Serum sickness-like reaction to D-supplement: a case report.

BACKGROUND: Serum Sickness-Like Reaction (SSLR) is an immune response characterized by rash, polyarthralgias, inflammation, and fever. Serum sickness-like reaction is commonly attributed to antibiotics, anticonvulsants, and anti-inflammatory agents. CASE PRESENTATION: A 16-year-old female with a history of overactive bladder and anemia presented with a diffuse urticarial rash, headaches, joint pain, and swelling for three days. Her medications included oral contraceptive pills, iron, mirabegron, UQora, and a probiotic. Physical examination revealed a diffuse urticarial rash, and her musculoskeletal exam revealed swelling and tenderness in her wrists. She was evaluated by her pediatrician and started on a 7-day course of prednisone, as well as antihistamines. Her CBC, basic metabolic panel, liver function panel, Lyme titers, and urinalysis were all within normal limits. With concern for hypersensitivity reaction to medication, all medications were discontinued. Nine days after symptom onset, the patient was evaluated by an allergist, who confirmed her presentation was consistent with serum sickness-like reaction. Her symptoms resolved, and her medications were re-introduced sequentially over several months. Restarting UQora, however, triggered a recurrence of her symptoms, and it was identified as the culprit medication. Consequently, UQora was permanently discontinued, and the patient has remained symptom-free. CONCLUSIONS: This case report describes the first documented case of serum sickness-like reaction caused by UQora (active ingredient D-mannose). D-mannose is a monosaccharide, and it is frequently promoted to prevent urinary tract infections. While the clinical features and timeline in this case were typical of serum sickness-like reaction, UQora as the trigger was highly unusual. Clinicians should be aware of the diverse triggers of serum sickness-like reaction and the importance of prompt identification and management to enhance patient safety. Further research is necessary to better understand the potential therapeutic applications of D-mannose, as well as the potential risks and interactions.

A Novel Method for Stratification of 30-Day Major Complication Risk Using Body Mass Index Thresholds for Patients Undergoing Total Knee Arthroplasty: A National Cohort of 443,157 Patients.

BACKGROUND: Many organizations have used pre-established body mass index (BMI) cut-offs to guide surgical decision-making. As there have been many improvements in patient optimization, surgical technique, and perioperative care over time, it is important to reassess these thresholds and contextualize them to total knee arthroplasty (TKA). The purpose of this study was to calculate data-driven BMI thresholds that predict significant differences in risk of 30-day major complications following TKA. METHODS: Patients who underwent primary TKA from 2010 to 2020 were identified in a national database. Stratum-specific likelihood ratio (SSLR) methodology was used to determine data-driven BMI thresholds at which the risk of 30-day major complications increased significantly. These BMI thresholds were tested using multivariable logistic regression analyses. A total of 443,157 patients were included, who had a mean age of 67 years (range, 18 to 89 years), mean BMI of 33 (range 19 to 59), and 11,766 (2.7%) patients had a 30-day major complication. RESULTS: SSLR analysis identified four BMI thresholds that were associated with significant differences in 30-day major complications: 19 to 33, 34 to 38, 39 to 50, and 51+. When compared to those who had a BMI between 19 and 33, the odds of sustaining a major complication sequentially and significantly increased by 1.1, 1.3, and 2.1 times (P < .05 for all) for the other thresholds. CONCLUSION: This study identified four data-driven BMI strata using SSLR analysis that were associated with significant differences in the risk of 30-day major complications following TKA. These strata can be used to guide shared decision-making in patients undergoing TKA.

A Novel Method for Stratification of Major Complication Risk Using Body Mass Index Thresholds for Patients Undergoing Total Hip Arthroplasty: A National Cohort of 224,413 Patients.

