Safety and Effectiveness of Acceleration Training as Cardiac Rehabilitation Immediately After Open Heart Surgery　- A Pilot Study.

BACKGROUND: We examined the safety and efficacy of acceleration training (AT) in patients immediately after cardiac surgery.Methods and Results: This randomized controlled study included patients who underwent open-heart surgery using cardiopulmonary bypass. Of these patients, 31 received regular cardiac rehabilitation (CR) and 39 received AT in addition to regular CR (AT group). AT was provided using a vibration platform (Power Plate®Pro7TMand Power plate®personal; Performance Health System, Chicago, IL, USA). The AT group performed 5 static resistance training sessions: squats, wide stance squats, toe stands, banded squats, and front lunges. Each vibration session lasted 30 s. We evaluated the short physical performance battery, anterior mid-thigh thickness, maximum voluntary isometric contraction of the knee extensors, and serum intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) concentrations as indicators of endothelial function. The observation period was during hospitalization and lasted approximately 20 days. No adverse events occurred during AT. Ultrasound revealed a significantly lower reduction in muscle mass at discharge in the AT group. No significant differences were observed in ICAM-1 and VCAM-1 concentrations between the 2 groups preoperatively, postoperatively, or at discharge. CONCLUSIONS: AT is considered safe and effective for patients immediately after open-heart surgery. AT, along with regular CR, may prevent skeletal muscle mass loss, muscle weakness, and physical function loss immediately after open-heart surgery.

Trunk-oriented Exercises Versus Whole-body Vibration on Abdominal Thickness and Balance in Children with Duchene Muscular Dystrophy.

OBJECTIVES: Progressive proximal muscle weakening in children with Duchenne muscular dystrophy (DMD) impairs postural adjustments by impairing motor function and preventing ambulation. During daily activities, for gait and dynamic balance, certain postural modifications are required. The objective was to compare the impact of trunk-oriented exercises versus whole-body vibration on abdominal muscle thickness and balance in children with DMD. METHODS: Participants in this study were 30 boys with DMD, aged 6 to 10 years old. Children were divided into two groups (A and B) randomly. Children in group (A) underwent a prescribed regimen of physical therapy along with trunk-oriented exercises, whereas group (B) received the same regimen as group (A) together with whole-body vibration three times per week for three consecutive months. Balance and the thickness of the abdominal muscles were measured using the Biodex balance system and ultrasonography, respectively, before and after therapy. RESULTS: When compared to the pre-treatment results in both groups, the post-treatment results showed a significant difference in all measured variables (p<0.05). Post-treatment values showed that all of the measured variables significantly differed in favor of group A. CONCLUSIONS: Trunk-oriented exercises can improve abdominal thickness and balance more effectively than whole-body vibration in children with DMD. CLINICALTRIALS: gov ID: NCT05688072.

Motor improvement in children with PMM2-CDG syndrome following a six-month rehabilitation treatment utilising whole-body vibration; a retrospective study.

OBJECTIVE: The aim of this study was to assess the effect of a six-month interval rehabilitation treatment on motor function of children with PMM2-CDG syndrome (#212065 Congenital disorder of glycosylation, Type Ia; CDG1A, OMIM catalogue number). METHODS: The concept 'Auf die Beine' (Center for Prevention and Rehabilitation of the University of Cologne, Germany) combines two short inpatient stays (1 to 2 weeks) with a six-month whole-body vibration (WBV) home-training program. 13 patients with PMM2-CDG syndrome participated in this concept from 2006 until 2015. Assessments at start, six months and 12 months (follow-up): Gross Motor Function Measure (GMFM-66), One-Minute Walk Test (1MWT) and instrumented gait analyses. RESULTS: The GMFM-66 (9 of 13 children) improved by 5.3 (mean) points (SD 3.2) at 12 months (p=0.0039). The 1MWT (6 of 13 children) improved by 19.17 meter (SD 16.51) after 12 months (p=0.0313). Gait analysis (9 of 13 children) measured by pathlength/distance ratio improved by -0.8 (SD 1.9) at 12 months (p=0.0195). CONCLUSION: Patients with PMM2-CDG syndrome benefit from the interval rehabilitation program 'Auf die Beine' including WBV.

Effects of whole-body vibration exercise on physical function in patients with chronic kidney disease: a systematic review and meta-analysis.

