1.
Molecules
; 23(9)2018 Sep 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30227644
RESUMO
A novel 2'-F,4'-C-OMeâ»arabinouridine (araU) was successfully synthesized and introduced into oligonucleotides. The oligonucleotide containing 2'-F,4'-C-OMeâ»araU exhibited improved nuclease resistance and RNA hybridizing selective ability relative to 2'-Fâ»araU. In particular, when 2'-F,4'-C-OMeâ»araU inserted into Câ»Hâ¯Fâ»C bonding-favorable 5'â»uridineâ»purineâ»3' steps, the modified oligonucleotide showed remarkable binding affinity and selectivity to RNA complements. Thus, 2'-F,4'-C-OMeâ»araU has valuable antisense properties and can be used as novel chemical modification for antisense therapeutic strategy.