Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals
Clinics
; 77: 100107, 2022. tab
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1404330
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
This study aimed to evaluate the associations between Lipoprotein (a) ‒ Lp(a) levels and carotid Intima-Media Thickness (cIMT) and with carotid plaques in healthy subjects because of previous contradictory data.Methods:
A total of 317 healthy normolipidemic subjects (20‒77 years old) were selected. The cIMT and atherosclerotic plaques were determined by B-mode ultrasonography. Mann-Whitney tests were performed to compare the groups according to Lp(a) levels and to explore the associations between Lp(a), carotid plaques, and cIMT, logistic and linear regression analyses were performed.Results:
Studied population (51% females, median age 43 years old) presented carotid plaques and cIMT ≥ 0.9 mm in 23% and 18% of the participants, respectively. The group with Lp(a) levels > 30 mg/dL presented significantly higher age and atherosclerotic plaques. Indeed, multivariate linear regression analysis showed a significant association between Lp(a), age, and race. On the other hand, logistic regression analysis demonstrated that the subjects with Lp(a) > 30 mg/dL have a significantly high risk of carotid plaques.Conclusion:
The data from the present study indicate that Lp(a) levels above 30 mg/dL contribute to the development of carotid plaques even in apparently healthy participants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
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Project document