INTRODUCTION: Elevated body mass index (BMI) is associated with complications following Total Hip Arthroplasty (THA). Since obese individuals are almost 10 times more likely to require THA compared to non-obese individuals, we need to understand the risk-benefit continuum while considering THA in obese patients. We aimed to determine data-driven thresholds for BMI at which the risk of major complications following THA increases significantly. METHODS: Patients were identified in a national database who underwent primary THA from 2010 to 2020. BMI thresholds were identified using the stratum-specific likelihood ratio (SSLR) methodology, which is an adaptive technique that allows for identification of BMI cut-offs, at which the risk of major complications is increased significantly . BMI cutoffs identified using SSLR were used to create a logistic regression model. RESULTS: A total of 224,413 patients were identified with a mean age of 66 ± 10, BMI 32 ± 6.7, and 7,186 (3%) sustained a major complication. BMI thresholds were defined as 19-31, 32-37, 38-49 and 50+. Overall, the absolute risk of major complications increased from 2.9% in the lowest BMI strata to 7.5% in the highest BMI strata. Compared to patients with a BMI between 19-31, the odds of sustaining a major complication sequentially increased by 1.2, 1.6, and 2.5-times for patients in each higher BMI strata (all, P < .05). CONCLUSIONS: We have identified BMI cutoffs using SSLR that categorizes patients into four categories of risk for major complications in a nationally representative patient sample. These thresholds can be used in the surgical decision-making process between patients and surgeons.

Evidence-Based Thresholds for the Volume and Cost Relationship in Total Hip Arthroplasty: Outcomes and Economies of Scale.

BACKGROUND: High-volume surgeons and hospital systems have been shown to deliver higher-value care in several studies. However, no evidence-based volume thresholds for cost currently exist in total hip arthroplasty (THA). The objective of this study was to establish meaningful thresholds in cost for surgeons and hospitals performing THA. A secondary objective was to analyze the market share of THAs for each surgeon and hospital stratifications. METHODS: Using a database of 136,501 patients undergoing THA, we used stratum-specific likelihood ratio analysis of a receiver operating characteristic curve to generate volume thresholds based on costs for surgeons and hospitals. In addition, we examined the relative proportion of annual THA cases performed by each surgeon and hospital stratifications. RESULTS: Stratum-specific likelihood ratio analysis of cost by annual surgeon THA volume produced stratifications at: 0-73 (low), 74-123 (medium), and 124 or more (high). Analysis by annual hospital THA volume produced stratifications at: 0-121 (low), 122-309 (medium), and 310 or more (high). Hospital costs decreased significantly (P < .05) in progressively higher volume stratifications. High-volume centers perform the largest proportion of THA cases (48.6%); however, low volume surgeons perform the greatest share of these cases (44.6%). CONCLUSION: Our study establishes economies of scale in THA by demonstrating a direct relationship between volume and cost reduction. High-volume hospitals are performing the greatest proportion of THAs; however, low-volume surgeons perform the largest share of these cases, which highlights a potential area for enhanced value in the care of patients undergoing THA.

Understanding transformative capacity to boost urban climate adaptation: A Semi-Systematic Literature Review.

Transformative capacity (TC) is key for addressing climate change impacts. It refers to urban areas' ability for profound and intentional change to address current challenges and move towards a more desirable and resilient state. However, its varied applications across disciplines can lead to misunderstandings and implementation challenges. Thus, this Semi-Systematic Literature Review (SSLR) on TC within urban studies from 2016 to 2022 aims to overview and synthesise TC literature and its gaps to inform ongoing debates, intersecting it with climate-related research. The results show an increasing interest in TC within two fields of knowledge: resilience studies and transformative research. The review found TC as a catalyst for transformative actions, promoting sustainable pathways, enhancing resilience, and driving fundamental changes in urban climate adaptation. Finally, the prevailing literature gaps concern the TC concept's fragmentation, excessive research on governance features, and lack of joint research about TC and innovation.

Differentiating Between ß-Lactam-Induced Serum Sickness-Like Reactions and Viral Exanthem in Children Using a Graded Oral Challenge.

