Membranes are functionalized by a proteolipid code.

Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly of zones such as receptor clusters, protein-coated pits, lamellipodia, cell junctions, and membrane fusion sites is explained to occur through a protein-lipid code. This challenges the theory that lipids sort proteins after forming stable membrane subregions independently of proteins.

Variations in orientation relationships between rutile inclusions and garnet host relate to magmatic growth zoning.

Rutile inclusions in almandine-spessartine garnet from a peraluminous pegmatoid from the Moldanubian zone (Bohemian Massif, AT) show distinct changes in aspect ratio, shape preferred orientations (SPO) and crystallographic orientation relationships (COR) along the transition between microstructurally different growth zones in the garnet core and rim. For identification of the COR characteristics we pool specific CORs based on their common axial relationship into three COR groups: Group 103R/111G, Group 001R/111G and Group 001R/100G. The rutile inclusions in the garnet core domains are elongated along the four Grt ⟨ 111 ⟩ directions and are dominated by COR Group 103R/111G. The garnet rim zone additionally contains rutile needles elongated along Grt ⟨ 100 ⟩ . Here, Group 001R/111G and 001R/100G are more abundant than in the garnet core. Needle-shaped rutile in the rim shows a systematic correlation between SPOs and CORs as needles elongated parallel to Grt ⟨ 111 ⟩ are dominated by Group 103R/111G and 001R/111G, whereas those needles elongated parallel to Grt ⟨ 100 ⟩ exclusively pertain to CORs of 001R/100G. Furthermore, the frequency of each particular SPO in the garnet rim clearly depends on the local growth direction of the particular Grt{112} sector. Facet-specific variations in rutile SPO frequencies in different sectors and growth zones of garnet were observed even between equivalent directions, indicating that the microstructures and textures of rutile inclusions reflect varying parameters of garnet growth. The characteristic differences in COR groups of different garnet growth zones are referred to compositional changes in the bulk melt or compositional boundary layer, associated with magmatic fractional crystallisation. Supplementary Information: The online version contains supplementary material available at 10.1007/s00410-024-02146-9.

Enhancing traumatic brain injury emergency care: the impact of grading and zoning nursing management.

OBJECTIVE: This research aimed to evaluate the impact of grading and zoning nursing management on traumatic brain injury (TBI) patients' emergency treatment outcomes. METHODS: This randomized controlled trial included 200 TBI patients. They were treated with a conventional care (control group, n = 100) and a novel grading and zoning approach (study group, n = 100), respectively. This innovative model organized care into levels based on urgency and complexity, facilitating targeted medical response and resource allocation. Key metrics compared included demographic profiles, consultation efficiency (time metrics and emergency treatment rates), physiological parameters (HR, RR, MAP, SpO2, RBS), and patient outcomes (hospital and ICU stays, complication rates, and emergency outcomes). RESULTS: The study group demonstrated significantly improved consultation efficiency, with reduced times for physician visits, examinations, emergency stays, and specialist referrals (all p < 0.001), alongside a higher emergency treatment rate (93% vs. 79%, p = 0.004), notably better physiological stability, improved HR, RR, MAP, SpO2 and RBS (p < 0.001), shorter hospital and ICU stays, fewer complications, and superior emergency outcomes. CONCLUSION: Grading and zoning nursing management substantially enhances TBI patients' emergency care efficiency and clinical outcomes, suggesting a viable model for improving emergency treatment protocols.

Spatiotemporal variability in human thermal comfort perception in open-air spaces: application to the state of Minas Gerais, Brazil.

