RESUMO
BACKGROUND: Gordonia polyisoprenivorans is a ubiquitous aerobic actinomycetes bacterium that rarely cause infections in humans. Here, we report a case of G. polyisoprenivorans catheter-related bacteremia in an AIDS patient. CASE PRESENTATION: A 37-year-old man with a past medical history of AIDS-related lymphoma suffered bacteremia caused by a Gram-positive corynebacterium. The strain was identified as a Gordonia species by matrix-assisted laser desorption ionization-time of flight mass spectrometry and confirmed to G. polyisoprenivorans by 16S rRNA combined with gyrB gene sequencing analyses. The patient was treated with imipenem and had a good outcome. CONCLUSIONS: The findings from our case and previously reported cases indicate that malignant hematologic disease, immunosuppression, and indwelling catheter heighten the risk for G. polyisoprenivorans infection. Molecular methods should be employed for proper identification of G. polyisoprenivorans to the species level.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Infecções por Actinomycetales/microbiologia , Bacteriemia/microbiologia , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Infecções por Actinomycetales/tratamento farmacológico , Adulto , Bacteriemia/tratamento farmacológico , Infecções Relacionadas a Cateter/tratamento farmacológico , Infecções Relacionadas a Cateter/microbiologia , Cateteres de Demora , Bactéria Gordonia/genética , Bactéria Gordonia/patogenicidade , Humanos , Masculino , RNA Ribossômico 16S/genéticaRESUMO
This review about the genus Gordonia provides a current overview of recent research on a young genus that was introduced in the year 1997 ( Stackebrandt et al., 1997 ). This emerging genus has attracted increasing environmental, industrial, biotechnological and medical interest during the last few years, in particular due to the capabilities of its members to degrade, transform, and synthesize organic compounds as well as to the pathogenic effects that have been described in many case studies. The number of publications about Gordonia has increased significantly after the year 2004 (the year of the first Gordonia review published by Arenskötter et al.) describing 13 new validly published species (type strains), many newly described physiological and metabolic capabilities, new patent applications and many new case reports of bacterial infections. Members of the genus Gordonia are widely distributed in nature and it is therefore important to unravel the species richness and metabolic potential of gordoniae in future studies to demonstrate their environmental impact especially on the degradation of persistent organic compounds and their ecological participation in the carbon cycle of organic material in soil and water. This review summarizes mainly the current state of importance and potential of the members of this genus for the environmental and biotechnological industry ("the strengthsâ) and briefly its pathogenic impact to humans ("the weaknessesâ).
Assuntos
Infecções por Actinomycetales/microbiologia , Biotecnologia , Bactéria Gordonia/metabolismo , Bactéria Gordonia/patogenicidade , Poluentes Ambientais/metabolismo , Bactéria Gordonia/classificação , Bactéria Gordonia/genética , HumanosRESUMO
Gordonia species are aerobic Gram-positive bacilli and a rare cause of human disease. To our knowledge, there are only two cases of human infection with Gordonia sputi reported in the literature. We report five cases of bacteraemia due to Gordonia species at our institution since 2005, including four caused by G. sputi. Three of these cases were likely related to chronic indwelling central venous catheters.
Assuntos
Infecções por Actinomycetales/microbiologia , Bacteriemia/microbiologia , Infecção Hospitalar/microbiologia , Bactéria Gordonia/patogenicidade , Infecções por Actinomycetales/etiologia , Adulto , Idoso , Bacteriemia/etiologia , Infecções Relacionadas a Cateter/etiologia , Infecções Relacionadas a Cateter/microbiologia , Cateterismo Venoso Central/efeitos adversos , Infecção Hospitalar/etiologia , Feminino , Bactéria Gordonia/classificação , Bactéria Gordonia/genética , Bactéria Gordonia/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Cidade de Nova Iorque , Fatores de Risco , Especificidade da EspécieRESUMO
We report the first case of endocarditis caused by Gordonia polyisoprenivorans and concisely review the English literature regarding bloodstream infections caused by Gordonia species.