Avaliaçäo do marcador de hipercoagulabilidade fragmento 1+2 da protrombina, em pacientes portadores de próteses cardíacas mecânicas ou biológicas / Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses
Arq. bras. cardiol
; 79(5): 500-509, nov. 2002. tab
Article
em Pt, En
| LILACS
| ID: lil-325521
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE - To investigate whether patients with heart valve prostheses and similar International Normalized Ratios (INR) have the same level of protection against thromboembolic events, that is, whether the anticoagulation intensity is related to the intensity of hypercoagulability supression. METHODS - INR and plasma levels of prothrombin fragment 1+2 (F1+2) were assessed in blood samples of 27 patients (7 with mechanical heart valves and 20 with biological heart valves) and 27 blood samples from healthy donors that were not taking any medication. RESULTS - Increased levels of F1+2 were observed in blood samples of 5 patients with heart valve prostheses taking warfarin. These findings reinforce the idea that even though patients may have INRs, within the therapeutic spectrum, they are not free from new thromboembolic events. CONCLUSION - Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Bioprótese
/
Protrombina
/
Próteses Valvulares Cardíacas
/
Trombofilia
Tipo de estudo:
Evaluation_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
/
Pt
Ano de publicação:
2002
Tipo de documento:
Article