The objective of this study was to propose bioclimatic zoning to classify human thermal comfort and discomfort in the state of Minas Gerais, Brazil; both historical and future scenarios are considered. Thus, historical series (1961 to 2017) of the effective temperature index as a function of the wind (ETW) were obtained as a function of the monthly average values of the minimum, mean, and maximum dry-bulb air temperatures (tdb,min, tdb,mean, and tdb,max, respectively), in addition to the mean relative humidity ([Formula: see text], %) and mean wind speed ([Formula: see text], m s -1). The data were obtained from 34 weather stations and subjected to trend analysis by using the nonparametric Mann-Kendall test, thus enabling the simulation of future scenarios (for 2028 and 2038). Then, to define the thermal ranges of the bioclimatic zoning, maps of ETWmin, ETWmean, and ETWmax were created from geostatistical analysis. Overall, the results show warming trends for the upcoming years in Minas Gerais municipalities. All climatic seasons showed an increase in the frequency of new classifications in the upper adjacent classes, which indicates climate warming. Therefore, when considering future scenarios for the autumn and winter seasons, attention should be given to changes in predicted thermal sensation, especially in the Central Minas Gerais, Belo Horizonte Metropolitan, South/Southwest Minas, Campo das Vertentes, and Zona da Mata.

County-level carbon compensation zoning based on China's major function-oriented zones.

Large but overlooked carbon inequalities among counties in China matter for the design of mitigation strategies. Here, we investigated the spatial heterogeneity of carbon inequality across 2236 county-level units nationwide from 2000 to 2020, refining carbon compensation zone types based on land functional zoning and estimating their carbon compensation values using a modified compensation model. Our results showed that China's carbon inequality consistently exceeded the cautionary threshold of 0.4 on the Gini coefficient. Significant spatial variations in carbon intensity were observed, notably concentrated in the North China Plain and Yangtze River Delta, indicating a pronounced core-periphery structure. The nonlinear relationships among carbon emission pressure (CEP), land use intensity (LUI), economy contributive coefficient (ECC), and ecological support coefficient (ESC) were identified. CEP and ECC posed initial increases followed by decreases with LUI, while ESC decreased with increasing LUI. The inverted U-curve between ECC and CEP suggested that most county-level cities have yet to reach the decoupling tipping point. Based on spatial comparative advantage, we identified 625 payment zones, 666 equilibrium zones, and 945 recipient zones, culminating in nine types of carbon compensation zones aligned with land functional objectives. Our study provides a new county-level carbon compensation zoning approach that can achieve carbon equity.

Assessing the impact of three biosphere reserves on the conservation of coastal ecosystems.

Biosphere Reserves (BR) manage large territories with diverse natural covers and land uses to preserve biodiversity, promote local development and preserve ecosystems. This study evaluated how their zoning (buffer and core) and policy timeframes (decree period, management plan period, and land planning period) influence four landscape management outcomes: deforestation, natural cover recovery, and anthropic and natural permanence. For three Mexican BR case studies, land use and cover transitions were calculated and compared to contrafactual sites. Observed rates of land cover change were marginal within all three BR zoning and across their policy timeframe (<0.02 % change rate), suggesting that BR effectively promote the permanence of both natural and anthropic covers. Nevertheless, the predicted probability of uncommon deforestation and recovery outcomes at local levels showed that the effect of a BR over its regulated landscape is not spatiotemporally static, contrasting the effect of individual allocation vs a group or network. Poverty, land tenure, agriculture aptitude and distance to markets adds to this dynamic and is modelled and discussed. This study shows that BR zoning schemes and its regulatory sequence influence the rates of land cover change and the predicted probability of landscape management outcomes across space and time.

Ecological restoration zoning of territorial space in China: An ecosystem health perspective.