BACKGROUND: The current state of knowledge regarding the efficacy of whole-body vibration (WBV) training for individuals with chronic kidney disease (CKD) is limited. To address this gap, the present study seeks to undertake a comprehensive systematic review and meta-analysis of clinical trials to evaluate the impact of WBV on physical function and quality of life outcomes in CKD patients. METHODS: A systematic search was performed on the PubMed, Embase, Web of Science, and Scopus databases from inception to March 2023 and updated in June 2023. The inclusion criteria comprised randomized controlled studies, quasi-experimental studies, and single-arm trials that evaluated the impact of WBV on physical function, encompassing cardiopulmonary fitness, muscle strength, mobility, and balance, in CKD patients. Adverse events that were included in the study reports were recorded. The pooled evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method. RESULTS: Nine studies were identified, of which seven were included in the meta-analysis. The results of the meta-analysis indicated a statistically significant improvement in upper (mean difference: 3.45 kg; 95% confidence interval 1.61 to 5.29) and lower (standardized mean difference: 0.34, 95% confidence interval 0.08 to 0.59) extremity muscle strength in patients with CKD who underwent WBV training compared to baseline (low-level evidence). Furthermore, WBV training favored improved cardiorespiratory fitness, mobility, and balance function, but no statistical difference was observed. The impact of WBV training on quality of life in patients with CKD requires further validation. Notably, only one adverse event (nausea) was reported in the included studies. CONCLUSIONS: WBV has demonstrated efficacy and feasibility in enhancing muscle strength among patients with CKD. However, further investigation is warranted to determine its potential for improving cardiorespiratory adaptations, mobility, balance function, and quality of life. Additionally, future research should prioritize comprehensive reporting of WBV protocols to establish an optimal training regimen for the CKD population.

Effects of intermittent hypoxia and whole-body vibration training on health-related outcomes in older adults.

BACKGROUND: Aging is associated with a health impairment and an increase of the vulnerability of the older people. Strength training under intermittent hypoxic conditions has been shown to have therapeutic effects on individual's health. AIMS: The aim of this study was to investigate the effects of a combined intermittent hypoxia (IH) and whole-body vibration (WBV) training program on health-related outcomes in older people. METHODS: A total of 60 adults (over the age of 65) voluntarily participated in an intervention that lasted 20 weeks (three 30-min sessions per week). The participants were divided into four experimental groups subjected to different environmental conditions (IH vs normoxia) and exercise (non-exercise vs WBV). Functional fitness, body composition, metabolic parameters, inflammatory biomarkers, and bone turnover were evaluated before and after the intervention. A multifactorial ANOVA with repeated measures was performed to explore differences within and between groups. RESULTS: The results showed that IH and WBV had a positive synergistic effect on inflammatory parameters (CRP and IL-10), bone formation biomarker (PINP), and body composition (muscle and bone mass). CONCLUSION: In conclusion, a combined IH and WVB training could be a useful tool to prevent the deterioration of health-related outcomes associated with aging. Clinical trial registration NCT04281264. https://clinicaltrials.gov/ .

Determinants of discomfort from combined exposure to noise and vibration in dumper operators of mining industry in India.

In the mining industry, dumper operators are exposed to combined noise and vibration, leading to discomfort. Dumpers are heavy earth-moving machines that are used for carrying bulky material in mining industries. Dumper operators are exposed to physical hazards such as vibration, noise, heat, and humidity, throughout their lifetime of work. Fifty-four dumper operators working in mines were selected for this study. Noise was measured as per the guidelines of the Directorate General Mining Safety, India, and whole-body vibration was measured as per the guidelines of ISO 2631-1::1997. Noise Pro DLX, Type 2 noise dosimeters were used for the measurement of personal noise exposure while SV-106 six channels vibration meters were used for whole body vibration (WBV) exposure measurement. Discomfort was calculated using the regression equation developed by Huang and Griffin (2014). The total discomfort level of mine operators was about 192. A predictive equation was derived by using a regression model to determine the contribution of individual variables causing discomfort. It was observed that for every unit increase in noise (LAeq), discomfort increased by 10.20 units, a one-unit increase in vibration (A (8)) led to a 51.7-unit increase in discomfort, while an increase of one unit of exposure time increased the discomfort level by 5.24 units.

Discomfort estimation for vertical whole-body vibration in the aircraft cabin considering the duration and static sitting comfort.

