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Cell Rep ; 41(1): 111446, 2022 10 04.
Artigo em Inglês | MEDLINE | ID: mdl-36198267

RESUMO

The plateau pika (Ochotona curzoniae) is native to the Qinghai-Tibet Plateau. In this study, the gene that encodes a heme-binding protein in the pulmonary surfactant (PS) of the pika is identified. The protein is a homotetrameric hemoglobin (δ4) encoded by HBD (δ). HBD is expressed in alveolar epithelial type II (ATII) and type I (ATI) cells, upregulated by hypoxia. δ4 is secreted into alveolar cavities through osmiophilic multilamellar bodies. HBD expression is downregulated by RNAi, which significantly increases hypoxia-inducible factor 1α expression in lung tissue and red blood cells and hemoglobin and blood lactate concentrations but significantly decreases arterial partial pressure of oxygen (PaO2). Our results indicate that plateau pikas physiologically show hypoxemia when HBD expression is downregulated. Therefore, specific HBD expression in the lungs helps plateau pikas to obtain oxygen under hypoxia by maintaining higher PaO2. These findings provide insights into the adaptive mechanisms of plateau pikas to withstand high-altitude environments.


Assuntos
Lagomorpha , Surfactantes Pulmonares , Altitude , Células Epiteliais Alveolares/metabolismo , Animais , Proteínas Ligantes de Grupo Heme , Hemoglobinas/metabolismo , Hipóxia/metabolismo , Lactatos/metabolismo , Lagomorpha/genética , Lagomorpha/metabolismo , Pulmão/metabolismo , Oxigênio/metabolismo , Surfactantes Pulmonares/metabolismo
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