Rapid urbanization and high-intensity socio-economic activities in China have caused severe ecological problems. Implementing ecological restoration in China has become an inevitable way to restore the ecosystem. Ecosystem health is crucial for evaluating ecological conditions and trends, but comprehensive national studies that use quantitative ecosystem health assessments to guide specific ecological restoration are lacking. This study constructs the Vigor-Organization-Resilience-Services (VORS) model to evaluate the ecosystem health level of China during 2000-2020. Then, through the natural breakpoint and intelligent clustering correction, we carried out the ecological restoration zoning and proposed corresponding measures. The results show that China's overall ecosystem health declined from 2000 to 2020, and ecological restoration is imminent. The spatial pattern of ecosystem health is generally favorable in the south and usually poor in the north. China protects poor ecosystems' health well but needs more for better ones. To combat this degradation, we propose a zoning strategy that classifies the landscape into five categories: Ecosystem Conservation Areas (3.47%), focusing on biodiversity preservation; Ecosystem Enhancement Areas (10.53%), aiming at increasing ecological resilience; Ecosystem Buffer Zones (23.04%), intending to mitigate human impacts; Ecosystem Correction Zones (33.79%), targeting at restoring degraded ecosystems; and Ecosystem Reshaping Zones (29.17%), designing to revitalize ecological functions. The ecological restoration zoning in China proposed in this study, combined with appropriate and practical restoration tools, will help mitigate ecological problems and improve stability and ecosystem health.

Enhancing dynamic flood risk assessment and zoning using a coupled hydrological-hydrodynamic model and spatiotemporal information weighting method.

Climate change and intensified human activities are exacerbating the frequency and severity of extreme precipitation events, necessitating more precise and timely flood risk assessments. Traditional models often fail to dynamically and accurately assess flood risks due to their static nature and limited handling of spatiotemporal variations. This study confronts these challenges head-on by developing a novel coupled hydrological-hydrodynamic model integrated with a Block-wise use of the TOPMODEL (BTOP) and the Rainfall-Runoff-Inundation (RRI) model. This integrated approach enables the rapid acquisition of high-precision flood inundation simulation results across large-scale basins, addressing a significant gap in dynamic flood risk assessment and zoning. A critical original achievement of this research lies in developing and implementing a comprehensive vertical-horizontal combined weighting method that incorporates spatiotemporal information for dynamic evaluation indicators, significantly enhancing the accuracy and rationality of flood risk assessments. This innovative method successfully addresses the challenges posed by objective and subjective weighting methods, presenting a balanced and robust framework for flood risk evaluation. The findings from the Min River Basin in China, as a case study, demonstrate the effectiveness of the BTOP-RRI model in capturing the complex variations in runoff and the detailed simulations of flood processes. The model accurately identifies the timing of these peaks, offering insights into the dynamic evolution of flood risks and providing a more precise and timely assessment tool for policymakers and disaster management authorities. The flood risk assessment results demonstrate good consistency with the actual regional conditions. In particular, high-risk areas exhibit distinct characteristics along the river channel, with the distribution area significantly increasing with a sudden surge in runoff. Intense precipitation events expand areas classified as moderate and high risk, gradually shrinking as precipitation levels decrease. This study significantly advances flood risk assessment methodologies by integrating cutting-edge modeling techniques with comprehensive weighting strategies. This is essential for improving the scientific foundation and decision-making processes in regional flood control efforts.

Management zones in transboundary aquifers: A review of delineation methods under a new framework of cross-border groundwater impacts.

Attention on the use of transboundary aquifers (TBAs) and their cross-border impacts is growing as countries become increasingly concerned about their long-term water security. Cross-border impacts, in groundwater quality and quantity, tend to concentrate in specific parts of TBAs, as they largely depend on the transboundary flow dynamics where anthropogenic actions operate. Thus, there is a growing consensus that strategies intended to prevent or mitigate such impacts should be implemented in strategic zones rather than in the whole TBA. These transboundary groundwater management zones (TGMZs) are relatively recent but have become a prominent topic in TBA management. However, until now, limited effort has been put into exploring the concept of TGMZs and the methods for their delineation. This research aims to fill these gaps and provide a basis for the delineation of TGMZs, thus helping neighbouring countries meet international responsibilities regarding the right to use and enjoy groundwater in TBAs. By reviewing academic and grey literature accessible from public sources, we present an overview of the concept and terminology of TGMZs, the approaches proposed for their delineation, and current operating examples. Additionally, we build a conceptual framework for assessing cross-border groundwater impacts by identifying their typologies and causal factors. We then apply our framework to evaluate and compare three reported methods which identify and delineate TGMZs from distinct perspectives, thereby gaining insights into their principles, performances, and limitations. Finally, we provide recommendations for further research towards optimising methods for delineating TGMZs.

