Barriers to commercial deployment of biorefineries: A multi-faceted review of obstacles across the innovation chain.

Realizing integrated biorefineries producing multiple fuels, chemicals and materials from sustainable biomass feedstocks holds promise for transitioning industries onto low-carbon trajectories. However, widespread commercial implementation remains elusive despite two decades of technological advancements. This review synthesizes current literature to provide a comprehensive analysis of key multi-dimensional barriers inhibiting the scale-up of biorefineries. The review discusses the technical challenges around biomass conversion processes. Economic viability concerns such as high capital costs and lack of market competitiveness are also assessed. The review also evaluates the regulatory and policy complexities that poses risks and uncertainties in the scaling up of biorefineries. Socio-political acceptance hurdles including community engagement and public perception are also reviewed. The interconnected nature of these challenges is emphasized and strategies are recommended to enable full potential realization, covering areas such as enhanced stakeholder collaboration, advanced process intensification, supportive policy frameworks, innovative financing models and strategic marketing initiatives. International pilots and cross-sectoral knowledge exchange are highlighted as priority enablers. In conclusion, this review synthesizes insights from extensive demonstration efforts to identify priorities and pathways for accelerating the global commercial transition towards sustainable biorefinery implementation. It aims to inform strategic decision-making and collaborative actions amongst stakeholders in research, industry and policy domains.

Challenges in the Implementation of Disruptive Innovations in Health Care Organizations.

Health organizations face barriers when seeking to deploy radical innovations, such as innovative telemonitoring approaches or AI based Clinical Decision Support Systems (CDSS) into their clinical workflow. However, these barriers are of various types and rarely known to organizations and their management. This study conducted a systematic literature review of 99 selected studies to identify the implementation barriers and factors encountered in this process. Using a hierarchical framework comprising of strategies, resources and capabilities, and processes, the study examined 16 barriers generated from the analysis of the individual studies. The findings highlight implementation barriers on all three levels of the proposed framework. By addressing these barriers comprehensively, health care organizations can successfully implement radical health innovations and enhance patient care outcomes and health care delivery.

Adoption of Digital Vaccination Services: It Is the Click Flow, Not the Value-An Empirical Analysis of the Vaccination Management of the COVID-19 Pandemic in Germany.

This research paper examines the adoption of digital services for the vaccination during the COVID-19 pandemic in Germany. Based on a survey in Germany's federal state with the highest vaccination rate, which used digital vaccination services, its platform configuration and adoption barriers are analyzed to understand existing and future levers for optimizing vaccination success. Though technological adoption and resistance models have been originally developed for consumer-goods markets, this study gives empirical evidence especially for the applicability of an adjusted model explaining platform adoption for vaccination services and for digital health services in general. In this model, the configuration areas of personalization, communication, and data management have a remarkable effect to lower adoption barriers, but only functional and psychological factors affect the adoption intention. Above all, the usability barrier stands out with the strongest effect, while the often-cited value barrier is not significant at all. Personalization is found to be the most important factor for managing the usability barrier and thus for addressing the needs, preferences, situation, and, ultimately, the adoption of the citizens as users. Implications are given for policy makers and managers in such a pandemic crisis to focus on the click flow and server-to-human interaction rather than emphasizing value messages or touching traditional factors.

Innovation management involvement among persons with disabilities in Malaysia.

BACKGROUND: As Malaysia struggles with the battle to retain talented workers, the retention of persons with disabilities (PWDs) remains a major challenge in innovation management. Malaysia currently has the lowest retention of PWDs in innovation management in The Association of Southeast Asian Nations (ASEAN). The purpose of this study is to develop a unique framework to enhance the inclusion of PWDs in Malaysia.  Methods: A questionnaire was distributed to 200 PWDs in the central region of Malaysia.   Results: Based on the results of this research, four crucial variables (salary, compensation, career advancement and reward management) contributed to the lack of involvement in innovation management among PWDs in Malaysia.  Conclusions: This study only focuses on 200 PWDs in Malaysia. Despite the fact that PWDs' involvement in innovation management is the lowest, there is a lack of research initiative and practitioner commitment to address this issue. Serving as preliminary research in Malaysia, this study develops a unique framework to fill the gap.

Barriers Influencing Vaccine Development Timelines, Identification, Causal Analysis, and Prioritization of Key Barriers by KOLs in General and Covid-19 Vaccine R&D.

A frequently mentioned factor holding back the introduction of new vaccines on the market are their prohibitively long development timelines. These hamper their potential societal benefit and impairs the ability to quickly respond to emerging new pathogens. This is especially worrisome since new pathogens are emerging at all-time high rates of over one per year, and many age-old pathogens are still not vaccine preventable.Through interviews with 20 key-opinion-leaders (KOLs), this study identified innovation barriers that increase vaccine development timelines. These innovation barriers were visualized, and their underlying causes revealed by means of qualitative root cause analysis. Based on a survey the innovation barriers were quantitatively ranked based on their relative impact on both regular, and Covid-19 vaccine development timelines. KOLs identified 20 key innovation barriers, and mapping these barriers onto the Vaccine Innovation Cycle model revealed that all phases of vaccine development were affected. Affected by most barriers is the area between the preclinical studies and the market entry. Difficult hand-off between academia and industry, lack of funding, and lack of knowledge of pathogen targets were often mentioned as causes. Quantitative survey responses from 93 KOLs showed that general vaccine development and Covid-19 vaccine development are impacted by distinct sets of innovation barriers. For the general vaccine development three barriers were perceived of the highest impact; limited ROI for vaccines addressing disease with limited market size, limited ROI for vaccines compared to non-vaccine projects, and academia not being able to progress beyond proof of principle. Of highest impact on Covid-19 vaccine development, are lack of knowledge concerning pathogen target, high risk of upscaling unlicensed vaccines, and proof of principle not meeting late-stage requirements. In conclusion, the current study demonstrates that barriers hampering timelines in vaccine development are present across the Vaccine Innovation Cycle. Prioritizing the impact of barriers in general, and in Covid-19 vaccine development, shows clear differences that can be used to inform policies to speed up development in both war and peace time.

Systems Medicine: hype or revolution?

Research and innovation in healthcare can change existing practices aiming at constant improvement of diagnosis, treatment and prevention. As a new holistic approach Systems Medicine (SM) may revolutionize the healthcare system. This paper analyzes ethical and economic obstacles of SMs development from a niche innovation to a standard solution. We adapt a model of innovation theory to structure the barriers of adopting SM to become standard in the medical system. SM has the potential to change the medical system if barriers to this innovation can be overcome. The article discusses the potential of SM in becoming the future health paradigm considering these barriers and provides an overview of the current situation.