Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Acta cir. bras
; 33(5): 420-430, May 2018. tab, graf
Article
em En
| LILACS
| ID: biblio-949349
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant.Methods:
Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV red propolis 100 mg/kg, GII and GVI celecoxib 20 mg/kg, GIII and GVII 1% gum arabic 5 mL/kg, GIV and GVIII distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E).Results:
In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001).Conclusion:
Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Própole
/
Próteses e Implantes
/
Tampões de Gaze Cirúrgicos
/
Inflamação
/
Neovascularização Patológica
Tipo de estudo:
Qualitative_research
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article