Does settlement land expansion necessarily induce the decrease of cultivated land? Differences in national scale and local counties of China.

With the extensive industrialization and urbanization taking place in China during the recent decades, land use throughout the country has experienced profound changes influenced not only by the demand for population growth and living standard improvement but also by the constraints of series of land use policies. However, whether the conflict between the expansion of settlement land (SL) and the loss of cultivated land (CL) have been resolved at the national scale or transferred between the local regions remains unclear. Based on yearly ESA CCI land use and land cover products from 1992 to 2020, the long-term trends of quantity and spatial pattern of SL expansion and CL change in China from national and local views were investigated using trend statistic methods, and finally a comprehensive zoning framework was proposed to recognize the trade-off and synergies relationships between SL expansion and CL change. There are a continuous expansion of SL with global linear trends showing three breakpoints in 2000, 2005, and 2012, and a fluctuation decline of CL presented with four breakpoints in 1997, 2002, 2006, and 2013. Aggregation and dispersion tendencies with linear characteristics of SL expansion and CL change were found with breakpoints in 2001, 2008, 2012, and 2016 and breakpoints in 2001 and 2010, respectively. A spotty spatial pattern of SL was shown spatially coincident with urban agglomerations in China while the planar continuous characteristic was found for CL. Local counties were classified into five tradeoff and synergies zones (TSZs), where general synergies (G-S) and decoupling (D) of SL expansion and CL change were rare cases and the different change in quantity and trend of SL expansion and CL change in local counties was concealed by the national trend. A few scattered counties were belonging to G-S and D TSZs, while most of the counties in the central-east and western China were in General-Tradeoff (G-T) and Superior-Tradeoff (S-T) TSZs. Counties in south and north China with higher percentages of CL were more prevalent in Superior-Synergy (S-S) TSZ. Our findings explicated the complex relationships between SL expansion and CL change of China at the national scale and in local counties, which pointed out the differences of unified land use management activities across scales and could provide insights for future policy-making and management measures of land use to both ensure the national food security and promote regional sustainable development more synchronously.

Linking the assessment of ecological engineering construction with zoning management in the typical agro-pastoral area of China: A perspective from quantity, quality and function.

Combatting land damage has become a global priority, and China has adopted a series of ecological engineering measures, especially in the agro-pastoral area with fragile ecological environment. The effectiveness of ecological engineering construction (EEC), from a comprehensive recognition encompassing its quality, quantity, and function, has remained largely unknown. To this end, Zhangbei County, a typical agro-pastoral ecotone of northern China, was chosen as our focal area. After summarizing the timelines, aims and results of the EEC during various periods in Zhangbei, the linear spectral mixture analysis was employed to process Landsat 5 TM images in 2000 and 2010, as well as Landsat 8 OLI images in 2020. Then, a comprehensive evaluation framework of EEC was established from the perspective of "quantity-quality-function", and the ecological effectiveness of EEC was evaluated from 2000 to 2020 in Zhangbei. Results revealed that EEC played a critical role in enhancing quantity, quality and function, in spite of that, there were still numerous regions showing varying degrees of degradation in terms of these aspects. Then, by extending the three-dimensional cube as the theoretical basis for the zoning management of EEC, we merged four zones according to the space matching relationship among quantity, quality and function of EEC, namely, Ecological conservation area, Ecological improvement area, Ecological restoration area and Ecological remodeling zone. More targeted ecological measures were required for specific matching relationship among quantity, quality and function of EEC. This study is expected to present an empirical case for assessing the ecological effectiveness of EEC in areas or countries with similar restoration demand and support regional management.

