Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Mem. Inst. Oswaldo Cruz
; 102(3): 417-420, June 2007. tab
Article
em En
| LILACS
| ID: lil-452507
Biblioteca responsável:
BR1.1
ABSTRACT
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Proteínas de Membrana Transportadoras
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Proteínas de Protozoários
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Cloroquina
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Clorfeniramina
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Malária Falciparum
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Amodiaquina
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Antagonistas dos Receptores Histamínicos H1
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Antimaláricos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article