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The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice
Miguel, Danilo Ciccone; Ferraz, Marcela Lencine; Alves, Rosana de Oliveira; Yokoyama-Yasunaka, Jenicer KU; Torrecilhas, Ana Claudia; Romanha, Alvaro José; Uliana, Silvia RB.
Afiliação
  • Miguel, Danilo Ciccone; s.af
  • Ferraz, Marcela Lencine; s.af
  • Alves, Rosana de Oliveira; s.af
  • Yokoyama-Yasunaka, Jenicer KU; s.af
  • Torrecilhas, Ana Claudia; s.af
  • Romanha, Alvaro José; s.af
  • Uliana, Silvia RB; s.af
Mem. Inst. Oswaldo Cruz ; 105(7): 945-948, Nov. 2010. graf, tab
Article em En | LILACS | ID: lil-566191
Biblioteca responsável: BR1.1
ABSTRACT
The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tamoxifeno / Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tamoxifeno / Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article