Imunodepressão induzida por talidomida e ciclosporina em transplante cardíaco heterotópico de coelho / Imunodeppression induced by thalidomide and cyclosporine in heterotopic heart transplantation of rabbits
Foram utilizados 50 coelhos, sendo 25 doadores e 25 receptores.Os animais receptores foram subdivididos em cinco grupos (n= 5) Grupo I (controle) animais não-imunodeprimidos; Grupo II (imunodeprimidos com ciclosporina na dose de 10 mg/kg/dia); Grupo III (imunodeprimidos com talidomida na dose de 100 mg/kg/dia); Grupo IV (imunodeprimidos com ciclosporina na dose de 5,0 mg/kg/dia) e Grupo V (imunodeprimidos com ciclosporina na dose de 5,0 mg/kg/dia associada a talidomida na dose de 50 mg/kg/dia). Os medicamentos foram administrados através de cateter orogástrico, a partir do dia anterior ao transplante.
A talidomida empregada isoladamente, ou associada à ciclosporina, pode representar uma opção de imunodepressão em transplantes cardíaco heterotópico experimental de coelho.
Fifty rabbits were used, 25 of them as donors and 25 as recipients. Recipient animals were divided into five groups (n = 5 each) Group I (control) _ non-immunodepressed animals, Group II (immunodepressed animals with cyclosporine at the dose of 10 mg/kg/day), Group III ( immunodepressed animals with thalidomide at the dose of 100 mg/kg/day), Group IV ( immunodepressed animals with cyclosporine at the dose of 5.0 mg/kg/day ), and Group V ( immunodepressed animals with cyclosporine at the dose of 5.0 mg/kg/day in combination with thalidomide at the dose of 50 mg/kg/day). Medications were administered through an orogastric catheter starting on the day before the transplant. The heart of the donors was implanted in the abdomen of the recipients.
RESULTS:
The combination of thalidomide and cyclosporine showed the lowest histopathological rejection score (p < 0.05). Thalidomide administered alone or in combination with cyclosporine was effective against rejection, significantly increasing the survival (p < 0.01) of animals submitted to heterotopic heart transplantation in the abdominal position.