Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén / Association between adiponectin gene polymorphisms and obesity in school age children from Hualpén, Chile
Rev. méd. Chile
; 140(10): 1245-1252, oct. 2012. ilus, tab
Article
em Es
| LILACS
| ID: lil-668696
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities.Aim:
To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population. Material andMethods:
A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing.Results:
The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval 1.001-1.929,p = 0.049).Conclusions:
Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Estado Nutricional
/
Polimorfismo de Nucleotídeo Único
/
Adiponectina
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
País/Região como assunto:
America do sul
/
Chile
Idioma:
Es
Ano de publicação:
2012
Tipo de documento:
Article
/
Project document