lett ; 2024 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-39038223

RESUMO

This study delves into the intriguing properties of the 1H/1T-TaS2 van der Waals heterostructure, focusing on the transparency of the 1H layer to the charge density wave of the underlying 1T layer. Despite the sizable interlayer separation and metallic nature of the 1H layer, positive bias voltages result in a pronounced superposition of the 1T charge density wave structure on the 1H layer. The conventional explanation relying on tunneling effects proves insufficient. Through a comprehensive investigation combining low-temperature scanning tunneling microscopy, scanning tunneling spectroscopy, non-contact atomic force microscopy, and first-principles calculations, we propose an alternative interpretation. The transparency effect arises from a weak yet substantial electronic coupling between the 1H and 1T layers, challenging prior understanding of the system. Our results highlight the critical role played by interlayer electronic interactions in van der Waals heterostructures to determine the final ground states of the systems.

2.
Arch Sex Behav ; 53(1): 43-56, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37749338

RESUMO

This study sought to examine neuropsychological functioning in men with pedophilic disorder (PD), in order to assess whether findings from prior neuropsychological studies are replicated in a diverse sample including men with non-contact sexual offenses. It was hypothesized that when non-contact offenders are included in the study, a slowed processing speed will emerge as the only finding unique to men with PD. A comprehensive neuropsychological battery was administered to 58 men convicted of a sexual offense, 20 of whom were classified as having PD. The sample included men with contact sexual offenses (n = 33), non-contact sexual offenses (n = 5), and child sexual abuse material (CSAM) offenses (n = 20). Test performance was compared by PD status. Participants with PD performed significantly better on verbal memory and visual discrimination than those without PD. Men with PD made more errors on a set-shifting task but no significant differences were seen in domains of attention, intellectual functioning, visual learning and memory, visuospatial ability, or language ability. Effect sizes were generally small, although some medium effects were seen (visual discrimination and verbal learning and memory). Scores in both groups (with and without PD) were generally in the average range across tasks. Within the subgroup of CSAM offenders, minimal differences emerged between those with and without PD, although those with PD were slower on visuomotor set-shifting but made fewer errors (d = - 0.89). CSAM offenders with PD were in the high average range on many tasks of intellectual functioning; however, a potential trend was identified such that CSAM offenders without PD had lower scores on a task of verbal learning and memory, with medium effect sizes observed. As few differences in neuropsychological functioning emerged when comparing offenders with and without PD, differences demonstrated in prior research may be better attributed to contact offending status rather than sexual interest.


Assuntos
Abuso Sexual na Infância , Criminosos , Pedofilia , Delitos Sexuais , Masculino , Humanos , Criança , Pedofilia/psicologia , Literatura Erótica/psicologia , Abuso Sexual na Infância/psicologia , Cognição
3.
BMC Musculoskelet Disord ; 25(1): 448, 2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38844912

RESUMO

INTRODUCTION: Fractures of the scaphoid are the most common carpal injuries, account for 80-90% of all carpal fractures. 5-15% nonunion of scaphoid fractures were reported even with adequate primary treatment, which probably progresses to osteoarthritic changes several decades later. Researches regarding to scaphoid physiological characteristic in vitro and in vivo and kinds of trials in clinical practice are being kept on going, which contribute much to our clinical practice. With the advancing wrist arthroscopy, 3D-print patient-specific drill guide, and intraoperative fluoroscopic guidance, dorsal approach (mini-invasive and percutaneous technique) is being popular, through which we can implant the screw in good coincidence with biomechanics and with less disturbing tenuous blood supply of the scaphoid. Investigating the noncontact area of the dorsal proximal scaphoid in different wrist positions can facilitate preoperatively estimating insert point of the screw. MATERIALS AND METHODS: Eight volunteers were recruited to accept CT scans in six extreme wrist positions. The images of DICOM mode were imput into the Mimics analytical system, the segmented scaphoid, lunate and radius were exported in mode of ASCII STL and were opened in the software of Geomagic studio. We created four planes based on anatomic markers on the surface of the radius and scaphoid to confine the proximal scaphoid to form the so-called non-contact regions. We measured and compared the areas in six targeted positions. RESULTS: Amidst six extreme wrist positions, area of the non-contact region in extreme dorsal extension (59.81 ± 26.46 mm2) was significantly the smallest, and it in extreme palmar flexion significantly was largest (170.51 ± 30.44 mm2). The non-contact regions increased in order of dorsal extension, supination, ulnar deviation, radial deviation, pronation and palmar flexion. As for two-group comparison, the non-contact region showed significantly larger (p < 0.05) in palmar flexion than the others except for in pronation individually, and in radial deviation (p < 0.05) than in dorsal extension. CONCLUSIONS: Sufficient space was available for the screw started from the dorsal approach despite the wrist positions.