Optimizing zoning for ecological management in alpine region by combining ecosystem service supply and demand with ecosystem resilience.

In order to enhance ecosystem stability and promote sustainable regional ecological, social, and economic development, it is crucial to explore the coupling relationship between ecosystem service supply and demand and the resilience of ecosystem, so as to propose scientific ecological management zones and strategies. Taking the vulnerable alpine ecosystem in Gannan Tibetan Autonomous Prefecture (Gannan Prefecture) as the study area, this paper comprehensively utilized multi-source data, grid analysis, ecosystem service supply and demand estimation model, and coupled coordination model to analyze the spatio-temporal differentiation and coordination pattern of ecosystem service supply and demand in the study area from 2000 to 2020. With the assistance of the Analytic Hierarchy Process (AHP), the ecosystem resilience index system was constructed to evaluate the regional ecological resilience. The results reveal the following: (1) In the past 20 years, the ecosystem service supply and resilience in Gannan Prefecture showed a fluctuating upward trend, and the demand continued to grow steadily. Their spatial differentiation were obvious, but the pattern remained stable. (2) There was a moderate incoordination indicated by the average coordination degree of the supply and demand coupling of ecosystem services, which rangeed between 0.3 and 0.4. (3) Gannan Prefecture was split into three ecological management zones, considering the spatial distribution of ecosystem service supply and demand, as well as resilience. Through system function monitoring and other measures, the ecological conservation zone will rely on its high resilience to support the restoration and self-sufficiency of the system, ensuring the stability and well-being of the ecosystem. The primary objectives of general protected zone includes environmental preservation, strict regulations, and the prevention of human intervention. To enhance their ecological background, key restoration zone must intensify the implementation of ecological restoration initiatives. To address the needs of the locals, strategies such as ecological compensation, optimizing the land use structure, and fostering the growth of environmentally friendly companies can be implemented simultaneously.

Lessons Learned from a Citywide Abandoned Housing Experiment.

Problem research strategy and findings: The negative impact of vacant and abandoned housing in city neighborhoods is extreme, affecting health and quality of life, promoting violence, and leading to further abandonment. One approach to addressing abandoned housing is to intervene with low-cost interventions that provide a visual sense of ownership. We tested whether a low-cost remediation of abandoned and vacant houses or a trash cleanup intervention would make a noticeable difference in the levels of nearby disrepair, disorder, and public safety. The abandoned housing remediation and trash cleanup interventions were a test of compliance with municipal ordinances. We used an experimental design to test the causal effects of the ordinances, and because the scale of abandonment was too large to provide treatment to all abandoned houses in the city. We used systematic social observation methods to rate changes in disrepair, disorder, and litter at housing sites and on the city blocks they were located, and police reported data on gun violence and illegal substance uses. Our experimental design allowed us to see if observed disrepair, disorder, and public safety improved after working windows and doors were installed on abandoned houses compared with a trash cleanup around properties or a no-intervention control condition. Our results showed significant changes in observed disrepair, disorder, and gun violence and illustrate the benefits of experimental evaluations of place-based changes to the built environment. Takeaway for practice: Improving compliance with ordinances to remediate abandoned housing can make a noticeable difference in disrepair in neighborhoods and contribute improved public safety. We illustrate how planners can use field experiments in partnership with city agencies, nonprofit community groups, and local universities to discover novel approaches to advance place-based changes to the built environment that can help economically disadvantaged communities abate problems of physical disorder.

Environmental vulnerability applied to the territorial planning of a tropical semiarid basin.

