El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía / Tumor necrosis factor-alpha and interleukin-6 levels among patients suffering a bile duct injury during cholecystectomy
MIRANDA-DÍAZ, ALEJANDRA G; HERMOSILLO-SANDOVAL, JOSÉ M; HUERTA-ROSAS, GONZALO; LÓPEZ-GUILLÉN, GERMÁN G; CARDONA MUÑOZ, ERNESTO G; GARCÍA-IGLESIAS, TRINIDAD; PACHECO-MOISÉS, FERMÍN; ALATORRE-CARRANZA, MARÍA DEL P.
Rev. méd. Chile
; 138(10): 1259-1263, oct. 2010. graf
Artigo
em Espanhol
| LILACS | ID: lil-572937
Background:
During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic productsAim:
To measure serum levels of TNF-α and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients andMethods:
Serum levels of TNF-α and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls.Results:
At baseline TNF-α levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-á became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients.Conclusions:
TNF-α and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.
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