Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial.

Sonidegib, a hedgehog pathway inhibitor, was approved by the US FDA for the treatment of locally advanced basal cell carcinoma which cannot be readily treated with surgery or radiotherapy. The pharmacology and pharmacokinetics of sonidegib will be discussed in this review. Additionally, an in-depth analysis of the BOLT trial and data from the 30-month update will be included. This will serve as an update to a previously published article which reported the 12-month update of the BOLT trial.

Ammonium removal from aqueous solutions by fixed-bed column using corncob-based modified biochar.

This study investigated the potential of removing ammonium ([Formula: see text]) from aqueous solutions using corncob based on modified biochar (MBCC) in the fixed-bed column. Corncob biochar was soaked in a mixture of HNO3 6.0 M and NaOH 0.3 M to prepare active binding sites for ammonium removal. The effect of initial ammonium concentrations (10-40 mg/L), flow rates (1-9 mL/min) and MBCC fixed-bed heights (8-24 cm) on the breakthrough characteristics of the adsorption system were studied. The results showed that the highest adsorption capacity of fix-bed column, the breakthrough time and value of Ct/Co were 12.83 mg/g, 480 min and 0.862 ± 0.025 at 10 mg/L of initial ammonium concentration, 8 cm of MBCC fixed-bed height and 3 mL/min of flow rate, respectively. The breakthrough curve model in this study also indicated that all Yoon-Nelson, Thomas and Adam-Bohart models well fit with the experimental data with a high R2. The results also proved that MBCC can be used as a potential adsorbent for eliminating [Formula: see text] in the fixed-bed column. The saturated MBCC was also regenerated and reused consecutively for four cycles. The usage of mixture of NaOH and NaCl in recovering MBCC was better than NaCl only.