Assuntos
Osso Escafoide , Articulação do Punho , Humanos , Osso Escafoide/cirurgia , Osso Escafoide/lesões , Osso Escafoide/diagnóstico por imagem , Masculino , Adulto , Articulação do Punho/cirurgia , Articulação do Punho/diagnóstico por imagem , Feminino , Tomografia Computadorizada por Raios X , Parafusos Ósseos , Adulto Jovem , Amplitude de Movimento Articular , Pronação/fisiologia , Fenômenos Biomecânicos
4.
Sensors (Basel) ; 24(7)2024 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-38610269

RESUMO

An increasing number of studies on non-contact vital sign detection using radar are now beginning to turn to data-driven neural network approaches rather than traditional signal-processing methods. However, there are few radar datasets available for deep learning due to the difficulty of acquiring and labeling the data, which require specialized equipment and physician collaboration. This paper presents a new model of heartbeat-induced chest wall motion (CWM) with the goal of generating a large amount of simulation data to support deep learning methods. An in-depth analysis of published CWM data collected by the VICON Infrared (IR) motion capture system and continuous wave (CW) radar system during respiratory hold was used to summarize the motion characteristics of each stage within a cardiac cycle. In combination with the physiological properties of the heartbeat, appropriate mathematical functions were selected to describe these movement properties. The model produced simulation data that closely matched the measured data as evaluated by dynamic time warping (DTW) and the root-mean-squared error (RMSE). By adjusting the model parameters, the heartbeat signals of different individuals were simulated. This will accelerate the application of data-driven deep learning methods in radar-based non-contact vital sign detection research and further advance the field.


Assuntos
Parede Torácica , Humanos , Radar , Movimento (Física) , Movimento , Simulação por Computador
5.
Sensors (Basel) ; 24(2)2024 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-38257481

RESUMO

This paper proposes a non-contact current measurement method for three-phase rectangular busbars based on TMR (tunneling magneto-resistance) sensors, due to their advantages of large dynamic range, wide bandwidth, light weight, and easy installation. A non-contact current sensor composed of only three TMR sensors is developed and the TMR sensors are respectively placed at a location with a certain distance from the surface of each rectangular busbar to measure the magnetic fields generated by the busbar currents. To calibrate the developed current sensor, i.e., to establish the relationship between the magnetic fields measured by the TMR sensors and the currents flowing in the three-phase rectangular busbars, we designed a thyristor-controlled resistive load as a calibrator, which is connected to a downstream branch of the distribution cabinet. By switching the resistive load, a calibration current, which can be identified from the background current, is generated in one rectangular busbar and its value is measured at the location of the calibrator, and transmitted wirelessly to the location of the TMR sensors. A new and robust method is proposed to extract the voltage components, corresponding to the calibration current, from the voltage waveforms of the TMR sensors. By calculating the proportional coefficients between the calibration currents and the extracted voltage components, online calibration of the current sensor is achieved. We designed and implemented a current measurement system consisting of a current sensor using TMR sensors, a thyristor-controlled resistive load for current sensor calibration, and a data acquisition circuit based on a multi-channel analog-to-digital converter (ADC). Current measurement experiments were performed in a practical distribution cabinet installed in our laboratory. Compared to the measurement results using a commercial current probe with an accuracy of 1%, the relative error of the measured currents in RMS is less than 2.5% and the phase error is less than 1°, while the nonlinearity error of the current sensor is better than 0.8%.

6.
Sensors (Basel) ; 24(12)2024 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-38931747

RESUMO

The development of non-contact techniques for monitoring human vital signs has significant potential to improve patient care in diverse settings. By facilitating easier and more convenient monitoring, these techniques can prevent serious health issues and improve patient outcomes, especially for those unable or unwilling to travel to traditional healthcare environments. This systematic review examines recent advancements in non-contact vital sign monitoring techniques, evaluating publicly available datasets and signal preprocessing methods. Additionally, we identified potential future research directions in this rapidly evolving field.


