Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais
Godin, Mariana Martins; Souza, Lucas de Oliveira; Schmidt, Luciana Cayres; Vieira, Lauro Mello; Diniz, Rejane Silva; Dusse, Luci Maria SantAna.
Rev. bras. hematol. hemoter
; 38(3): 193-198, 2016. tabela, gráfico
Artigo
em Inglês
| LILACS | ID: biblio-834154
Background:
The term dangerous universal blood donor refers to potential agglutination of the erythrocytes of non-O recipients due to plasma of an O blood group donor, which contains high titers of anti-A and/or anti-B hemagglutinins. Thus, prior titration of anti-A and anti-B hemagglutinins is recommended to prevent transfusion reactions.Objective:
The aim ofthis study was to estimate the frequency of dangerous universal donors in the blood bank of Belo Horizonte (Fundac¸ão Central de Imuno-Hematologia Fundac¸ão Hemominas Minas Gerais) by determining the titers of anti-A and anti-B hemagglutinins in O blood group donors.Method:
A total of 400 O blood group donors were randomly selected, from March 2014 to January 2015. The titers of anti-A and anti-B hemagglutinins (IgM and IgG classes) were obtained using the tube titration technique. Dangerous donors were those whose titers of anti-A or anti-B IgM were ≥128 and/or the titers of anti-A or anti-B IgG were ≥256. Donors were characterized according to gender, age and ethnicity. The hemagglutinins were characterized by specificity (anti-A and anti-B) and antibody class (IgG and IgM).Results:
Almost one-third (30.5%) of the O blood group donors were universal dangerous. The frequency among women was higher than that of men (p-value = 0.019; odds ratio 1.66; 95% confidence interval 1.082.56) and among young donors (1829 years old) it was higher than for donors between 49 and 59 years old (p-value = 0.015; odds ratio 3.05; 95% confi- dence interval 1.227.69). There was no significant association between dangerous universal donors and ethnicity, agglutinin specificity or antibody class.Conclusion:
Especially platelet concentrates obtained by apheresis (that contain a substantial volume of plasma), coming from dangerous universal donors should be transfused in isogroup recipients whenever possible in order to prevent the occurrence of transfusion reactions
Biblioteca responsável:
BR408.1
Localização: BR408.1
Texto completo
Documentos relacionados