[Wearables in rheumatology]. / Wearables in der Rheumatologie.

As a result of digitalization in medicine wearable computing devices (wearables) are becoming increasingly more important. Wearables are small portable electronic devices with which the user can record data relevant to health, such as number of steps, activity profile, electrocardiogram (ECG), heart and breathing frequency or oxygen saturation. Initial studies on the use of wearables in patients with rheumatological diseases show the opening up of new possibilities for prevention, disease monitoring and treatment. This study provides the current data situation and the implementation of wearables in the discipline of rheumatology. Additionally, future potential fields of application as well as challenges and limits of the implementation of wearables are illustrated.

Signatures of increasing environmental stress in bumblebee wings over the past century: Insights from museum specimens.

Determining when animal populations have experienced stress in the past is fundamental to understanding how risk factors drive contemporary and future species' responses to environmental change. For insects, quantifying stress and associating it with environmental factors has been challenging due to a paucity of time-series data and because detectable population-level responses can show varying lag effects. One solution is to leverage historic entomological specimens to detect morphological proxies of stress experienced at the time stressors emerged, allowing us to more accurately determine population responses. Here we studied specimens of four bumblebee species, an invaluable group of insect pollinators, from five museums collected across Britain over the 20th century. We calculated the degree of fluctuating asymmetry (FA; random deviations from bilateral symmetry) between the right and left forewings as a potential proxy of developmental stress. We: (a) investigated whether baseline FA levels vary between species, and how this compares between the first and second half of the century; (b) determined the extent of FA change over the century in the four bumblebee species, and whether this followed a linear or nonlinear trend; (c) tested which annual climatic conditions correlated with increased FA in bumblebees. Species differed in their baseline FA, with FA being higher in the two species that have recently expanded their ranges in Britain. Overall, FA significantly increased over the century but followed a nonlinear trend, with the increase starting c. 1925. We found relatively warm and wet years were associated with higher FA. Collectively our findings show that FA in bumblebees increased over the 20th century and under weather conditions that will likely increase in frequency with climate change. By plotting FA trends and quantifying the contribution of annual climate conditions on past populations, we provide an important step towards improving our understanding of how environmental factors could impact future populations of wild beneficial insects.

Analysis of social barriers to sustainable innovation and digitisation in supply chain.

Organisations are consistently becoming more and more conscious about sustainability issues that are being raised on various platforms by regulatory bodies and other social activists. Digitisation of supply chains and other technologies like recycling has emerged as one solution that helps achieve sustainability goals by bringing more transparency into the system regarding emissions. Adopting these sustainability and digitisation-related technologies in the supply chain is a major issue, and there are many social issues related to their implementation and adoption. This study aims to identify social barriers to sustainable innovations and digitisation in the supply chain. A total of eight barriers are identified and analysed using BWM and DEMATEL methodologies. The results indicate that work-related circumstances and employment disruptions are the most prominent social barriers, which also influence other barriers. Organisations need to hire and train manpower in skills related to sustainable and digitisation technologies to secure their jobs and facilitate the adoption of these technologies in the supply chain.

The Hybrid Stylus: A Multi-Surface Active Stylus for Interacting with and Handwriting on Paper, Tabletop Display or Both.

The distinct properties and affordances of paper provide benefits that enabled paper to maintain an important role in the digital age. This is so much so, that some pen-paper interaction has been imitated in the digital world with touchscreens and stylus pens. Because digital medium also provides several advantages not available to physical paper, there is a clear benefit to merge the two mediums. Despite the plethora of concepts, prototypes and systems to digitise handwritten information on paper, these systems require specially prepared paper, complex setups and software, which can be used solely in combination with paper, and, most importantly, do not support the concurrent precise interaction with both mediums (paper and touchscreen) using one pen only. In this paper, we present the design, fabrication and evaluation of the Hybrid Stylus. The Hybrid Stylus is assembled with the infinity pencil tip (nib) made of graphite and a specially designed shielded tip holder that is attached to an active stylus. The stylus can be used for writing on a physical paper, while it still maintains all the features needed for tablet interaction. Moreover, the stylus also allows simultaneous digitisation of handwritten information on the paper when the paper is placed on the tablet screen. In order to evaluate the concept, we also add a user-friendly manual alignment of paper position on the underlying tablet computer The evaluation demonstrates that the system achieves almost perfect digitisation of strokes (98.6% of strokes were correctly registered with only 1.2% of ghost strokes) whilst maintaining excellent user experience of writing with a pencil on the paper.