Assuntos
Sinais Vitais , Humanos , Sinais Vitais/fisiologia , Monitorização Fisiológica/métodos , Processamento de Sinais Assistido por Computador
7.
Sensors (Basel) ; 24(8)2024 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-38676027

RESUMO

The variety of equipment implementing laser triangulation technology for 3D scanning makes it difficult to analyse their performance, comparability, and traceability. In this study, three laser triangulation sensors arranged in different configurations are analysed using high precision spheres made of different materials and surface finishes. Three types of reference parameters were used: diameter, form error, and standard deviation of the point cloud. The experimentation was based on studying the quality of the point clouds generated by the three sensors, which enabled us to find and quantify an edge effect in the horizon of the scanned surface. A procedure to reach the optimal filtering conditions was proposed, and a chart of recommended usage of each sphere (material and finish) was created for the different types of sensors. This filter enables removal of both spurious points and those few points that spoil the form error, greatly improving the quality of the measurement.

8.
Sensors (Basel) ; 24(7)2024 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-38610322

RESUMO

This paper introduces an innovative non-contact heart rate monitoring method based on Wi-Fi Channel State Information (CSI). This approach integrates both amplitude and phase information of the CSI signal through rotational projection, aiming to optimize the accuracy of heart rate estimation in home environments. We develop a frequency domain subcarrier selection algorithm based on Heartbeat to subcomponent ratio (HSR) and design a complete set of signal filtering and subcarrier selection processes to further enhance the accuracy of heart rate estimation. Heart rate estimation is conducted by combining the peak frequencies of multiple subcarriers. Extensive experimental validations demonstrate that our method exhibits exceptional performance under various environmental conditions. The experimental results show that our subcarrier selection method for heart rate estimation achieves an average accuracy of 96.8%, with a median error of only 0.8 bpm, representing an approximately 20% performance improvement over existing technologies.

9.
Sensors (Basel) ; 24(11)2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38894090

RESUMO

This paper presents an overview of integrating new research outcomes into the development of a structural health monitoring strategy for the floating cover at the Western Treatment Plant (WTP) in Melbourne, Australia. The size of this floating cover, which covers an area of approximately 470 m × 200 m, combined with the hazardous environment and its exposure to extreme weather conditions, only allows for monitoring techniques based on remote sensing. The floating cover is deformed by the accumulation of sewage matter beneath it. Our research has shown that the only reliable data for constructing a predictive model to support the structural health monitoring of this critical asset is obtained directly from the actual floating cover at the sewage treatment plant. Our recent research outcomes lead us towards conceptualising an advanced engineering analysis tool designed to support the future creation of a digital twin for the floating cover at the WTP. Foundational work demonstrates the effectiveness of an unmanned aerial vehicle (UAV)-based photogrammetry methodology in generating a digital elevation model of the large floating cover. A substantial set of data has been acquired through regular UAV flights, presenting opportunities to leverage this information for a deeper understanding of the interactions between operational conditions and the structural response of the floating cover. This paper discusses the current findings and their implications, clarifying how these outcomes contribute to the ongoing development of an advanced digital twin for the floating cover.

10.
Sensors (Basel) ; 24(11)2024 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-38894333

RESUMO

In recent years, hypertension has become one of the leading causes of illness and death worldwide. Changes in lifestyle among the population have led to an increasing prevalence of hypertension. This study proposes a non-contact blood pressure estimation method that allows patients to conveniently monitor their blood pressure values. By utilizing a webcam to track facial features and the region of interest (ROI) for obtaining forehead images, independent component analysis (ICA) is employed to eliminate artifact signals. Subsequently, physiological parameters are calculated using the principle of optical wave reflection. The Nelder-Mead (NM) simplex method is combined with the particle swarm optimization (PSO) algorithm to optimize the empirical parameters, thus enhancing computational efficiency and accurately determining the optimal solution for blood pressure estimation. The influences of light intensity and camera distance on the experimental results are also discussed. Furthermore, the measurement time is only 10 s. The superior accuracy and efficiency of the proposed methodology are demonstrated by comparing them with those in other published literature.


