Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients
Dinardo, Carla Luana; Ito, Glaucia Munemasa; Sampaio, Luciana Ribeiro; Mendrone Junior, Alfredo.
Rev. bras. hematol. hemoter
; 35(6): 414-416, 2013. tab, graf
Artigo
em Inglês
| LILACS | ID: lil-699991
Background:
The inflammatory background of patients influences the process of alloimmunization against red blood cell antigens. Proof of this statement to clinical practice is still lacking.Objective:
The aim of this study was to verify whether factors related to disease severity and inflammatory status of cancer patients can predict alloimmunization.Methods:
This was a case-control study in which alloimmunized oncologic patients treated between 2009 and 2012 were compared with a non-alloimmunized control group regarding the severity of the disease (metastasis/performance status/body mass index) and C-reactive protein levels.Results:
The groups did not differ significantly in terms of C-reactive protein, Eastern Cooperative Oncology Group (ECOG)/Karnofsky performance status, presence of metastasis and body mass index.Conclusion:
It is not possible to predict alloimmunization in cancer patients based on severity of illness and inflammatory markers. Strategies of screening patients by phenotyping blood based on these criteria are not justified. .
Biblioteca responsável:
BR408.1
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