"Inform the Head, Give Dexterity to the Hand, Familiarise the Heart": Seeing and Using Digitised Eighteenth-Century Specimens in a Modern Medical Curriculum.

Recent years have seen an explosion of interest in digitising museum collections. Among the objects of interest are anatomical and pathological specimens found in medical museums. As researchers increasingly produce digital replicas of these preparations, ways of integrating these resources into the medical curriculum must be explored. This article takes a medical humanities approach to this topical question, comparing the historic use of anatomical specimens to modern intentions, and exploring the potential for using digital anatomy to help integrate humanities into the curriculum. The use of anatomical specimens by William Hunter (1718-1783), whose collection is now kept at the Hunterian in the University of Glasgow, provides a key historic focus. The teaching intentions for his private courses of anatomy are examined, to investigate how specimens were used in an eighteenth-century "curriculum". The motivations behind digitisation and the use of digital anatomy in modern curriculums are then examined and compared. Many of these motivations are shared with Hunter's: the desire to maintain a unique anatomical resource, the need to provide multisensory engagement in learning, and a desire to attempt to show "natural" anatomy without the interference of human processes. The balance between fostering empathy and maintaining detachment is also key for both. Using digital replicas of historic specimens to teach anatomy also opens up a unique opportunity to educate students in the medical humanities in a fully integrated way. Understanding the full story of the specimens they use, as explored in the first half of the article, allows students to place themselves, their dissection subjects, and healthcare as a whole in a historical context. As well as fostering empathy in the dissection lab, the stories behind the specimens can be used to introduce key humanities topics, including ethics, institutional bias, and social aspects of health and disease. It is essential that this potential is explored now while digital anatomy is still a relatively young field, and therefore collaborations between anatomists and medical humanities practitioners can be built and included from the ground up.

Improving data acquisition speed and accuracy in sport using neural networks.

Video analysis is used in sport to derive kinematic variables of interest but often relies on time-consuming tracking operations. The purpose of this study was to determine speed, accuracy and reliability of 2D body landmark digitisation by a neural network (NN), compared with manual digitisation, for the glide phase in swimming. Glide variables including glide factor; instantaneous hip angles, trunk inclines and horizontal velocities were selected as they influence performance and are susceptible to digitisation propagation error. The NN was "trained" on 400 frames of 2D glide video from a sample of eight elite swimmers. Four glide trials of another swimmer were used to test agreement between the NN and a manual operator for body marker position data of the knee, hip and shoulder, and the effect of digitisation on glide variables. The NN digitised body landmarks 233 times faster than the manual operator, with digitising root-mean-square-error of ~4-5 mm. High accuracy and reliability was found between body position and glide variable data between the two methods with relative error ≤5.4% and correlation coefficients >0.95 for all variables. NNs could be applied to greatly reduce the time of kinematic analysis in sports and facilitate rapid feedback of performance measures.

Country-level assessment of agrifood waste and enabling environment for sustainable utilisation for bioenergy in Nigeria.

