Prevalence and Risk Factors for Metamorphopsia after Successful Retinal Detachment Surgery.

INTRODUCTION: The aim of the study was to determine the prevalence of metamorphopsia following rhegmatogenous retinal detachment (RRD) surgery, as well as associated predictive factors. METHODS: A total of 107 eyes successfully operated for RRD underwent metamorphopsia severity assessment using M-CHARTS, and foveal microstructure analysis by spectral domain optical coherence tomography, at 1 and 6 months postoperatively. Univariate and multivariate logistic regression rendered evaluation of preoperative risk factors. The correlation between metamorphopsia score and outer retinal layer (ORL) integrity was investigated and preoperative risk factors evaluated. RESULTS: The prevalence of postoperative metamorphopsia decreased from 51.4 to 29.9% and the median metamorphopsia score significantly improved (0.5, 95% CI: 0.3; 0.9, to 0.2, 95% CI: 0; 0.5, p < 0.001) from 1 to 6 months, respectively. Preoperative macular detachment was the only predictor found (OR 11.0, 95% CI: 3.1; 39.4, p < 0.001). Metamorphopsia severity was significantly associated with outer nuclear layer thickness and the status of the ellipsoid and cone interdigitation zones. One-month M-CHARTS had 81% sensitivity and 87% specificity in predicting full metamorphopsia recovery at 6 months (0.45 cut-off score). CONCLUSION: The prevalence of metamorphopsia decreased in parallel to ORL restoration, thus demonstrating the etiological role of photoreceptor-level morphological changes. M-CHARTS allowed for monitoring and predicting metamorphopsia recovery after RRD.

Longitudinal Microvascular Changes on Optical Coherence Tomographic Angiography after Macula-Off Rhegmatogenous Retinal Detachment Repair Surgery.

PURPOSE: To investigate longitudinal changes and associated factors for microvascular parameters in macula-off rhegmatogenous retinal detachment (RRD) after repair surgery. METHODS: This is a retrospective study of 34 eyes with macula-off RRD. The foveal avascular zone (FAZ) area and parafoveal vessel density were recorded every 3 months for 1 year after surgery. We analyzed 3 × 3 mm and 6 × 6 mm swept-source optical coherence tomographic (OCT) angiography images to quantify microvascular parameters. Individual clinical factors and pre- and postoperative OCT images were analyzed to find factors associated with changes in the FAZ area and vessel density 12 months after surgery. RESULTS: The differences in FAZ area and vessel density between the operated and fellow eye at 3, 6, 9, and 12 months postoperatively were 0.127 ± 0.05, 0.111 ± 0.06, 0.108 ± 0.07, and 0.105 ± 0.06 mm2 and 4.33 ± 1.42, 3.56 ± 2.05, 2.73 ± 1.72, and 2.61 ± 1.71/mm. Preoperative sensory retina thickness and surgical methods significantly correlated with decreased vessel density at 12 months. Surgical method-based analysis found that postoperative vessel density damage in the pars plana vitrectomy (PPV) group was more prominent than in the buckling group. CONCLUSION: After macula-off RRD surgery, microvascular parameters were impaired after successful anatomical repair but recovered over 12 months. The PPV group exhibited significantly lower postoperative parafoveal vessel density than the buckling group.

Comparative effect of topical diclofenac and topical dexamethasone on anterior chamber flare and postoperative pain following rhegmatogenous retinal detachment surgery.

The purpose of this study is to compare the effect of topical diclofenac and topical dexamethasone on anterior chamber flare and postoperative pain following rhegmatogenous retinal detachment (RRD) surgery. This prospective study included 40 eyes of 40 patients treated for RRD. Twenty-eight patients underwent scleral buckling and 12 patients underwent 20-gauge pars plana vitrectomy (PPV). For each surgical procedure, patients were postoperatively randomly divided into two groups: the first group received topical dexamethasone phosphate 0.1 % four times daily for 28 days; the second group received topical diclofenac sodium 0.1 % three times daily for 28 days. The inflammatory reaction in the anterior chamber was measured with laser flare photometry preoperatively and 1, 7, 14, 28, and 90 days postoperatively. Pain level was evaluated with Scott's visual analog scale at day 1, 7, 14, and 28 postoperatively. For patients treated with scleral buckling, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p = 0.096), day 7 (p = 0.435), day 14 (p = 0.510), day 28 (p = 0.583), and day 90 (p = 0.423). The group who received diclofenac had significantly lower pain score at days 7, 14, and 28 (p = 0.048, p = 0.017, and p = 0.028, respectively). For patients treated with PPV, there was no significant difference between the two groups regarding mean aqueous flare at day 1 (p = 0.400), day 7 (p = 0.728), day 14 (p = 0.843), day 28 (p = 0.939), and day 90 (p = 0.568). Patients who received diclofenac had significantly lower pain score at days 7, 14, and 28 (p = 0.032, p = 0.030, and p = 0.023, respectively). Topical diclofenac seems to be as potent as topical dexamethasone in managing postoperative inflammatory response induced by surgery for RRD with better analgesic effect. Both of them are consequences of blood-aqueous barrier and blood-retinal barrier breakdown.