Closed-loop network of skin-interfaced wireless devices for quantifying vocal fatigue and providing user feedback.

Vocal fatigue is a measurable form of performance fatigue resulting from overuse of the voice and is characterized by negative vocal adaptation. Vocal dose refers to cumulative exposure of the vocal fold tissue to vibration. Professionals with high vocal demands, such as singers and teachers, are especially prone to vocal fatigue. Failure to adjust habits can lead to compensatory lapses in vocal technique and an increased risk of vocal fold injury. Quantifying and recording vocal dose to inform individuals about potential overuse is an important step toward mitigating vocal fatigue. Previous work establishes vocal dosimetry methods, that is, processes to quantify vocal fold vibration dose but with bulky, wired devices that are not amenable to continuous use during natural daily activities; these previously reported systems also provide limited mechanisms for real-time user feedback. This study introduces a soft, wireless, skin-conformal technology that gently mounts on the upper chest to capture vibratory responses associated with vocalization in a manner that is immune to ambient noises. Pairing with a separate, wirelessly linked device supports haptic feedback to the user based on quantitative thresholds in vocal usage. A machine learning-based approach enables precise vocal dosimetry from the recorded data, to support personalized, real-time quantitation and feedback. These systems have strong potential to guide healthy behaviors in vocal use.

Electronic Skin: Opportunities and Challenges in Convergence with Machine Learning.

Recent advancements in soft electronic skin (e-skin) have led to the development of human-like devices that reproduce the skin's functions and physical attributes. These devices are being explored for applications in robotic prostheses as well as for collecting biopotentials for disease diagnosis and treatment, as exemplified by biomedical e-skins. More recently, machine learning (ML) has been utilized to enhance device control accuracy and data processing efficiency. The convergence of e-skin technologies with ML is promoting their translation into clinical practice, especially in healthcare. This review highlights the latest developments in ML-reinforced e-skin devices for robotic prostheses and biomedical instrumentations. We first describe technological breakthroughs in state-of-the-art e-skin devices, emphasizing technologies that achieve skin-like properties. We then introduce ML methods adopted for control optimization and pattern recognition, followed by practical applications that converge the two technologies. Lastly, we briefly discuss the challenges this interdisciplinary research encounters in its clinical and industrial transition.

Stretchable and Breathable Electroluminescent Displays Based on Ultrathin Nanocomposite Designs.

Stretchable electroluminescent devices represent an emerging optoelectronic technology for future wearables. However, their typical construction on sub-millimeter-thick elastomers has limited moisture permeability, leading to discomfort during long-term skin attachment. Although breathable textile displays may partially address this issue, they often have distinct visual appearances with discrete emissions from fibers or fiber junctions. This study introduces a convenient procedure to create stretchable, permeable displays with continuous luminous patterns. The design utilizes ultrathin nanocomposite devices embedded in a porous elastomeric microfoam to achieve high moisture permeability. These displays also exhibit excellent deformability, low-voltage operation, and excellent durability. Additionally, the device is decorated with fluorinated silica nanoparticles to achieve self-cleaning and washable capabilities. The practical implementation of these nanocomposite devices is demonstrated by creating an epidermal counter display that allows intimate integration with the human body. These developments provide an effective design of stretchable and breathable displays for comfortable wearing.

Novel Thermoelectric Fabric Structure with Switched Thermal Gradient Direction toward Wearable In-Plane Thermoelectric Generators.

Wearable thermoelectric generators (TEGs) have exhibited great potential to convert the temperature gradient between the human body and the environment into electrical energy for maintenance-free wearable applications. A 2D planar device structure is widely employed for fabricating flexible TEGs due to its simple structure and facile fabrication properties. However, this device configuration is more appropriate for utilizing in-plane temperature differences than the out-of-plane direction, which limits their application in wearable cases since the temperature difference between the human body and the environment is in the out-of-plane direction. To solve this problem, a novel fabric-based TEG structure that can utilize the out-of-plane temperature gradient is proposed in this work. By introducing thermally conductive components in the generator, the out-of-plane temperature difference can be switched to the in-plane direction, which can be further utilized for 2D planar devices in wearable applications. The prepared thermoelectric fabric prototype with only 12 p-type TE legs exhibits a maximum open-circuit voltage of 4.69 mV and an output power of 39.7 nW at a temperature difference of 30 K. This strategy exhibits a high degree of versatility and can be readily applied to other 2D planar TEGs, thus expanding their potential application in wearable technology.