It is essential to plug inefficiencies due to agrifood losses and wastes, which pose a significant threat to the sustainable supply of nutritional agrifood commodities/products. Country-specific evaluations of the extent of agrifood losses/wastes, including the pathways and impacts on net agrifood production, are crucial to inform interventions, research, policies and investments. This kind of knowledge is scarce in sub-Saharan Africa (SSA) countries, many of which are food insecure. This paper presents an estimation of and the bioenergy potential for agrifood loss and waste (AFW) - the edible and inedible residual biogenic fractions of crops and animal commodities/products - in Nigeria. Our findings reveal that Nigeria generates 183.3 ± 8.9MT of AFW per annum. About 27% of the average annual total domestic supply of edible agrifood commodities/products is lost before reaching markets/consumers. The intrinsic bioenergy potential of the inedible AFW fraction generated annually in Nigeria is estimated to be 1,816.8 ± 117.3PJ; this is sufficient to meet 2030's bioenergy targets and replace a third of its total (grid, off-grid and self-generation) supply targets. However, Nigeria lacks regulatory, policy and institutional frameworks specific to AFW management. This study recommends a sustainable approach to managing AFW, addressing the interlinked challenges of bioenergy production, public health and environmental sustainability. Besides addressing knowledge gaps in the Nigerian agrifood sector, the information generated in this study is well-timed to inform decision-making and policy formulation on decentralised AFW-based bioenergy interventions to achieve energy supply targets in the country by 2030 and beyond. This study is also strategic to guide future research/interventions that align with AFW utilisation/clean energy generation in SSA.

Consolidating strategic information to monitor progress against the UNAIDS 90-90-90 targets: evaluating the operational feasibility of an electronic HIV testing register in Cape Town, South Africa.

BACKGROUND: HIV diagnosis in South Africa is based on a point-of-care testing (PoCT) algorithm with paper-based record-keeping. Aggregated testing data are reported routinely. To facilitate improved HIV case-based surveillance, the Western Cape Province implemented a unique pilot intervention to digitise PoCT results, at an individual level, and generate an electronic register using the newly developed Provincial Health Data Centre (PHDC). We describe the intervention (phased) and present an evaluation of the operational feasibility of the intervention. We also offer implementation insights into establishing electronic capture of individual level testing data. METHODS: Cross-sectional analyses were conducted on records of all patients attending a local Community Health Centre who had an HIV-PoCT during the study period. Data from the intervention were linked to the PHDC using a unique identifier and compared with aggregate data from the paper-based register. Correlation coefficients were calculated to quantify the correlation between the two monthly datasets. To support an understanding of the findings, the Department of Health project management team generated reflections on the implementation process, which were then grouped thematically into implementation lessons. RESULTS: In total, 11,337 PoCT records were digitised (70% (7954) during Phase I; and 30% (3383) during Phase II). Linkage of forms to the PHDC was 96% in Phase I and 98% in Phase II. Comparison with aggregate data showed high correlation during Phase I, but notable divergence during Phase II. Divergence in Phase II was due to stringent data quality requirements and high clinical staff turnover. Factors supporting implementation success in Phase I included direct oversight of data capturing by a manager with clinical and operational insight. Implementation challenges included operational, health system, and high cost-related issues. CONCLUSIONS: We demonstrate that rapid digitisation of HIV PoCT data, without compromising currently collected aggregate data, is operationally feasible, and can contribute to person-level longitudinal HIV case-based surveillance. To take to scale, we will need to improve PoCT platforms and clerical and administrative systems. Although we highlight challenges, we demonstrate that electronic HIV testing registers can successfully replace manual registers and improve efforts to monitor and evaluate HIV testing strategies.

Virtual Anatomy Museum: Facilitating Public Engagement Through an Interactive Application.

Digitisation has become a common practice in the preservation of museum collections. Recent development of photogrammetry techniques allows for more accessible acquisition of three-dimensional (3D) models that serve as accurate representations of their originals. One of the potential applications of this is presenting digital collections as virtual museums to engage the public. Medical museums, particularly, would benefit from digitisation of their collections as many of them are closed to the public.The aim of this project was to design and create an interactive virtual museum which would represent the Anatomy Museum at the University of Glasgow with key specimens digitised using photogrammetry techniques. Members of the general public (25 participants) were asked to evaluate the usability and effectiveness of the interactive application by completing questionnaires.A process to digitise anatomical specimens using photogrammetry and convert them into game-ready 3D models was developed. The results demonstrated successful generation of 3D models of specimens preserved using different techniques, including specimens preserved in fluid and glass jars. User tests and evaluation of the application by members of the general public were positive, with participants agreeing that they would now consider visiting the real museum after using the virtual version.

Delivering healthcare's 'triple aim': electronic health records and the health research participant in the UK National Health Service.