BACKGROUND: Serum sickness-like reactions (SSLRs) are defined by the presence of rash (primarily urticaria) and joint complaints (arthralgia/arthritis) that are believed to occur due to a non-IgE-mediated response to medications. However, similar reactions can occur due to viral infections, and it can be difficult to distinguish between the two. This may lead to unnecessary avoidance of the culprit antibiotic. OBJECTIVE: We aimed to evaluate children presenting with suspected SSLRs through a graded oral challenge (GOC). METHODS: All children referred to the Montreal Children's Hospital for potential antibiotic allergy (ß-lactam or other antibiotics) and a clinical presentation compatible with SSLR were recruited for the study between March 2013 and February 2020. A standardized survey with questions on treatment, symptoms, and associated factors was completed, and a GOC (10% and subsequently 90% of the oral antibiotic dose) was conducted. Patients with a negative GOC were contacted annually to query on subsequent antibiotic use. RESULTS: Among 75 patients presenting with suspected SSLRs, the median age was 2.0 years and 46.7% were males. Most reactions were attributed to amoxicillin. Among the 75 patients, 2.7% reacted immediately (within 1 hour) to a GOC and 4.0% had a nonimmediate reaction. Of the 43 patients successfully contacted, 20 reported subsequent culprit antibiotic use of whom 25.0% had a subsequent mild reaction (macular/papular rash). CONCLUSIONS: This is the first and largest pediatric study to assess SSLR using a GOC. Our findings suggest that using a GOC is safe and appropriate for differentiating between ß-lactam-induced SSLR and viral exanthem in this population.

Evaluation of the volume-value relationship in hip fracture care using evidence-based thresholds.

BACKGROUND: Studies have shown high-volume surgeons and hospitals deliver higher value care. The aims of this study were to establish meaningful thresholds defining high-volume surgeons and hospitals performing hip fracture surgery and to examine the relative market share of hip fracture cases using these surgeon and hospital strata. METHODS: We performed a retrospective cohort study in a database of 103,935 patients undergoing hip fracture repair. We generated stratum-specific likelihood ratio (SSLR) models of a receiver operating characteristic (ROC) curve using length of stay (LOS) and cost value metrics. Volume thresholds predictive of decreased LOS and costs for surgeons and hospitals were identified. RESULTS: Analysis of annual surgeon hip fracture volume produced two volume categories for LOS and cost: 0-30 (low) and 31+ (high). Analysis of LOS by annual hospital hip fracture volume produced strata at: 0-59 (low), 60-146 (medium), and 147 or more (high). Analysis of cost by annual hospital volume produced strata at: 0-125 (low) and 126+ (high). LOS and cost both decreased significantly (p < 0.05) in progressively higher volume categories. Low-volume surgeons performed the majority of hip fracture cases, although they were performed at medium- or high-volume centres. CONCLUSIONS: This study demonstrates a direct relationship between volume and value, translating to improvement in hip fracture care delivery for both surgeons and hospitals. Higher volume hospitals while lower volume surgeons perform the majority of hip fracture cases, suggesting optimisation opportunities. However, systems-based practices at the hospital level likely drive value to a greater extent than individual surgeons.

Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis.

BACKGROUND/AIMS: [corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS: The patients with liver tumor or chronic hepatitis indicated for biopsy were prospectively enrolled. LSM was performed on the same day as biopsy. The diagnostic performances of clinical parameters and LSM in predicting HCC presence were compared with the areas under receiver operating characteristics curves (AUROC). The risk of HCC presence was assessed with stratum-specific likelihood ratios (SSLR). The cut-off values and its diagnostic validity were calculated for LSM. RESULTS: A total of 435 patients, including 106 HCC and 329 chronic hepatitis, were enrolled. The AUROC in predicting HCC presence was 0.736, 0.733, 0.594, 0.579 and 0.532 for LSM, alpha-fetoprotein, platelet count, total bilirubin, and aspartate aminotransferase-platelet ratio index, respectively. Multivariate analysis showed liver stiffness was an independent factor for HCC presence (odds ratio 1.07, 95% confidence interval (CI) 1.05-1.09). SSLR for HCC presence by liver stiffness was 0.43 (95% CI 0.32-0.57) in <12 kPa, 1.28 (0.89-1.84) in 12-24 kPa, and 5.94 (3.77-9.35) in >24 kPa. With 12 and 24 kPa as the cut-offs in predicting HCC presence, the sensitivity was 69.8 and 41.5%, respectively. The specificity was 69.6 and 92.7%, respectively. CONCLUSIONS: LSM identified the risk group for HCC presence in chronic hepatitis patients and had high specificity in the prediction of HCC with the cut-off of 24 kPa.