Highly Stretchable, Knittable, Wearable Fiberform Hydrovoltaic Generators Driven by Water Transpiration for Portable Self-Power Supply and Self-Powered Strain Sensor.

The development of excellently stretchable, highly mobile, and sustainable power supplies is of great importance for self-power wearable electronics. Transpiration-driven hydrovoltaic power generator (HPG) has been demonstrated to be a promising energy harvesting strategy with the advantages of negative heat and zero-carbon emissions. Herein, this work demonstrates a fiber-based stretchable HPG with the advantages of high output, portability, knittability, and sustainable power generation. Based on the functionalized micro-nano water diffusion channels constructed by the discarded mask straps (MSs) and oxidation-treated carbon nanomaterials, the applied water can continuously produce electricity during the spontaneous flow and diffusion. Experimentally, when a tiny 0.1 mL of water encounters one end of the proposed HPG, the centimeter-length device can yield a peak voltage of 0.43 V, peak current of 29.5 µA, and energy density of 5.833 mW h cm-3. By efficiently integrating multiple power generation units, sufficient output power can be provided to drive commercial electronic devices even in the stretched state. Furthermore, due to the reversibility of the electrical output during dynamic stretching-releasing, it can passively convert physiological activities and motion behaviors into quantifiable and processable current signals, opening up HPG's application in the field of self-powered wearable sensing.

Recent Advances on Stretchable Aqueous Zinc-Ion Batteries for Wearable Electronics.

The rapid development of wearable electronics has stimulated the pursuit of advanced stretchable power sources. As a promising candidate, stretchable aqueous zinc-ion batteries (AZIBs), have attracted unprecedented attention owing to their intrinsic safety, low cost, environmental benignity, and high performance, and can be endowed with additional functionalities to broaden the applications of wearable electronics. Here, a comprehensive review on the latest advances of stretchable AZIBs is presented. The materials and methods for stretchable components in AZIBs are first summarized, covering current collectors, electrodes, electrolytes/separators, and encapsulating layers. Subsequently, the benefits of the coplanar, fiber-shaped, and sandwiched configurations for stretchable AZIBs are analyzed. Moreover, the additional features integrated into stretchable AZIBs are highlighted. Finally, the challenges and prospects of stretchable AZIBs for wearable applications in the future are proposed.

A Paper-Based Wearable Moist-Electric Generator for Sustained High-Efficiency Power Output and Enhanced Moisture Capture.

Disposable wearable electronics are valuable for diagnostic and healthcare purposes, reducing maintenance needs and enabling broad accessibility. However, integrating a reliable power supply is crucial for their advancement, but conventional power sources present significant challenges. To address that issue, a novel paper-based moist-electric generator is developed that harnesses ambient moisture for power generation. The device features gradients for functional groups and moisture adsorption and architecture of nanostructures within a disposable paper substrate. The nanoporous, gradient-formed spore-based biofilm and asymmetric electrode deposition enable sustained high-efficiency power output. A Janus hydrophobic-hydrophilic paper layer enhances moisture harvesting, ensuring effective operation even in low-humidity environments. This research reveals that the water adsorption gradient is crucial for performance under high humidity, whereas the functional group gradient is dominant under low humidity. The device delivers consistent performance across diverse conditions and flexibly conforms to various surfaces, making it ideal for wearable applications. Its eco-friendly, cost-effective, and disposable nature makes it a viable solution for widespread use with minimal environmental effects. This innovative approach overcomes the limitations of traditional power sources for wearable electronics, offering a sustainable solution for future disposable wearables. It significantly enhances personalized medicine through improved health monitoring and diagnostics.

Reversibly Compressible Silanated Cellulose Nanofibril Aerogel for Triboelectric Taekwondo Scoring Sensors.

