Chronic myeloid leukemia (CML): prognostic factors and survival analysis
São Paulo med. j
; 114(1): 1083-1090, Jan.-Feb. 1996. tab, graf
Article
em En
| LILACS
| ID: lil-173538
Biblioteca responsável:
BR1.1
ABSTRACT
The prognostic value of different factors upon diagnosis of CML was analysed in 45 Philadelphia (Ph1)-positive patients. The median survival was 48 months. Univariate analysis showed 5 poor prognostic factors (male sex, under 45 years-old, bone marrow blasts greater than or equal to 10 percent, blood basophils greater than or equal to 6 percent and blood eosinophilis greater than or equal to 6 percent) which provided for the development of a clinical staging system Stage I whith none or one factor and a two-year survival rate of 100 percent; Stage II with two or three factors and two-year survival of 72.2 percent; and Stage III with four or five factors and two-year survival of 0 percent (p=0.00016). Multivariate survival analysis showed that combination of blood basophilia and bone marrow blasts had the strongest predective relationship to survival time. We conclude that a combination of pretreatment factors identifies different risk subcategories in CML patients and is helpful in assessing the overall prognosis and the treatment approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Basófilos
/
Medula Óssea
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Eosinófilos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article