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Proc Natl Acad Sci U S A ; 121(27): e2314291121, 2024 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-38923990

RESUMO

Networks involved in information processing often have their nodes arranged hierarchically, with the majority of connections occurring in adjacent levels. However, despite being an intuitively appealing concept, the hierarchical organization of large networks, such as those in the brain, is difficult to identify, especially in absence of additional information beyond that provided by the connectome. In this paper, we propose a framework to uncover the hierarchical structure of a given network, that identifies the nodes occupying each level as well as the sequential order of the levels. It involves optimizing a metric that we use to quantify the extent of hierarchy present in a network. Applying this measure to various brain networks, ranging from the nervous system of the nematode Caenorhabditis elegans to the human connectome, we unexpectedly find that they exhibit a common network architectural motif intertwining hierarchy and modularity. This suggests that brain networks may have evolved to simultaneously exploit the functional advantages of these two types of organizations, viz., relatively independent modules performing distributed processing in parallel and a hierarchical structure that allows sequential pooling of these multiple processing streams. An intriguing possibility is that this property we report may be common to information processing networks in general.


Assuntos
Encéfalo , Caenorhabditis elegans , Conectoma , Rede Nervosa , Encéfalo/fisiologia , Encéfalo/anatomia & histologia , Animais , Conectoma/métodos , Humanos , Rede Nervosa/fisiologia , Modelos Neurológicos
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