The integration of bio-based materials into triboelectric nanogenerators (TENGs) for energy harvesting from human body motions has sparked considerable research attention. Here, a silanated cellulose nanofibril (SCNF) aerogel is reported for structurally reliable TENGs and reversely compressible Taekwondo scoring sensors under repeated impacts. The preparation of the aerogel involves silanizing cellulose nanofibers (CNFs) with vinyltrimethoxysilane (VTMS), following by freeze-drying and post-heating treatment. The SCNF aerogel with crosslinked physico-chemical bonding and highly porous network is found to exhibit superior mechanical strength and reversible compressibility as well as enhanced water repellency and electron-donating ability. The TENG having a tribo-positive SCNF layer exhibits exceptional triboelectric performances, generating a voltage of 270 V, current of 11 µA, and power density of 401.1 mW m-2 under an applied force of 8 N at a frequency of 5 Hz. With its inherent merits in material composition, structural configuration, and device sensitivity, the SCNF TENG demonstrates the capability to seamlessly integrate into a Taekwondo protection gear, serving as an efficient self-powered sensor for monitoring hitting scores. This study highlights the significant potential of a facilely fabricated SCNF aerogel for the development of high-performance, bio-friendly, and cost-effective Bio-TENGs, enabling their application as self-powered wearable devices and sports engineering sensors.

MXene-Deposited Melamine Foam-Based Iontronic Pressure Sensors for Wearable Electronics and Smart Numpads.

Iontronic pressure sensors hold significant potential to emerge as vital components in the field of flexible and wearable electronics, addressing a variety of applications spanning wearable technology, health monitoring systems, and human-machine interactions. This study introduces a novel iontronic pressure sensor structure based on a seamlessly deposited Ti3C2Tx MXene layer onto highly porous melamine foam as parallel plate electrodes and an ionically conductive electrolyte of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide/thermoplastic polyurethane coupled with carbon cloth as current collecting layers for improved sensitivity and high mechanical stability of more than 7000 cycles. MXene-deposited melamine foam-based iontronic pressure sensors (MIPS) showed a high sensitivity of 5.067 kPa-1 in the range of 45-60 kPa and a fast response/recovery time of 28/18 ms, respectively. The high sensitivity, high mechanical stability, and fast response/recovery time of the designed sensor make them highly promising candidates for real-time body motion monitoring. Moreover, sensors are employed as a smart numpad for integration into advanced ATM security systems utilizing machine learning algorithms. This research marks a significant advance in iontronic pressure sensor technology, offering promising avenues for application in wearable electronics and security systems.

NiCo2O4 Nanowires Immobilized on Nitrogen-Doped Ti3C2Tx for High-Performance Wearable Magnesium-Air Batteries.

Flexible magnesium (Mg)-air batteries provide an ideal platform for developing efficient energy-storage devices toward wearable electronics and bio-integrated power sources. However, high-capacity bio-adaptable Mg-air batteries still face the challenges in low discharge potential and inefficient oxygen electrodes, with poor kinetics property toward oxygen reduction reaction (ORR). Herein, spinel nickel cobalt oxides (NiCo2O4) nanowires immobilized on nitrogen-doped Ti3C2Tx (NiCo2O4/N-Ti3C2Tx) are reported via surface chemical-bonded effect as oxygen electrodes, wherein surface-doped pyridinic-N-C and Co-pyridinic-N moieties accounted for efficient ORR owing to increased interlayer spacing and changed surrounding environment around Co metals in NiCo2O4. Importantly, in polyethylene glycol (PVA)-NaCl neutral gel electrolytes, the NiCo2O4/N-Ti3C2Tx-assembled quasi-solid wearable Mg-air batteries delivered high open-circuit potential of 1.5 V, good flexibility under various bent angles, high power density of 9.8 mW cm-2, and stable discharge duration to 12 h without obvious voltage drop at 5 mA cm-2, which can power a blue flexible light-emitting diode (LED) array and red smart rollable wearable device. The present study stimulates studies to investigate Mg-air batteries involving human-body adaptable neutral electrolytes, which will facilitate the application of Mg-air batteries in portable, flexible, and wearable power sources for electronic devices.

A Highly Sensitive and Stretchable Core-Shell Fiber Sensor for Gesture Recognition and Surface Pressure Distribution Monitoring.