Assuntos
Algoritmos , Determinação da Pressão Arterial , Pressão Sanguínea , Humanos , Pressão Sanguínea/fisiologia , Determinação da Pressão Arterial/métodos , Hipertensão/fisiopatologia , Hipertensão/diagnóstico , Processamento de Sinais Assistido por Computador
11.
Sensors (Basel) ; 24(5)2024 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-38474915

RESUMO

This work investigates a new sensing technology for use in robotic human-machine interface (HMI) applications. The proposed method uses near E-field sensing to measure small changes in the limb surface topography due to muscle actuation over time. The sensors introduced in this work provide a non-contact, low-computational-cost, and low-noise method for sensing muscle activity. By evaluating the key sensor characteristics, such as accuracy, hysteresis, and resolution, the performance of this sensor is validated. Then, to understand the potential performance in intention detection, the unmodified digital output of the sensor is analysed against movements of the hand and fingers. This is done to demonstrate the worst-case scenario and to show that the sensor provides highly targeted and relevant data on muscle activation before any further processing. Finally, a convolutional neural network is used to perform joint angle prediction over nine degrees of freedom, achieving high-level regression performance with an RMSE value of less than six degrees for thumb and wrist movements and 11 degrees for finger movements. This work demonstrates the promising performance of this novel approach to sensing for use in human-machine interfaces.


Assuntos
Procedimentos Cirúrgicos Robóticos , Humanos , Mãos/fisiologia , Dedos/fisiologia , Punho/fisiologia , Polegar
12.
J Clin Monit Comput ; 38(1): 77-88, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37792139

RESUMO

PURPOSE: Non-contact continuous respiratory rate monitoring is preferred for early detection of patient deterioration. However, this technique is under development; a gold standard respiratory monitor has not been established. Therefore, this prospective observational method comparison study aimed to compare the measurement accuracy of a non-contact continuous respiratory rate monitor, a microwave Doppler sensor positioned beneath the mattress, with that of other monitors. METHODS: The respiratory rate of intensive care unit patients was simultaneously measured using a microwave Doppler sensor, capnography, thoracic impedance pneumography, and a piezoelectric sensor beneath the mattress. Bias and 95% limits of agreement between the respiratory rate measured using capnography (standard reference) and that measured using the other three methods were calculated using Bland-Altman analysis for repeated measures. Clarke error grid (CEG) analysis evaluated the sensor's ability to assist in correct clinical decision-making. RESULTS: Eighteen participants were included, and 2,307 data points were analyzed. The bias values (95% limits of agreement) of the microwave Doppler sensor, thoracic impedance pneumography, and piezoelectric sensor were 0.2 (- 4.8 to 5.2), 1.5 (- 4.4 to 7.4), and 0.4 (- 4.0 to 4.8) breaths per minute, respectively. Clinical decisions evaluated using CEG analyses were correct 98.1% of the time for the microwave Doppler sensor, which was similar to the performance of the other devices. CONCLUSION: The microwave Doppler sensor had a small bias but relatively low precision, similar to other devices. In CEG analyses, the risk of each monitor leading to inadequate clinical decision-making was low. TRIAL REGISTRATION NUMBER: UMIN000038900, February 1, 2020.


Assuntos
Micro-Ondas , Taxa Respiratória , Humanos , Reprodutibilidade dos Testes , Monitorização Fisiológica/métodos , Capnografia/métodos
13.
J Pediatr Nurs ; 77: e616-e624, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38824078