Tropical semiarid regions are naturally prone to environmental damage. Human activity can worsen this situation. To understand how human actions affect the ecosystem, plan land use effectively, and establish targeted management practices, assessing environmental vulnerability is crucial. This study focuses on a sub-basin receiving water transfers from the São Francisco River in Brazil's semiarid region. Here, we map and evaluate how land use and occupation alter natural vulnerability. We also propose zoning strategies to support water resource management and implement sustainable development policies in the region. To achieve this, we conducted an integrated analysis of physical factors (soil types, geology, climate, vegetation, and landforms) and spatial land-use data using geographic information systems (GIS) and map algebra techniques. Map algebra allowed us to combine these various datasets within the GIS environment, enabling the creation of maps that synthesize both natural and environmental vulnerability across the study area. Following analysis of these vulnerability maps, our findings reveal a high level of vulnerability. The areas with high to very high degrees of natural vulnerability coincide with the places that have high slopes, high altitudes, Lithic Neosols, and thick vegetation. Furthermore, the interaction between environmental factors and human activity exacerbates vulnerability. Based on the environmental vulnerability assessment, we defined four environmental management zones. These zones require distinct protection measures and management approaches. As a method to potentially improve the basin's vulnerability scenario, soil conservation measures are recommended. This approach is highly relevant for managing land in tropical semiarid regions and, with adaptations to specific regional factors, can be applied globally.

Integrated assessment and prediction of ecological security in typical ecologically fragile areas.

In order to safeguard and restore ecological security in ecologically fragile regions, a regionally appropriate land use structure and ecological security pattern should be constructed. Previous ecological security research models for ecologically fragile areas are relatively homogenous, and it is necessary to establish a multi-modeling framework to consider integrated ecological issues. This study proposes a coupled "PLUS-ESI-Circuit Theory" framework for multi-scenario ecological security assessment of the Ningxia Hui Autonomous Region (NHAR). Firstly, the PLUS model was used to complete the simulation of four future development scenarios. Secondly, a new ecological security index (ESI) is constructed by synthesizing ecological service function, ecological health, and ecological risk. Finally, the Circuit Theory is applied to construct the ecological security pattern under multiple scenarios, and the optimization strategy of ecological security zoning is proposed. The results show that (1) from 2000 to 2030, the NHAR has about 80% of grassland and farmland. The built-up area is consistently growing. (2) Between 2000 and 2030, high ecological security areas are primarily located in Helan Mountain, Liupan Mountain, and the central part of NHAR, while the low ecological security areas are dominated by Shapotou District and Yinchuan City. (3) After 2010, the aggregation of high-security areas decreases, and the fragmentation of patches is obvious. Landscape fragmentation would increase under the economic development (ED) scenario and would be somewhat ameliorated by the ecological protection (EP) and balanced development (BD) scenarios. (4) The number of sources increases but the area decreases from 2000 to 2020. The quantity of ecological elements is on the rise. Ecological restoration and protection of this part of the country will improve its ecological security.

Multi-criteria GIS-based land suitability analysis for rice cultivation: a case study in Guilan Province, Iran.

Ensuring food security and sustainable resource management has become a paramount global concern, prompting significant attention to land suitability analysis for enhancing agricultural production. In this study, an AHP-weighted overlay method was employed to delineate rice cultivation suitability in Guilan province, Iran, a central hub for rice production. Sixteen climatic, topographic, and soil variables were integrated, and individual maps were reclassified to align with the specific requisites for rice production. The results revealed three suitability classes: including 'very suitable,' 'suitable,' and 'moderately suitable', covering 91%, 6%, and 3% of the land, respectively. Soil attributes, particularly organic matter, significantly influenced suitability (weight value of 0.745), with topographic and soil factors outweighing climate in assessment. While salinity is generally absent, organic matter deficiency affects 44% of the land. Phosphorus imbalances are prevalent, with potassium toxicity observed in 10%. Microelement deficiencies, especially in iron and zinc, are noted. Additionally, the results indicated that topographic and soil attributes played a more significant role than climate-related factors in assessing land suitability for rice cultivation within the study area. This research provides a comprehensive spatial analysis of all variables in the study region, shedding light on the complexities of land suitability for rice cultivation. These findings contribute to the understanding of agricultural sustainability and resource management strategies in the context of food security.