This work reports a highly-strain flexible fiber sensor with a core-shell structure utilizes a unique swelling diffusion technique to infiltrate carbon nanotubes (CNTs) into the surface layer of Ecoflex fibers. Compared with traditional blended Ecoflex/CNTs fibers, this manufacturing process ensures that the sensor maintains the mechanical properties (923% strain) of the Ecoflex fiber while also improving sensitivity (gauge factor is up to 3716). By adjusting the penetration time during fabrication, the sensor can be customized for different uses. As an application demonstration, the fiber sensor is integrated into the glove to develop a wearable gesture language recognition system with high sensitivity and precision. Additionally, the authors successfully monitor the pressure distribution on the curved surface of a soccer ball by winding the fiber sensor along the ball's surface.

Recent advances in two-dimensional nanomaterials for sustainable wearable electronic devices.

The widespread adoption of smart terminals has significantly boosted the market potential for wearable electronic devices. Two-dimensional (2D) nanomaterials show great promise for flexible, wearable electronics of next-generation electronic materials and have potential in energy, optoelectronics, and electronics. First, this review focuses on the importance of functionalization/defects in 2D nanomaterials, a discussion of different kinds of 2D materials for wearable devices, and the overall structure-property relationship of 2D materials. Then, in this comprehensive review, we delve into the burgeoning realm of emerging applications for 2D nanomaterial-based flexible wearable electronics, spanning diverse domains such as energy, medical health, and displays. A meticulous exploration is presented, elucidating the intricate processes involved in tailoring material properties for specific applications. Each research direction is dissected, offering insightful perspectives and dialectical evaluations that illuminate future trajectories and inspire fruitful investigations in this rapidly evolving field.

Ambient energy harvesters in wearable electronics: fundamentals, methodologies, and applications.

In recent years, wearable sensor devices with exceptional portability and the ability to continuously monitor physiological signals in real time have played increasingly prominent roles in the fields of disease diagnosis and health management. This transformation has been largely facilitated by materials science and micro/nano-processing technologies. However, as this technology continues to evolve, the demand for multifunctionality and flexibility in wearable devices has become increasingly urgent, thereby highlighting the problem of stable and sustainable miniaturized power supplies. Here, we comprehensively review the current mainstream energy technologies for powering wearable sensors, including batteries, supercapacitors, solar cells, biofuel cells, thermoelectric generators, radio frequency energy harvesters, and kinetic energy harvesters, as well as hybrid power systems that integrate multiple energy conversion modes. In addition, we consider the energy conversion mechanisms, fundamental characteristics, and typical application cases of these energy sources across various fields. In particular, we focus on the crucial roles of different materials, such as nanomaterials and nano-processing techniques, for enhancing the performance of devices. Finally, the challenges that affect power supplies for wearable electronic products and their future developmental trends are discussed in order to provide valuable references and insights for researchers in related fields.

Ink-based textile electrodes for wearable functional electrical stimulation: A proof-of-concept study to evaluate comfort and efficacy.

BACKGROUND: Functional Electrical Stimulation (FES) represents a promising technique for promoting functional recovery in individuals with neuromuscular diseases. Traditionally, current pulses are delivered through self-adhesive hydrogel Ag/AgCl electrodes, which allow a good contact with the skin, are easy-to-use and have a moderate cost. However, skin adherence decreases after a few uses and skin irritations can originate. Recently, textile electrodes have become an attractive alternative as they assure increased durability, easy integration into clothes and can be conveniently cleaned, improving the wearability of FES. However, as various manufacture processes were attempted, their clear validation is lacking. This proof-of-concept study proposes a novel set of ink-based printed textile electrodes and compares them to adhesive hydrogel electrodes in terms of impedance, stimulation performance and perceived comfort. METHODS: The skin-electrode impedance was evaluated for both types of electrodes under different conditions. These electrodes were then used to deliver FES to the Rectus Femoris of 14 healthy subjects to induce its contraction in both isometric and dynamic conditions. This allowed to compare the two types of electrodes in terms of sensory, motor, maximum and pain thresholds, FES-induced range of motion during dynamic tests, FES-induced torque during isometric tests and perceived stimulation comfort. RESULTS: No statistically significant differences were found both in terms of stimulation performance (Wilcoxon test) and comfort (Generalized Linear Mixed Model). CONCLUSION: The results showed that the proposed ink-based printed textile electrodes can be effectively used as alternative to hydrogel ones. Further experiments are needed to evaluate their durability and their response to sterilizability and stretching tests.

Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients.

Capabilities in continuous monitoring of key physiological parameters of disease have never been more important than in the context of the global COVID-19 pandemic. Soft, skin-mounted electronics that incorporate high-bandwidth, miniaturized motion sensors enable digital, wireless measurements of mechanoacoustic (MA) signatures of both core vital signs (heart rate, respiratory rate, and temperature) and underexplored biomarkers (coughing count) with high fidelity and immunity to ambient noises. This paper summarizes an effort that integrates such MA sensors with a cloud data infrastructure and a set of analytics approaches based on digital filtering and convolutional neural networks for monitoring of COVID-19 infections in sick and healthy individuals in the hospital and the home. Unique features are in quantitative measurements of coughing and other vocal events, as indicators of both disease and infectiousness. Systematic imaging studies demonstrate correlations between the time and intensity of coughing, speaking, and laughing and the total droplet production, as an approximate indicator of the probability for disease spread. The sensors, deployed on COVID-19 patients along with healthy controls in both inpatient and home settings, record coughing frequency and intensity continuously, along with a collection of other biometrics. The results indicate a decaying trend of coughing frequency and intensity through the course of disease recovery, but with wide variations across patient populations. The methodology creates opportunities to study patterns in biometrics across individuals and among different demographic groups.

MXene-based electrochemical devices applied for healthcare applications.

The initial part of the review provides an extensive overview about MXenes as novel and exciting 2D nanomaterials describing their basic physico-chemical features, methods of their synthesis, and possible interfacial modifications and techniques, which could be applied to the characterization of MXenes. Unique physico-chemical parameters of MXenes make them attractive for many practical applications, which are shortly discussed. Use of MXenes for healthcare applications is a hot scientific discipline which is discussed in detail. The article focuses on determination of low molecular weight analytes (metabolites), high molecular weight analytes (DNA/RNA and proteins), or even cells, exosomes, and viruses detected using electrochemical sensors and biosensors. Separate chapters are provided to show the potential of MXene-based devices for determination of cancer biomarkers and as wearable sensors and biosensors for monitoring of a wide range of human activities.

Ten years of laser-induced graphene: impact and future prospect on biomedical, healthcare, and wearable technology.

Since its introduction in 2014, laser-induced graphene (LIG) from commercial polymers has been gaining interests in both academic and industrial sectors. This can be clearly seen from its mass adoption in various fields ranging from energy storage and sensing platforms to biomedical applications. LIG is a 3-dimensional, nanoporous graphene structure with highly tuneable electrical, physical, and chemical properties. LIG can be easily produced by single-step laser scribing at normal room temperature and pressure using easily accessible commercial level laser machines and materials. With the increasing demand for novel wearable devices for biomedical applications, LIG on flexible substrates can readily serve as a technological platform to be further developed for biomedical applications such as point-of-care (POC) testing and wearable devices for healthcare monitoring system. This review will provide a comprehensive grounding on LIG from its inception and fabrication mechanism to the characterization of its key functional properties. The exploration of biomedicals applications in the form of wearable and point-of-care devices will then be presented. Issue of health risk from accidental exposure to LIG will be covered. Then LIG-based wearable devices will be compared to devices of different materials. Finally, we discuss the implementation of Internet of Medical Things (IoMT) to wearable devices and explore and speculate on its potentials and challenges.

Fully printed non-contact touch sensors based on GCN/PDMS composites: enabling over-the-bottom detection, 3D recognition, and wireless transmission.

