Abstract In
HIV-
patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to
AIDS and non-
AIDS comorbidities, even during combined antiretroviral
therapy (cART). In this
cross-sectional study, we aimed to analyze some of these
parameters in 138 different asymptomatic
HIV-infected
patients, doing multiple comparisons between the groups, which are dichotomized in the presence / absence of cART and type of
immune response (immunological responders [iR,>500cells/mL] or non-responders [
iNR,<500cells/ mL]). Were analyzed
cytokines and other routine
laboratory parameters. Our results showed high
creatine phosphokinase and low
IL-10 levels in cART-
patients. They also presented metabolic alterations, including elevations in total
cholesterol and
triglycerides, particularly in those
iNR. In
ART-iR an increased
alanine aminotransferase was observed. Those NAÏVE-
iNR presented high LDL-
cholesterol,
C-reactive protein and
lactate dehydrogenase values. The
long-term non-progressors (LTNP) showed the best
laboratory results. In conclusion, many
blood parameters were changed in
HIV-
patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early
therapeutic onset.