The Race to Exclude: Residential Growth Controls in California Cities, 1970-1992.

Local regulations that restrict residential growth are a key driver of California's affordable housing crisis. Scholars have argued these growth controls were implemented in the late 20th century by cities intending to exclude Black households. However, growth controls may also have plausibly been driven by a desire to exclude growing Hispanic, Asian, and foreign-born populations; by increased concern about the negative environmental consequences of population growth; or by homeowners' or cities' fiscal motivations. I jointly test these competing explanations using time-varying data on the adoption of a variety of residential growth controls covering California cities from 1970-1992. I find that, all else equal, cities with a lower share of Black residents-both in absolute terms, and relative to their metropolitan area-were more likely to pass residential growth controls. I also find some evidence that growth controls were more likely to be passed in areas experiencing greater Black population growth and in cities more supportive of White-Black segregation. Finally, I find strong evidence that, net of other factors, cities in areas more supportive of policies to protect the environment were more likely to pass residential growth controls.

Pedestrian-oriented zoning moderates the relationship between racialized economic segregation and active travel to work, United States.

OBJECTIVE: Pedestrian-oriented zoning, including zoning code reforms (ZCR), may be especially beneficial to racially and economically segregated communities, which may lack built environment features that support physical activity. This study examined associations between racialized economic segregation, measured by quintiles of the Index of Concentration at the Extremes, and public transit (PTW) and active travel (ATW) to work, and whether associations were moderated by pedestrian-oriented zoning provisions and ZCR, respectively. METHODS: Zoning codes effective as of 2010 representing 3914 US municipalities (45.45% of US population) were evaluated for the presence of ZCR and eight pedestrian-oriented zoning provisions. These data were linked with American Community Survey 2013-2017 and NAVTEQ 2013 data on the outcomes and relevant covariates. Fractional logit regressions were computed with standard errors clustered on county. RESULTS: Workers from more deprived quintiles were less likely to engage in PTW and ATW (OR = 0.22-0.55, p < 0.01), and tests revealed moderation by zoning (p < 0.05). ZCR was positively associated with PTW for the three most deprived quintiles (OR = 1.53-2.38, p < 0.01), and with ATW for the two most deprived quintiles (OR = 1.42-1.69, p < 0.01) and the second most privileged quintile (OR = 1.26, p < 0.05). In the most privileged quintile, the zoning scale score was negatively associated with PTW (OR = 0.91, p < 0.001) and ATW (OR = 0.94, p < 0.01). However, in the most deprived quintiles, the zoning scale score was positively associated with PTW (Q2: OR = 1.13, p < 0.01) and ATW (Q1-Q2: OR = 1.07-1.09, p < 0.05). CONCLUSIONS: Pedestrian-oriented zoning can provide opportunities for ATW in the most deprived communities. Work is needed to explore zoning policy implementation in those communities.

Assessing the transmissibility of epidemics involving epidemic zoning.

