Anti-proliferative or Cytopathic Potential of Thapsia garganica, Citrus sinensis, Citrus limon and Vinca rosea Extracts Against Human Embryonic Kidney Carcinoma Cell Line
West Indian med. j
; 69(5): 309-314, 2021. tab
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1515678
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Objective:
Developing anti-cancer drugs from natural products is receiving increasing interest worldwide due to limitations and side effects of anti-cancer drugs. The purpose of this study was to explore the anti-proliferative or cytopathic potential of natural compounds derived from plant sources as alternatives of synthetic compounds on human embryonic kidney carcinoma (HEK) cell line.Methods:
In this study, aqueous and methanolic extracts were obtained from various plants, viz, Thapsia garganica, Citrus sinesis, Citrus limon and Vinca rosea. Extracts were serially diluted into 96-well microtitre plates and were screened for anti-proliferative potential against the HEK cell line via the neutral red dye uptake assay.Results:
The findings revealed that methanolic extracts of T. garganica leaf and V. rosea leaf were the most effective as anti-proliferative or cytotoxic against the HEK cell line, with IC50 at 32-fold dilution of the extract.Conclusion:
The extracts of T. garganic and V, rosea have been used as anti-proliferative drugs but after trial in experimental animals for being not toxic.
Texto completo:
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Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article