Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.
Fernandes, Francis Rigolo; Santos, André Luis dos; Arruda, Ana Maria Soares de; Vasques-Pinto, Luciana de Miranda C; Godinho, Rosely Oliveira; Torres, Luce Maria Brandão; Lapa, Antonio José; Souccar, Caden.
Rev. bras. farmacogn
; 12(supl.1): 55-56, 2002. ilus
Artigo
em Inglês
| LILACS | ID: lil-528750
The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50 percent and by 46 to 70 percent of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.
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