Use of PCR for the determination of the frequency of the F508 mutation in Brasilian cistic fibrosis patients
Mem. Inst. Oswaldo Cruz
; 88(2): 309-12, abr.-jun. 1993.
Article
em En
| LILACS
| ID: lil-119495
Biblioteca responsável:
BR15.1
RESUMO
The F508 mutation in the cystic fibrosis (CF) gene was studied in a population of 18 Brazilian CF patients and their 17 families by use of PCR and differential hybridization with oligonucleotides. In a total of 34 chromosomes considered, 12 (35%) carried the F508 deletion, a frequency much lower than that reported in most other populations. As a consequence, CF in Brazil would be predominantly caused by mutations different from the F508 deletion
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Engenharia Genética
/
Fibrose Cística
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article