RESUMO

BACKGROUND: This study was conducted to compare the accuracy of two noninvasive thermometers (axillary and infrared non-contact forehead thermometer) in measuring core temperature compared to the gold standard oral thermometer in the detection of fever in pediatric cancer patients with febrile neutropenia. METHODS: The study was conducted with a single group of 42 children with febrile neutropenia between 23 December 2020 and 25 January 2023 in the pediatric hematology and oncology clinic of a training and research hospital, which provides a specialized environment for both medical education and advanced scientific research in the field of pediatric hematology and oncology. The participants' body temperature was measured with an oral, axillary, and non-contact infrared forehead thermometer immediately after admission to the clinic and at 5 and 10 min after admission. The inter-rater agreement for each method and inter-method agreement between axillary and non-contact infrared temperature readings and oral readings were analyzed for each time point using intraclass correlation coefficients (ICC). RESULTS: The children in the study had a mean age of 11.62 ± 3.00 years and 28 (66.7%) were boys, 19 (45.2%) were younger children (5-10 years of age), and 23 (54.8%) were adolescents (11-16 years of age). In the analysis of agreement between the thermometers at admission and at 5 and 10 min after admission in children with febrile neutropenia, the highest agreement was between the oral and axillary thermometers (ICC: 0.584, 0.835, 0.536, respectively) and the lowest agreement was between the oral and non-contact infrared thermometers (ICC: 0.219, 0.022, 0.473, respectively). CONCLUSION: Compared to orally measured body temperature, axillary temperature readings showed better agreement than non-contact infrared temperature readings from the forehead in pediatric patients with febrile neutropenia. PRACTICE IMPLICATIONS: The research findings may guide nurses and families caring for pediatric patients with febrile neutropenia and should contribute to the prevention of false findings of fever and the reduction of its adverse consequences.


Assuntos
Temperatura Corporal , Neutropenia Febril , Neoplasias , Termômetros , Humanos , Criança , Masculino , Feminino , Adolescente , Neutropenia Febril/diagnóstico , Neoplasias/complicações , Temperatura Corporal/fisiologia , Pré-Escolar , Axila , Febre/diagnóstico
14.
Molecules ; 29(10)2024 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-38792232

RESUMO

Poly(2-hydroxyethylmethacrylate-co-2-(dimethylamino)ethyl methacrylate), P(HEMA-co-DMAEMAx), copolymers were quaternized through the reaction of a part of (dimethylamino)ethyl moieties of DMAEMA units with 1-bromohexadecane. Antimicrobial coatings were further prepared through the cross-linking reaction between the remaining DMAEMA units of these copolymers and the epoxide ring of poly(N,N-dimethylacrylamide-co-glycidyl methacrylate), P(DMAm-co-GMAx), copolymers. The combination of P(HEMA-co-DMAEMAx)/P(DMAm-co-GMAx) copolymers not only enabled control over quaternization and cross-linking for coating stabilization but also allowed the optimization of the processing routes towards a more facile cost-effective methodology and the use of environmentally friendly solvents like ethanol. Careful consideration was given to achieve the right content of quaternized units, qDMAEMA, to ensure antimicrobial efficacy through an appropriate amphiphilic balance and sufficient free DMAEMA groups to react with GMA for coating stabilization. Optimal synthesis conditions were achieved by membranes consisting of cross-linked P(HEMA78-co-DMAEMA9-co-qDMAEMA13)/P(DMAm-co-GMA42) membranes. The obtained membranes were multifunctional as they were self-standing and antimicrobial, while they demonstrated a distinct fast response to changes in humidity levels, widening the opportunities for the construction of "smart" antimicrobial actuators, such as non-contact antimicrobial switches.


Assuntos
Anti-Infecciosos , Umidade , Metacrilatos , Metacrilatos/química , Anti-Infecciosos/farmacologia , Anti-Infecciosos/química , Anti-Infecciosos/síntese química , Reagentes de Ligações Cruzadas/química , Testes de Sensibilidade Microbiana , Polímeros/química , Polímeros/síntese química , Polímeros/farmacologia
15.
Sex Abuse ; 36(3): 320-348, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37019092

RESUMO

Over the last 50 years, there has been a plethora of research exploring sexual offending with a recent focus on online offending. However, little research has focused on voyeurism despite convictions and media awareness growing rapidly. Currently, there is sparse theoretical or empirical literature to guide research and practice for individuals engaging in voyeuristic behaviors. As such, 17 incarcerated men with a conviction of voyeurism in the UK were interviewed on the cognitive, affective, behavioral, and contextual factors leading up to and surrounding their offense(s). Grounded theory analyses were used to develop a temporal model from background factors to post-offense factors; the Descriptive Model of Voyeuristic Behavior (DMV). The model highlights vulnerability factors for men engaging in voyeuristic behaviors in this sample. Following this, the same 17 men were plotted through the model and three key pathways were identified: Sexual Gratification, Maladaptive Connection Seeking, and Access to Inappropriate Person(s). The characteristics of each pathway are discussed, and treatment implications considered.