This paper investigated the discomfort caused by vertical whole-body vibration (WBV) over 20 minutes using data recorded at the front, middle, and rear seats of the passenger cabin in civil aviation during a cruising flight. Twenty-four subjects experienced each stimulus at 0.5 ms-2 r.m.s. and judged discomfort at various moments (i.e. 1/6, 5, 10, 15, and 20 min) using a category-ratio method. The difference in discomfort due to high-frequency vibration components vanished after 10 min. Based on Stevens' power law, a method is developed to estimate long-term vertical WBV discomfort by considering the static discomfort and an interaction coefficient between vibration and static discomfort as parameters. The proposed estimation method showed high accuracy with determination coefficients (R2) higher than 0.97 and good linearity with values of growth rates 0.95, 1, and 0.95 for the vertical WBV discomfort at the front, middle, and rear seat positions in the aircraft cabin.Practitioner summary: An estimation method for the discomfort caused by vertical WBV considering the duration and static sitting discomfort is developed. This method can provide accurate discomfort estimating for long-term vibration exposure, e.g. in civil aviation during a cruising flight, by introducing an 'interaction term' between static and dynamic discomfort.

Difference thresholds for primary and secondary ride of a vehicle on a 4-poster test rig.

Not only is it important to know how large the overall change in vibration should be for occupants to perceive an improvement in comfort, but also how large this change should be in specific frequency bands. Relative difference thresholds (RDT) of primary (0.5-4 Hz) and secondary (9-80 Hz) ride are estimated for 14 automotive engineers seated in a vehicle on a 4-poster test rig over two roads. Resulting stimuli differed in magnitude and spectral shape. The median RDTs estimated for primary and secondary ride were 16.68% and 13.82% on the smooth road, and 9.50% and 24.67% over the rough road. Statistically significant differences were found in the medians of the RDTs between (1) primary and secondary ride on the two roads and (2) the two roads for changes in the primary and secondary ride, suggesting that Weber's law does not hold.

Relative difference thresholds of primary and secondary ride are estimated that can be used to evaluate whether modifications to vehicle characteristics result in perceivable changes of vehicle vibration. Results suggest that Weber's law does not hold implying that relative difference thresholds should be used that closely match the stimuli characteristics.

Osteoporosis in children and adolescents: how to treat and monitor?

Osteoporosis is a condition of increased bone fragility associated with fractures. Apart from primary genetic osteoporotic conditions, secondary osteoporosis in children is being increasingly recognized. As a result, there is growing interest in its prevention and treatment. Important goals of care are to prevent fractures, increase bone mass and trabecular and cortical thickness, reshape vertebral fractures, prevent (or correct) skeletal deformities, and improve mobility, independence, and quality of life. Secondary pediatric osteoporosis is often of multifactorial origin since affected children frequently have more than one acquired factor that is detrimental to bone health. Typical conditions causing osteoporosis are leukemias, progressive muscle or neurological disorders, as well as chronic inflammatory conditions and their treatment. Management of children with osteoporosis involves a multidisciplinary team involving pediatric experts from different subspecialties. With regard to prevention and early intervention, it is important to provide optimal management of any underlying systemic conditions including avoidance, or dose-reduction, of osteotoxic medications. Basic supporting life-style measures, such as appropriate nutrition, including adequate calcium intake and vitamin D, and physical activity are recommended, where possible. When pediatric treatment criteria for osteoporosis are met, antiresorptive drugs constitute the first pharmacological line treatment. CONCLUSION: This clinical review focuses on the prevention, treatment, and follow-up of children with, or at risk of developing, osteoporosis and the transition from pediatric to adult care. WHAT IS KNOWN: • Osteoporosis and associated fractures can cause significant morbidity and reduce the quality of life. • The developing skeleton has huge potential for recovery and reshaping, thus early detection of fractures, assessment of recovery potential, and treatment of children with osteoporosis can prevent future fractures, deformities, and scoliosis, improve function and mobility, and reduce pain. WHAT IS NEW: • Osteoporosis in children and adolescents requires a multidisciplinary approach with a thorough assessment of recovery potential, and indication for therapy should be personalized. • Although bisphosphonates still represent the drug most commonly used to increase bone mass, improve mobility, and reduce pain and recurrence of fractures, new agents are being developed and could be beneficial in children with specific conditions.

Prevention of bone deterioration by whole-body vibration in a rat model of pre-type 2 diabetes.