The UK National Health Service (NHS) is changing. Consecutive UK industrial strategies have supported the shift from an NHS that provides free-at-point-of-delivery healthcare to one that also facilitates research. Said to promote healthcare's triple aim of 'better health, better healthcare, and lower cost' (Wachter, 2016, 3), the digitisation of patient records is a core part in opening routine aspects of the health system to potential research. In this paper, we thematically analyse 11 policy documents and ask, how does the NHS discuss its decision to digitise patient records and what are the implications of such practices on the citizen? We document how (1) digitisation is presented as a collective endeavour for patients and NHS professionals, offering new possibilities for patients to participate in their own health and that of the population through research and, (2) digitisation contributes to the building of an efficient health system. Through this analysis we reflect on how discussions of digitisation present uncritically the potential of Electronic Health Records and big data analytics to improve care and generate wealth through research, and reconfigure patienthood, by placing research participation as a routine part of accessing NHS healthcare.

The human element in future Maritime Operations - perceived impact of autonomous shipping.

The role of the human element within complex socio-technical systems is continually being transformed and redefined by technological advancement. Autonomous operations across varying transport domains are in differing stages of realisation and practical implementation, and specifically within maritime operations, is still in its infancy. This study explores the potential effects of autonomous technologies on future work organisation and roles of humans within maritime operations. Ten Subject-Matter Experts working within industry and academia were interviewed to elicit their perspectives on the current state and future implications of autonomous technologies. Four main themes emerged: (i) Trust, (ii) Awareness and Understanding, (iii) Control, (iv) Training and Organisation of Work. A fuzzier fifth theme also appeared in the data analysis: (v) Practical Implementation Considerations, which encompassed various sub-topics related to real-world implementation of autonomous ships. The results provide a framework of human element issues relevant for the organisation and implementation of autonomous maritime operations. Practitioner summary: As autonomous shipping rapidly moves closer to real-world implementation, it is critical to develop an understanding of future roles of humans in autonomous maritime operations. By eliciting expert knowledge from academics and practitioners, we establish a framework of relevant issues facing humans in emerging autonomous systems and operations at sea.

Visualising Medical Heritage: New Approaches to Digitisation and Interpretation of Medical Heritage Collections.

New approaches to digitisation and interpretation of the heritage collections at the Royal College of Physicians and Surgeons of Glasgow (RCPSG) have been developed in partnership with the Anatomy Facility at the University of Glasgow. Drawing upon the work of the Medical Visualisation and Human Anatomy MSc programme at the University and The Glasgow School of Art, the approach of RCPSG has been to utilise innovative medical visualisation methods to provide an enhanced level of access to their museum collections. This chapter will discuss how this approach has opened up a wide range of possibilities for how these challenging objects can be interpreted and engaged with. It will outline how visualisation methods such as 3D digital modelling, photogrammetry, augmented reality, and animation can unlock the stories of scientific innovation, of the evolution of medical and surgical care, and of the wider social and cultural context of medical heritage.

Data mobilisation in the LWS Herbarium: success and prospects.

Background: Digitisation of hosted specimens is a crucial task for all herbaria worldwide and is one of the main streams for today. By digitising their collections and publishing the datasets, the herbaria grant access to essential data to a wide research audience and, as a result, involve their collections in scientific work more actively. Digitisation also allows virtual preservation of the collections, which is especially important in conditions of hostilities, when the entire collection can be destroyed or damaged in one moment. This paper describes two datasets recently published in GBIF in the framework of the LWS herbarium digitisation initiative. It also contains some considerations about further digitisation priorities and plans in the LWS Herbarium in the context of complicated war conditions and limited facilities. New information: In total, 2,419 occurrence records from Ukraine mobilised from LWS Herbarium were published. These datasets are planned to be dynamic with the addition of new records along with progress of digitisation work at LWS. At least 6,000 more records are planned to be published through these datasets in 2024.

Epistemic domination by data extraction: questioning the use of biometrics and mobile phone data analysis in asylum procedures.