Assuntos
Delitos Sexuais , Voyeurismo , Masculino , Humanos , Voyeurismo/psicologia , Comportamento Sexual/psicologia , Fatores de Risco , Delitos Sexuais/psicologia
16.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 41(3): 461-468, 2024 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-38932531

RESUMO

To achieve non-contact measurement of human heart rate and improve its accuracy, this paper proposes a method for measuring human heart rate based on multi-channel radar data fusion. The radar data were firstly extracted by human body position identification, phase extraction and unwinding, phase difference, band-pass filtering optimized by power spectrum entropy, and fast independent component analysis for each channel data. After overlaying and fusing the four-channel data, the heartbeat signal was separated using frost-optimized variational modal decomposition. Finally, a chirp Z-transform was introduced for heart rate estimation. After validation with 40 sets of data, the average root mean square error of the proposed method was 2.35 beats per minute, with an average error rate of 2.39%, a Pearson correlation coefficient of 0.97, a confidence interval of [-4.78, 4.78] beats per minute, and a consistency error of -0.04. The experimental results show that the proposed measurement method performs well in terms of accuracy, correlation, and consistency, enabling precise measurement of human heart rate.


Assuntos
Algoritmos , Frequência Cardíaca , Radar , Processamento de Sinais Assistido por Computador , Humanos , Frequência Cardíaca/fisiologia
17.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 41(2): 272-280, 2024 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-38686407

RESUMO

The existing one-time identity authentication technology cannot continuously guarantee the legitimacy of user identity during the whole human-computer interaction session, and often requires active cooperation of users, which seriously limits the availability. This study proposes a new non-contact identity recognition technology based on cardiac micro-motion detection using ultra wideband (UWB) bio-radar. After the multi-point micro-motion echoes in the range dimension of the human heart surface area were continuously detected by ultra wideband bio-radar, the two-dimensional principal component analysis (2D-PCA) was exploited to extract the compressed features of the two-dimensional image matrix, namely the distance channel-heart beat sampling point (DC-HBP) matrix, in each accurate segmented heart beat cycle for identity recognition. In the practical measurement experiment, based on the proposed multi-range-bin & 2D-PCA feature scheme along with two conventional reference feature schemes, three typical classifiers were selected as representatives to conduct the heart beat identification under two states of normal breathing and breath holding. The results showed that the multi-range-bin & 2D-PCA feature scheme proposed in this paper showed the best recognition effect. Compared with the optimal range-bin & overall heart beat feature scheme, our proposed scheme held an overall average recognition accuracy of 6.16% higher (normal respiration: 6.84%; breath holding: 5.48%). Compared with the multi-distance unit & whole heart beat feature scheme, the overall average accuracy increase was 27.42% (normal respiration: 28.63%; breath holding: 26.21%) for our proposed scheme. This study is expected to provide a new method of undisturbed, all-weather, non-contact and continuous identification for authentication.


Assuntos
Coração , Análise de Componente Principal , Humanos , Coração/fisiologia , Algoritmos , Frequência Cardíaca , Processamento de Sinais Assistido por Computador , Movimento (Física) , Identificação Biométrica/métodos , Respiração
18.
Cytokine ; 161: 156058, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36209650

RESUMO

Understanding the crosstalk between endothelial cells (ECs) and bone-marrow mesenchymal stem cells (BMSCs) in response to hypoxic environments and deciphering of the underlying mechanisms are of great relevance for better application of BMSCs in tissue engineering. Here, we demonstrated that hypoxia promoted BMSCs proliferation, colony formation, osteogenic markers expression, mineralization, and extracellular signal-regulated protein kinase (ERK) phosphorylation, and that PD98059 (ERK inhibitor) blocked hypoxia-induced osteogenic differentiation. Hypoxia enhanced ECs migration, cyclooxygenase 2 (COX-2) and integrin αvß3 expression, and prostaglandin E2 (PGE2), vascular endothelial growth factor (VEGF) secretion. NS398 (selective COX-2 inhibitor) and LM609 (integrin αvß3 specific inhibitor) impaired the ECs response to hypoxia, and exogenous PGE2 partially reversed the effects of NS398. BMSCs: ECs co-culture under hypoxia upregulated BMSCs osteogenesis and ERK phosphorylation, as well as ECs migration, integrin αvß3 expression, and PGE2 and VEGF secretion. NS398 (pretreated ECs) lessened PGE2, VEGF concentrations of the co-culture system. NS398-treated ECs and AH6809 (combined EP1/2 antagonist)/L-798106 (selective EP3 antagonist)/L-161982 (selective EP4 antagonist)/SU5416 [VEGF receptor (VEGFR) inhibitor]-treated BMSCs impaired the co-cultured ECs-induced enhancement of BMSCs osteogenic differentiation. In conclusion, hypoxia enhances BMSCs proliferation and ERK-mediated osteogenic differentiation, and augments the COX-2-dependent PGE2 and VEGF release, integrin αvß3 expression, and migration of ECs. COX-2/PGE2/VEGF signaling is involved in intercellular BMSCs: ECs communication under hypoxia.