OBJECTIVES: To examine effects of whole-body vibration (WBV) on bone properties in pre-type 2 diabetes mellitus (T2DM) rats. METHODS: Six-week-old male Hos:ZFDM-Lepr fa, fa/fa (DM) and Hos:ZFDM-Leprfa,fa/+ (CON; untreated non-DM) rats were used in the experiments. Half of DM rats were subjected to WBV (45 Hz, 0.5 g, 15 min/day, 5 days/week) for 8 weeks (WBV group), and the other half was not (DM group). RESULTS: Bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) parameters were worse in the DM and WBV groups compared with the CON group. Maximum load was significantly decreased in the DM group compared with the CON group, and the break point was significantly higher in the WBV group compared with the DM group. Serum levels of bone specific alkaline phosphatase were significantly lower in the WBV group compared with the CON group. Glycemic control was not worse in the WBV group compared with the DM group, but not the same levels as the CON group. CONCLUSIONS: These findings suggest that WBV can potentially delay the decrease in maximum load, although it does not prevent the deterioration of bone mass, TBMS, and CBG parameters.

Experimental Analysis of Passenger Comfort with Variable Preloaded Rear Springs on a Low-Cylinder Motorcycle.

The present study contains an experimental analysis of the vibratory response in a low-cylinder engine motorcycle at varying suspension preloads. Three different speed bumps of varying heights were used to subject the motorcycle to different vibrations. The analysis was carried out in three domains: time, frequency, and time-frequency. A triaxial accelerometer was used to measure the vibrations at the seat of the vehicle. The results indicated that the suspension system became more differentiated as the height of the bumps increased. However, for lower bumps, the action of the three spring preloads studied was quite similar. Quantitatively, only the higher bump showed a significant difference between the set preloads. The spectral distribution revealed that the frequency of interest was below 20 Hz for all the studied cases, which is in the same range of human body natural frequencies. The findings of this research can be utilized to enhance the design of low-cost motorcycles, thereby improving the safety and comfort of their drivers and passengers. This study constitutes a significant step towards developing an affordable system capable of gathering sufficient data to support the creation of evidence-based public health policies and propose new transport industry standards based on field measurements.

Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model.

Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have previously shown that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal and behavioral effects of chronic ethanol exposure. In this study, we employ a similar paradigm to assess the efficacy of WBV as a preventative measure of neuronal and behavioral effects of morphine withdrawal in a Wistar rat model. We demonstrate that concurrent administration of WBV at 80 Hz with morphine over a 5-day period significantly reduced adaptations in VTA GABA neuronal activity and NAc DA release and modulated expression of δ-opioid receptors (DORs) on NAc cholinergic interneurons (CINs) during withdrawal. We also observed a reduction in behavior typically associated with opioid withdrawal. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD) and should be examined translationally in humans.

Effects of Exercise and Omega-3-Supplemented, High-Protein Diet on Inflammatory Markers in Serum, on Gene Expression Levels in PBMC, and after Ex Vivo Whole-Blood LPS Stimulation in Old Adults.

Inflammaging is related to cell senescence and reflects an erratic immune system, which promotes age-associated diseases. Exercise and nutrition, particularly omega-3 fatty acids, are able to affect inflammation. Therefore, we examined the effects of an 8-week exercise and dietary intervention on the inflammatory response in community-dwelling old adults. All participants received weekly vibration and home-based resistance exercise. Furthermore, participants were randomized to either a control, high-protein (1.2-1.5 g/kg), or high-protein, omega-3-enriched (2.2 g/day) diet. Before and after treatment, inflammatory markers in fasting serum and after whole-blood ex vivo lipopolysaccharide (LPS) stimulation were assessed. Gene expression levels of inflammatory markers were quantified in peripheral blood mononuclear cells (PBMC). Sixty-one participants (age: 70.6 ± 4.7 years; 47% men) completed the study. According to generalized linear mixed models, a high-protein, omega-3-enriched diet decreased circulating anti-inflammatory interleukin (IL-) 10 and IL-1 receptor antagonist (IL-1RA). Sex-stratified analyses showed also significantly reduced pro-inflammatory markers in men with a high-protein, omega-3-enriched diet. Gene expression of IL-1RA was significantly reduced after both protein-enriched diets compared with controls. In comparison to a high-protein diet, exercise alone showed lower LPS-induced release of c-c motif chemokine ligand-2 (CCL-2), which tended to be more pronounced in men compared with women. Eight weeks of a high-protein, omega-3-enriched diet combined with exercise decreased circulating anti-inflammatory markers, and pro-inflammatory markers in men. A high-protein diet attenuated anti-inflammatory markers on gene expression level in PBMC. Exercise alone resulted in a lower pro-inflammatory response to LPS-exposure in whole-blood cultures.

