Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil
Nascimento, Valdinete Alves do; Corado, André de Lima Guerra; Nascimento, Fernanda Oliveira do; Costa, Ágatha Kelly Araújo da; Duarte, Debora Camila Gomes; Luz, Sérgio Luiz Bessa; Gonçalves, Luciana Mara Fé; Jesus, Michele Silva de; Costa, Cristiano Fernandes da; Departamento de BiologiaDelatorre, Edson; Naveca, Felipe Gomes.
Mem. Inst. Oswaldo Cruz
; 115: e200310, 2020. tab, graf
Artigo
em Inglês
| LILACS, SES-SP | ID: biblio-1135251
A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.
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BR1.1
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