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Experimental studies using OMV in a new platform of SARS-CoV-2 vaccines
Gaspar, Emanuelle B; Prudencio, Carlos Roberto; Gaspari, Elizabeth De.
Afiliação
  • Gaspar, Emanuelle B; Animal Health Department, Embrapa Southern Region Animal Husbandry. Embrapa Southern Region Animal Husbandry. BR
  • Prudencio, Carlos Roberto; Department of Immunology. Adolfo Lutz Institute. BR
  • Gaspari, Elizabeth De; Department of Immunology. Adolfo Lutz Institute. BR
Article em En | LILACS, CONASS, ColecionaSUS, SES-SP, SESSP-IALPROD, SES-SP | ID: biblio-1417874
Biblioteca responsável: BR91.2
Localização: BR76.1; Digital
ABSTRACT
Although COVID-19 vaccines have recently been approved for emergency use, search for new vaccines are still urgent, since the access of the countries, especially the poorest, to the vaccines, has shown to be slower than the necessary to rapidly control the pandemic. We proposed a novel platform for vaccine using recombinant receptor binding domain (rRBD) from Sars-Cov-2 spike protein and Neisseria meningitidis outer membrane vesicles (OMVs). The antigen preparation produced a humoral and cellular immune response. Taken together our findings suggest a good immunostimulatory patter in response to immunization with rRBD plus N. meningitidis OMV.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: CONASS / LILACS / SES-SP / SESSP-IALPROD / ColecionaSUS Assunto principal: Vacinas contra COVID-19 / SARS-CoV-2 / Imunidade Celular / Antígenos / Neisseria meningitidis Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo: 1 Coleções: 01-internacional Base de dados: CONASS / LILACS / SES-SP / SESSP-IALPROD / ColecionaSUS Assunto principal: Vacinas contra COVID-19 / SARS-CoV-2 / Imunidade Celular / Antígenos / Neisseria meningitidis Idioma: En Ano de publicação: 2021 Tipo de documento: Article