SUMMARY
OBJECTIVE: This study aimed to verify
risk factors associated with
gastroschisis mortality in three
neonatal intensive care units located in the
state of Espírito Santo,
Brazil .
METHODS: A retrospective
cohort study of
neonates with
gastroschisis was performed between 2000 and 2018. Prenatal, perinatal, and postsurgical variables of
survival or nonsurvival groups were compared using chi-square statistical test, t-
test, Mann-Whitney U test, and
logistic regression . Tests with p<0.05 were considered statistically determined.
RESULTS: A total of 142
newborns were investigated. Mean
maternal age ,
gestational age , and
birth weight were lower in the group of nonsurvival (p<0.05). Poor clinical conditions during admission, complex
gastroschisis , closure with silo placement, the use of
blood products, surgical
complications , and
short bowel syndrome were more frequent in the nonsurvival group (p<0.05). Complex
gastroschisis [adjusted
odds ratio (OR) 3.74, 95%
confidence interval (95%CI) 1.274-11.019] and
short bowel syndrome (adjusted OR 7.55, 95%CI 2.177-26.225) increased the
risk of
death . Higher
birth weight inversely reduced the
risk for
mortality (adjusted OR 0.99, 95%CI 0.997-1.000).
CONCLUSION: Complex
gastroschisis and
short bowel syndrome increased the
risk of
death , with greater
birth weight being inversely correlated with the
risk of
mortality . The findings of this
research can contribute to the formulation of
protocols to improve the quality and
safety of care in order to reduce
neonatal mortality associated with
gastroschisis .