RESUMO
The thalamus is a key element of sensory transmission in the brain, as it gates and selects sensory streams through a modulation of its internal activity. A preponderant role in these functions is played by its internal activity in the alpha range ([8-14] Hz), but the mechanism underlying this process is not completely understood. In particular, how do thalamocortical connections convey stimulus driven information selectively over the back-ground of thalamic internally generated activity? Here we investigate this issue with a spiking network model of feedforward connectivity between thalamus and primary sensory cortex reproducing the local field potential of both areas. We found that in a feedforward network, thalamic oscillations in the alpha range do not entrain cortical activity for two reasons: (i) alpha range oscillations are weaker in neurons projecting to the cortex, (ii) the gamma resonance dynamics of cortical networks hampers oscillations over the 10-20 Hz range thus weakening alpha range oscillations. This latter mechanism depends on the balance of the strength of thalamocortical connections toward excitatory and inhibitory neurons in the cortex. Our results highlight the relevance of corticothalamic feedback to sustain alpha range oscillations and pave the way toward an integrated understanding of the sensory streams traveling between the periphery and the cortex.
Assuntos
Neurônios , Tálamo , Encéfalo , Córtex Cerebral/fisiologia , Humanos , Neurônios/fisiologia , Tálamo/fisiologiaRESUMO
Mooring systems are an integral and sophisticated component of offshore assets and are subject to harsh conditions and cyclic loading. The early detection and characterisation of fatigue crack growth remain a crucial challenge. The scope of the present work was to establish filtering and alarm criteria for different crack growth stages by evaluating the recorded signals and their features. The analysis and definition of parametrical limits, and the correlation of their characteristics with the crack, helped to identify approaches to discriminate between noise, initiation, and growth-related signals. Based on these, a filtering criterion was established, to support the identification of the different growth stages and noise with the aim to provide early warnings of potential damage.
Assuntos
Fadiga , Humanos , Estresse MecânicoRESUMO
Simulation techniques implemented with the HFSS program were used for structure optimization from the point of view of increasing the conductivity of the batteries' electrolytes. Our analysis was focused on reliable "beyond lithium-ion" batteries, using single-ion conducting polymer electrolytes, in a gel variant. Their conductivity can be increased by tuning and correlating the internal parameters of the structure. Materials in the battery system were modeled at the nanoscale with HFSS: electrodes-electrolyte-moving ions. Some new materials reported in the literature were studied, like poly(ethylene glycol) dimethacrylate-x-styrene sulfonate (PEGDMA-SS) or PU-TFMSI for the electrolyte; p-dopable polytriphenyl amine for cathodes in Na-ion batteries or sulfur cathodes in Mg-ion or Al-ion batteries. The coarse-grained molecular dynamics model combined with the atomistic model were both considered for structural simulation at the molecular level. Issues like interaction forces at the nanoscopic scale, charge carrier mobility, conductivity in the cell, and energy density of the electrodes were implied in the analysis. The results were compared to the reported experimental data, to confirm the method and for error analysis. For the real structures of gel polymer electrolytes, this method can indicate that their conductivity increases up to 15%, and even up to 26% in the resonant cases, via parameter correlation. The tuning and control of material properties becomes a problem of structure optimization, solved with non-invasive simulation methods, in agreement with the experiment.