In a growing number of destination countries state authorities have started to use various digital devices such as analysis of data captured from mobile phones to verify asylum seekers' claimed country of origin. This move has prompted some critics to claim that asylum decision-making is increasingly delegated to machines. Based on fieldwork at a reception centre in Germany, this paper mobilises insights from science and technology studies (STS) to develop a framework that allows for more nuanced analyses and modes of critiques of the digitisation of asylum procedures. Rather than thinking human and non-human forms of agency as external to one another in order to juxtapose them in a zero-sum game, I comprehend the introduction of digital technologies as a reconfiguration of existing human-machine configurations. This conception highlights how the use digital technologies enables caseworkers to retain their position as an epistemic authority in asylum decision-making by assembling clues about asylum seekers' country of origin generated by digital technologies into hard juridical evidence. Subsequently, I develop an alternative critique that focuses on epistemic implications of the digitisation of asylum procedures. I identify a particular version of data colonialism that enables epistemic domination by means of data extraction.

Reappraisal of sauropod dinosaur diversity in the Upper Cretaceous Winton Formation of Queensland, Australia, through 3D digitisation and description of new specimens.

Skeletal remains of sauropod dinosaurs have been known from Australia for over 100 years. Unfortunately, the classification of the majority of these specimens to species level has historically been impeded by their incompleteness. This has begun to change in the last 15 years, primarily through the discovery and description of several partial skeletons from the Cenomanian-lower Turonian (lower Upper Cretaceous) Winton Formation in central Queensland, with four species erected to date: Australotitan cooperensis, Diamantinasaurus matildae, Savannasaurus elliottorum, and Wintonotitan wattsi. The first three of these appear to form a clade (Diamantinasauria) of early diverging titanosaurs (or close relatives of titanosaurs), whereas Wintonotitan wattsi is typically recovered as a distantly related non-titanosaurian somphospondylan. Through the use of 3D scanning, we digitised numerous specimens of Winton Formation sauropods, facilitating enhanced comparison between type and referred specimens, and heretofore undescribed specimens. We present new anatomical information on the holotype specimen of Diamantinasaurus matildae, and describe new remains pertaining to twelve sauropod individuals. Firsthand observations and digital analysis enabled previously proposed autapomorphic features of all four named Winton Formation sauropod species to be identified in the newly described specimens, with some specimens exhibiting putative autapomorphies of more than one species, prompting a reassessment of their taxonomic validity. Supported by a specimen-level phylogenetic analysis, we suggest that Australotitan cooperensis is probably a junior synonym of Diamantinasaurus matildae, but conservatively regard it herein as an indeterminate diamantinasaurian, meaning that the Winton Formation sauropod fauna now comprises three (rather than four) valid diamantinasaurian species: Diamantinasaurus matildae, Savannasaurus elliottorum, and Wintonotitan wattsi, with the latter robustly supported as a member of the clade for the first time. We refer some of the newly described specimens to these three species and provide revised diagnoses, with some previously proposed autapomorphies now regarded as diamantinasaurian synapomorphies. Our newly presented anatomical data and critical reappraisal of the Winton Formation sauropods facilitates a more comprehensive understanding of the mid-Cretaceous sauropod palaeobiota of central Queensland.

An annotated catalogue of selected historical type specimens, including genetic data, housed in the Natural History Museum Vienna.

Museum collections are an important source for resolving taxonomic issues and species delimitation. Type specimens as name-bearing specimens, traditionally used in morphology-based taxonomy, are, due to the progress in historical DNA methodology, increasingly used in molecular taxonomic studies. Museum collections are subject to constant deterioration and major disasters. The digitisation of collections offers a partial solution to these problems and makes museum collections more accessible to the wider scientific community. The Extended Specimen Approach (ESA) is a method of digitisation that goes beyond the physical specimen to include the historical information stored in the collection. The collections of the Natural History Museum Vienna represent one of the largest non-university research centres in Europe and, due to their size and numerous type specimens, are frequently used for taxonomic studies by visiting and resident scientists. Recently, a version of ESA was presented in the common catalogue of the Fish and Evertebrata Varia collections and extended to include genetic information on type specimens in a case study of a torpedo ray. Here the case study was extended to a heterogeneous selection of historical type series from different collections with the type locality of Vienna. The goal was to apply the ESA, including genetic data on a selected set of type material: three parasitic worms, three myriapods, two insects, twelve fishes, and one bird species. Five hundred digital items (photographs, X-rays, scans) were produced, and genetic analysis was successful in eleven of the 21 type series. In one case a complete mitochondrial genome was assembled, and in another case ten short fragments (100-230 bp) of the cytochrome oxidase I gene were amplified and sequenced. For five type series, genetic analysis confirmed their taxonomic status as previously recognised synonyms, and for one the analysis supported its status as a distinct species. For two species, genetic information was provided for the first time. This catalogue thus demonstrates the usefulness of ESA in providing digitised data of types that can be easily made available to scientists worldwide for further study.