Effects of the whole-body vibration direction on the cognitive response of standing subjects.

This study aims to investigate the effect of whole-body vibration along different axes on the response time (RT) of standing subjects during a customised psychomotor vigilance task (PVT). Twenty-five subjects were exposed to harmonic vibration with amplitude of 0.7 m/s2 RMS and frequencies between 1.5 Hz and 12.5 Hz. ANOVA was used to assess if the difference of RT with and without vibration had a statistical relevance. Results showed that the RT was statistically affected by the vibration only at frequencies below 2 Hz. The vibration at higher frequencies had a minor effect on the RT. The RTs during the vibration exposure was, on average, 15% higher than the RT post exposure. Practitioner summary: This study investigates the effects of whole-body vibration (WBV) along different axes on the response time (RT). We measured the RTs to a psychomotor vigilance task of 25 standing subject exposed to WBV. The cognitive response was statistically affected by the WBV and, on average RT have increased of 15%.

Whole-body vibration exposure in unfavourable seated postures: apparent mass and seat-to-head transmissibility measurements in the fore-and-aft, lateral, and vertical directions.

Mobile machinery operators are exposed to whole-body vibrations (WBV) and unfavourable postures which may lead to adverse effects on the spine. 14 subjects were exposed to WBV on a rigid seat without a backrest. They adopted nine different postures. Apparent mass MA(f) and seat-to-head transmissibility T(f) were measured in the horizontal (X), lateral (Y) and vertical (Z) directions. They were compared to the reference posture from the ISO 2631-1 standard. Head and thorax inclinations in the sagittal plane had significant effects. An increase in the main resonant frequency fr, together with a decrease in |MA(f)|max were observed in the Z direction. A second lower frequency peak also appeared (fr≈1 Hz for X, fr≈2.5 Hz for Z). fr increased in the X and Z directions for |T(f)|. |T(f)|max increased in the X direction. Head and thorax inclinations in the frontal and the horizontal planes had weak or non-significant effects.Practitioner summary: Mobile machinery operators are exposed to whole-body vibration and unfavourable body posture. Laboratory measurements of the apparent mass MA(f) and the seat-to-head transmissibility T(f) in the horizontal (X), lateral (Y) and vertical (Z) directions are presented for 9 postures relevant to the exposure at the driving position and to the effects of vibration on the spine.

Effects of vertical vibration on sitting comfort in civil aviation during the cruising flight.

This paper investigated the effects of vertical vibration on sitting comfort in civil aviation, with particular attention to high-frequency components (i.e. 30‒100 Hz). We generated 24 vibration stimuli at four positions (i.e. the co-pilot, front, middle, and rear seat positions) in the aircraft cabin, with magnitudes ranging from 0.05 to 2 ms-2 r.m.s. and durations of 10 s. Twenty-four subjects (12 males and 12 females) judged the vibration discomfort using a category-ratio method. We found a significant effect of high-frequency vibration on comfort: vibration stimuli at the middle and rear seats contained more energy at high frequencies and caused significantly greater discomfort than those at the co-pilot and the front seats. However, this effect became less significant with increasing magnitudes of vibration stimuli. The discomfort predicting models provided more accurate results by amplifying weighting factors for high-frequency vibration than those using standardised weightings (i.e. Wb and Wk weightings).Practitioner summary: The severity of high-frequency vibration for sitting comfort was usually underestimated. We investigated vibration discomfort at various seat positions in an aircraft cabin. Vibration at the middle and rear seats contained more high-frequency components and caused more discomfort. This work provided accurate predicting models of discomfort using the modified weighting.

Evaluation and prediction method of railway passenger long-term vibration comfort under complex operating conditions.

