Dietary sodium intake and cardiac nerve cell hypertrophy in Wistar rats
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;29(3): 363-5, Mar. 1996. ilus, graf
Article
em En
| LILACS
| ID: lil-163845
Biblioteca responsável:
BR1.1
ABSTRACT
We determined the effect of dietary sodium intake (0.15 and 8 per cent NACl) on the cardiac neuron size of normotensive 3-week old Wistar rats. An increase in dietary sodium for 48 weeks induced an increase in neuronal size. The number of large neurons (larger than 500 muM2) increased significantly (chi-square test) in rats ingesting 8 per cent NaCl in their food. The rats presented hypertension (128 ñ 9 vs 134 ñ 16 mmHg; difference not significant, Student t-test) and a statistically significant increase in cardiac muscle mass (1.6 ñ 0.1 vs 2.0 ñ 0.2 mg/g of rat). We conclude that food sodium can significantly increase cardiac nerve cell size and this trophic response occurs concomitantly with an increase of cardiac muscle mass.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Sódio na Dieta
/
Cardiomegalia
/
Hipertensão
/
Neurônios
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article