Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 44(1): 74-80, Jan.-Feb. 2022. graf
Article
em En
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LILACS-Express
| LILACS
| ID: biblio-1360176
Biblioteca responsável:
BR1.1
ABSTRACT
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
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Project document