The rapid advancement in intelligent bionics has elevated electronic skin to a pivotal component in bionic robots, enabling swift responses to diverse external stimuli. Combining wearable touch sensors with IoT technology lays the groundwork for achieving the versatile functionality of electronic skin. However, most current touch sensors rely on capacitive layer deformations induced by pressure, leading to changes in capacitance values. Unfortunately, sensors of this kind often face limitations in practical applications due to their uniform sensing capabilities. This study presents a novel approach by incorporating graphitic carbon nitride (GCN) into polydimethylsiloxane (PDMS) at a low concentration. Surprisingly, this blend of materials with higher dielectric constants yields composite films with lower dielectric constants, contrary to expectations. Unlike traditional capacitive sensors, our non-contact touch sensors exploit electric field interference between the object and the sensor's edge, with enhanced effects from the low dielectric constant GCN/PDMS film. Consequently, we have fabricated touch sensor grids using an array configuration of dispensing printing techniques, facilitating fast response and ultra-low-limit contact detection with finger-to-device distances ranging from 5 to 100 mm. These sensors exhibit excellent resolution in recognizing 3D object shapes and accurately detecting positional motion. Moreover, they enable real-time monitoring of array data with signal transmission over a 4G network. In summary, our proposed approach for fabricating low dielectric constant thin films, as employed in non-contact touch sensors, opens new avenues for advancing electronic skin technology.

We've created 3D recognition sensing arrays using a printed method, enabling remote data transmission. We've identified an intriguing interfacial effect in GCN/PDMS doping, opening new possibilities in smart skin technology.

Advancements in MXene Composite Materials for Wearable Sensors: A Review.

In recent years, advancements in the Internet of Things (IoT), manufacturing processes, and material synthesis technologies have positioned flexible sensors as critical components in wearable devices. These developments are propelling wearable technologies based on flexible sensors towards higher intelligence, convenience, superior performance, and biocompatibility. Recently, two-dimensional nanomaterials known as MXenes have garnered extensive attention due to their excellent mechanical properties, outstanding electrical conductivity, large specific surface area, and abundant surface functional groups. These notable attributes confer significant potential on MXenes for applications in strain sensing, pressure measurement, gas detection, etc. Furthermore, polymer substrates such as polydimethylsiloxane (PDMS), polyurethane (PU), and thermoplastic polyurethane (TPU) are extensively utilized as support materials for MXene and its composites due to their light weight, flexibility, and ease of processing, thereby enhancing the overall performance and wearability of the sensors. This paper reviews the latest advancements in MXene and its composites within the domains of strain sensors, pressure sensors, and gas sensors. We present numerous recent case studies of MXene composite material-based wearable sensors and discuss the optimization of materials and structures for MXene composite material-based wearable sensors, offering strategies and methods to enhance the development of MXene composite material-based wearable sensors. Finally, we summarize the current progress of MXene wearable sensors and project future trends and analyses.

MXene-Based Flexible Electrodes for Electrophysiological Monitoring.

The advancement of flexible electrodes triggered research on wearables and health monitoring applications. Metal-based bioelectrodes encounter low mechanical strength and skin discomfort at the electrode-skin interface. Thus, recent research has focused on the development of flexible surface electrodes with low electrochemical resistance and high conductivity. This study investigated the development of a novel, flexible, surface electrode based on a MXene/polydimethylsiloxane (PDMS)/glycerol composite. MXenes offer the benefit of featuring highly conductive transition metals with metallic properties, including a group of carbides, nitrides, and carbonitrides, while PDMS exhibits inherent biostability, flexibility, and biocompatibility. Among the various MXene-based electrode compositions prepared in this work, those composed of 15% and 20% MXene content were further evaluated for their potential in electrophysiological sensing applications. The samples underwent a range of characterization techniques, including electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), as well as mechanical and bio-signal sensing from the skin. The experimental findings indicated that the compositions demonstrated favorable bulk impedances of 280 and 111 Ω, along with conductivities of 0.462 and 1.533 mS/cm, respectively. Additionally, they displayed promising electrochemical stability, featuring charge storage densities of 0.665 mC/cm2 and 1.99 mC/cm2, respectively. By conducting mechanical tests, Young's moduli were determined to be 2.61 MPa and 2.18 MPa, respectively. The composite samples exhibited elongation of 139% and 144%, respectively. Thus, MXene-based bioelectrodes show promising potential for flexible and wearable electronics and bio-signal sensing applications.