Assuntos
Células-Tronco Mesenquimais , Osteogênese , Diferenciação Celular , Células Cultivadas , Ciclo-Oxigenase 2/metabolismo , Dinoprostona/metabolismo , Células Endoteliais/metabolismo , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Hipóxia/metabolismo , Integrinas , Células-Tronco Mesenquimais/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismo
19.
BMC Med Inform Decis Mak ; 23(1): 179, 2023 09 11.
Artigo em Inglês | MEDLINE | ID: mdl-37697312

RESUMO

Addressing the current complexities, costs, and adherence issues in the detection of forward head posture (FHP), our study conducted an exhaustive epidemiologic investigation, incorporating a comprehensive posture screening process for each participant in China. This research introduces an avant-garde, machine learning-based non-contact method for the accurate discernment of FHP. Our approach elevates detection accuracy by leveraging body landmarks identified from human images, followed by the application of a genetic algorithm for precise feature identification and posture estimation. Observational data corroborates the superior efficacy of the Extra Tree Classifier technique in FHP detection, attaining an accuracy of 82.4%, a specificity of 85.5%, and a positive predictive value of 90.2%. Our model affords a rapid, effective solution for FHP identification, spotlighting the transformative potential of the convergence of feature point recognition and genetic algorithms in non-contact posture detection. The expansive potential and paramount importance of these applications in this niche field are therefore underscored.


Assuntos
Pontos de Referência Anatômicos , População do Leste Asiático , Postura , Adolescente , Humanos , Povo Asiático , Aprendizado de Máquina , Postura/fisiologia , Algoritmos
20.
Arch Gynecol Obstet ; 307(1): 187-194, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-35284956

RESUMO

PURPOSE: Endometriosis is a benign, but potentially serious gynaecological condition in terms of abdominal pain and impaired fertility. Laparoscopic excision techniques are considered the therapeutic standard. HybridAPC is presented as a novel technique for the non-contact thermal ablation of peritoneal endometriosis with simultaneous protection of the underlying thermosensitive structures by creating a needle-free elevated fluid cushion which enables a safer exposure and distance, as well as potentially improved peritoneal conditioning prior to APC. METHODS: In this prospective randomized clinical trial, 39 patients with 132 superficial endometriotic lesions in total were treated with HybridAPC or sharp excision in an initial laparoscopic procedure according to randomization. In a second-look laparoscopy, adhesion formation was rated macroscopically. Histologic samples were taken from previously treated areas for evaluation of eradication rate. RESULTS: The eradication rate was not significantly different between HybridAPC treatment and sharp excision (65 vs. 81%, p = .55). Adhesions formed in 5% of HybridAPC-treated lesions and in 10% after sharp excision (p = .49). HybridAPC treatment was significantly faster than sharp excision (69 vs. 106 s, p < .05). No intra- and postoperative complications were registered. CONCLUSION: This clinical trial demonstrates the feasibility of this novel surgical technique with a promising impact on adhesion prevention. Compared to sharp excision, HybridAPC is likely to be a safe, tissue-preserving, and fast method for the treatment of peritoneal endometriosis.


Assuntos
Endometriose , Laparoscopia , Feminino , Humanos , Endometriose/cirurgia , Endometriose/patologia , Coagulação com Plasma de Argônio , Estudos Prospectivos , Peritônio/patologia , Laparoscopia/métodos , Aderências Teciduais/prevenção & controle , Aderências Teciduais/cirurgia , Aderências Teciduais/patologia
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