BACKGROUND: Epidemic zoning is an important option in a series of measures for the prevention and control of infectious diseases. We aim to accurately assess the disease transmission process by considering the epidemic zoning, and we take two epidemics with distinct outbreak sizes as an example, i.e., the Xi'an epidemic in late 2021 and the Shanghai epidemic in early 2022. METHODS: For the two epidemics, the total cases were clearly distinguished by their reporting zone and the Bernoulli counting process was used to describe whether one infected case in society would be reported in control zones or not. Assuming the imperfect or perfect isolation policy in control zones, the transmission processes are respectively simulated by the adjusted renewal equation with case importation, which can be derived on the basis of the Bellman-Harris branching theory. The likelihood function containing unknown parameters is then constructed by assuming the daily number of new cases reported in control zones follows a Poisson distribution. All the unknown parameters were obtained by the maximum likelihood estimation. RESULTS: For both epidemics, the internal infections characterized by subcritical transmission within the control zones were verified, and the median control reproduction numbers were estimated as 0.403 (95% confidence interval (CI): 0.352, 0.459) in Xi'an epidemic and 0.727 (95% CI: 0.724, 0.730) in Shanghai epidemic, respectively. In addition, although the detection rate of social cases quickly increased to 100% during the decline period of daily new cases until the end of the epidemic, the detection rate in Xi'an was significantly higher than that in Shanghai in the previous period. CONCLUSIONS: The comparative analysis of the two epidemics with different consequences highlights the role of the higher detection rate of social cases since the beginning of the epidemic and the reduced transmission risk in control zones throughout the outbreak. Strengthening the detection of social infection and strictly implementing the isolation policy are of great significance to avoid a larger-scale epidemic.

Trace element partitioning in basaltic systems as a function of oxygen fugacity.

Along with temperature, pressure and melt chemistry, magmatic oxygen fugacity (fO2) has an important influence on liquid and solid differentiation trends and melt structure. To explore the effect of redox conditions on mineral stability and mineral-melt partitioning in basaltic systems we performed equilibrium, one-atmosphere experiments on a picrite at 1200-1110 °C with fO2 ranging from NNO-4 log units to air. Clinopyroxene crystallizes from 1180 °C to near-solidus, along with plagioclase, olivine and spinel. Olivine Mg# increases with increasing fO2, eventually reacting to pigeonite. Spinel is absent under strongly reducing conditions. Mineral-melt partition coefficients (D) of redox-sensitive elements (Cr, Eu, V, Fe) vary systematically with fO2 and, in some cases, temperature (e.g. DCr in clinopyroxene). Clinopyroxene sector zoning is common; sectors along a- and b-axes have higher AlIV, AlVI, Cr and Ti and lower Mg than c-axis sectors. In terms of coupled substitutions, clinopyroxene CaTs (MgSi = AlVIAlIV) prevails under oxidized conditions (≥ NNO), where Fe3+ balances the charge, but is limited under reduced conditions. Overall, AlIV is maximised under high temperature, oxidizing conditions and in slowly grown (a-b) sectors. High AlIV facilitates incorporation of REE (REEAlIV = CaSi), but DREE (except DEu) show no systematic dependence on fO2 across the experimental suite. In sector zoned clinopyroxenes enrichment in REE3+ in Al-rich sectors is quantitatively consistent with the greater availability of suitably-charged M2 lattice sites and the electrostatic energy penalty required to insert REE3+ onto unsuitably-charged M2 sites. By combining our experimental results with published data, we explore the potential for trace element oxybarometry. We show that olivine-melt DV, clinopyroxene-melt DV/DSc and plagioclase-melt DEu/DSr all have potential as oxybarometers and we present expressions for these as a function of fO2 relative to NNO. The crystal chemical sensitivity of heterovalent cation incorporation into clinopyroxene and the melt compositional sensitivity of the Eu2+-Eu3+ redox potential limit the use of clinopyroxene-melt and plagioclase-melt, however, olivine-melt DV affords considerable precision and accuracy as an oxybarometer that is independent of temperature, and crystal and melt composition. Variation of DV and DV/DSc with fO2 for olivine and clinopyroxene contains information on redox speciation of V in coexisting melt. By comparing the redox speciation constraints from partitioning to data from Fe-free synthetic systems and XANES spectroscopy of quenched glasses, we show that homogenous equilibria involving Fe and V species modify V speciation on quench, leading to a net overall reduction in the average vanadium valence. Mineral-melt partitioning of polyvalent species can be a useful probe of redox speciation in Fe-bearing systems that is unaffected by quench effects. Supplementary Information: The online version contains supplementary material available at 10.1007/s00410-023-02069-x.