Vibration contributes large increases in railway passenger discomfort during long-term sitting. Discomfort caused by vibration may differ in different operation conditions. This paper conducted field measurements to investigate the interrelationships between the three. Participants completed a 240-min train journey with their whole-body vibration, subjective comfort ratings and train operating parameters being recorded. A large correlation was observed between the estimated vibration dose value and subjective comfort. The relationship that vibration magnitude significantly increases with increasing the train speed and tunnel density was also found and quantified. A vibration exposure limit of 2.08 m/s1.75 corresponding to the boundary between subjective ratings of comfortable and discomfortable was obtained. Based on the exposure limit and the quantified relationship, a vibration comfort prediction method that can calculate the passenger's maximum tolerance time under a given operation condition was proposed and may help in determining the optimal operating speed and tunnels distribution to alleviate vibration discomfort. Practitioner summary: Similar to the guide to effect of vibration on health in current standard, a vibration exposure limit regarding comfort was provided for reference when assessing long-term vibration comfort. Meanwhile, a prediction method was proposed for determining the best train operating speed and tunnels distribution, thereby alleviating railway passengers' vibration discomfort.

Equivalent magnitude-dependent discomfort under vertical vibration up to 100 Hz.

The effect of vibration magnitude on frequency-dependence of discomfort of human body is always overlooked with respect to the comfort equivalence contours, particularly for high-magnitude vibration in wideband frequency. In this study, the magnitude effect of vertical vibration on discomfort of human body is investigated experimentally. Nineteen male subjects are involved in the jury test of vibration discomfort in the vertical direction with 2-5 m/s2 in magnitude up to 100 Hz. It is shown that the growth rate of discomfort may exceed 1 due to the high-magnitude vibration employed. In this condition that the rate varies around 1, the Stevens' power law is not capable to properly represent the relationship between the subjective discomfort and the vibration magnitude. It means the equivalent comfort contours are not only dependent on the frequency range but also related to the vibration magnitude. Frequency weightings of vibration discomfort are influenced by the excitation magnitude. Practitioner summary: The occupant comfort to vertical whole-body vibration is affected by vibration magnitude. This study provides the effect of vibration magnitude on frequency-dependence of discomfort to whole-body vibration. It is suggested to propose variable frequency weightings for vibration discomfort evaluation under different magnitudes to achieve better comfort design.

A state-of-the-art review on biomechanical models and biodynamic responses.

Biomechanical models are mathematical representations of human structure. These models are used to analyse joint and injury mechanics and design of prosthetic devices for human body under various conditions. Biomechanical model development involves the integration of knowledge from various fields, including mechanics, biology, physiology, and mathematics. Biomechanical models have become more significant in the healthcare sector as researchers strive to offer better medical supplies and ride comfort. It has uses in automobile and sports science as well, to create human dummies for accident and segmental vibration transmissibility study, improve training routines, and prevent injuries. These biomechanical models might be anything from straightforward lumped parameter models to intricate multi-body models. The virtues, weaknesses, and contemporary uses of lumped parameter modelling and multi body modelling in biomechanical modelling are discussed in this article. Subsequently, emphasised the recent modelling improvements and explored the future direction of biomechanical modelling. Researchers and professionals who wish to apply biomechanical models to comprehend human movement and enhance performance may find this review to be helpful.

Our understanding of how the human body functions, moves, and responds to various situations has greatly improved as a result of the current review. The models play a critical role in the simulation and quantification of interactions between anatomical structures, tissues, and external forces, providing essential information on mobility, function, and damage mechanisms.

Finite element modelling and biodynamic response prediction of the seated human body exposed to whole-body vibration.

Biodynamic modelling of seat-occupant systems can assist in seat comfort design. A finite element (FE) model of the seated human body, including detailed modelling of the lumbar spine, was established to reflect the human response to vibration and biodynamic response of the lumbar spine under whole-body vibration (WBV). The lumbar spine model was established and validated against the in-vitro results and calculated data. The posture of the lumbar spine was adjusted according to the radiological research results, and the adjusted model was combined to establish a FE model of the seated human body. The present seated human model with backrest inclination angles of 10, 20, and 30°, validated by comparing the measured apparent mass and seat-to-lumbar spine transmissibility, was used to calculate the biodynamic response of the lumbar spine with three inclined backrests under WBV. The results showed that the model could characterise the apparent mass, seat-to-lumbar spine transmissibility, and the biodynamic response of the lumbar spine. Practitioner summary: Biodynamic models can represent dynamic characteristics of the human body exposed to vibration and assist in seat comfort design. The three-dimensional FE model of the human body can be used to explore the human response to vibration and the biodynamic response of the lumbar spine under WBV.