Ten lessons learned from the mass digitisation of a herbarium collection.

Worldwide, herbaria maintain collections of reference specimens representing global plant diversity. These collections are a valuable resource for fundamental botanical research and applied scientific research across various disciplines, and play a significant role in addressing major societal challenges such as biodiversity conservation. The digitisation of herbarium specimens and their online dissemination is one of the most important recent developments in the curation of these collections. Digitisation significantly enhances access to the collections for the research community and facilitates large-scale analysis of biodiversity data. Digitisation also provides a means for preserving the physical specimens, as it reduces the need for handling and transportation. Rapid technological developments have greatly accelerated the rate of databasing and digital imaging of collections. Meise Botanic Garden recently completed a six-year project to mass digitise its herbarium collections of about 3 million specimens mounted on sheets and through this process we have learned valuable lessons. We have captured our experience in 10 recommendations for other collection-holding institutions to take inspiration from as they start planning their own digitisation efforts. We also present case studies where we delve deeper into certain topics as examples.

From physical to digital: A theoretical-methodological primer on designing hyperscanning investigations to explore remote exchanges.

As individuals increasingly engage in social interactions through digital mediums, understanding the neuroscientific underpinnings of such exchanges becomes a critical challenge and a valuable opportunity. In line with a second-person neuroscience approach, understanding the forms of interpersonal syntonisation that occur during digital interactions is pivotal for grasping the mechanisms underlying successful collaboration in virtual spaces. The hyperscanning paradigm, involving the simultaneous monitoring of the brains and bodies of multiple interacting individuals, seems to be a powerful tool for unravelling the neural correlates of interpersonal syntonisation in social exchanges. We posit that such approach can now open new windows on interacting brains' responses even to digitally-conveyed social cues, offering insights into how social information is processed in the absence of traditional face-to-face settings. Yet, such paradigm shift raises challenging methodological questions, which should be answered properly to conduct significant and informative hyperscanning investigations. Here, we provide an introduction to core methodological issues dedicated to novices approaching the design of hyperscanning investigations of remote exchanges in natural settings, focusing on the selection of neuroscientific devices, synchronization of data streams, and data analysis approaches. Finally, a methodological checklist for devising robust hyperscanning studies on digital interactions is presented.

A Comprehensive Review on Virtual Articulators.

The virtual articulator (VA) is a technology that simulates the jaw relation in a computer-generated setting. Augmented and virtual reality have been utilized as digital technology, which aids in many areas of dentistry and dental education. Today, a practicing dentist must keep up with the newer technologies, but with technology evolving so quickly it becomes challenging. In dentistry, the possibilities for digitization and technological advancements are limitless. Virtual articulators (VAs) allow a complete occlusion analysis using dental models that replicate all mandibular motions in static and dynamic scenarios. VA when executed in addition to other software enhances treatment planning and patient education, allowing quicker and more precise individualized diagnoses. The main objective of this study was to describe and evaluate the study outcomes in the available research on VAs, assess their needs, and evaluate their advantages and limitations in various aspects. A PubMed Central search was made of dental journals, with the identification of 135 articles out of which 30 were finally selected. The investigations conducted to evaluate the VA's dependability provide good visualization of the quantity and location of the dynamic interactions. A precise instrument for fully analyzing occlusion in a real patient is the virtual articulator.

Erratum: Health in Germany: Establishment of a population-based health panel.

[This corrects the article on p. 2,21 in vol. 9, PMID: 38282983.].