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Prophylactic strategies for acute hemolysis secondary to plasma-incompatible platelet transfusions: correlation between qualitative hemolysin test and isohemagglutinin titration
Landim, Cinthia Silvestre; Gomes, Francisco Carlos Almeida; Zeza, Bernardete Martin; Mendrone-Júnior, Alfredo; Dinardo, Carla Luana.
Afiliação
  • Landim, Cinthia Silvestre; Fundação Pró-Sangue. Hemocentro de São Paulo. São Paulo. BR
  • Gomes, Francisco Carlos Almeida; Fundação Pró-Sangue. Hemocentro de São Paulo. São Paulo. BR
  • Zeza, Bernardete Martin; Fundação Pró-Sangue. Hemocentro de São Paulo. São Paulo. BR
  • Mendrone-Júnior, Alfredo; Fundação Pró-Sangue. Hemocentro de São Paulo. São Paulo. BR
  • Dinardo, Carla Luana; Fundação Pró-Sangue. Hemocentro de São Paulo. São Paulo. BR
Rev. bras. hematol. hemoter ; 37(4): 217-222, July-Aug. 2015. tab, ilus
Article em En | LILACS | ID: lil-756568
Biblioteca responsável: BR408.1
ABSTRACT
Brazilian legislation has recently suggested the use of the qualitative hemolysin test instead of isohemagglutinin titers as prophylaxis for acute hemolysis related to plasma-incompatible platelet transfusions. The efficacy of this test in preventing hemolytic reactions has never been evaluated while isohemagglutinin titers have been extensively studied. The main objective of this study was to evaluate the correlation between the results of these two tests. The impact of each type of prophylaxis on the platelet inventory management and the ability of the qualitative hemolysin test to prevent red cell sensitization after the transfusion of incompatible units were also studied.

METHODS:

A total of 246 donor blood samples were evaluated using both isohemagglutinin titers and the qualitative hemolysin test, and the results were statistically compared. Subsequently, 600 platelet units were tested using the hemolysin assay and the percentage of units unsuitable for transfusion was compared to historical data using isohemagglutinin titers (cut-off 100). Moreover, ten patients who received units with minor ABO incompatibilities that were negative for hemolysis according to the qualitative hemolysin test were evaluated regarding the development of hemolysis and red cell sensitization (anti-A or anti-B).

RESULTS:

Isohemagglutinin titration and the results of qualitative hemolysin test did not correlate. The routine implementation of the qualitative hemolysin test significantly increased the percentage of platelet units found unsuitable for transfusions (15-65%; p-value <0.001)...
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Incompatibilidade de Grupos Sanguíneos / Sistema ABO de Grupos Sanguíneos / Transfusão de Plaquetas / Proteínas Hemolisinas / Hemólise Tipo de estudo: Qualitative_research Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Incompatibilidade de Grupos Sanguíneos / Sistema ABO de Grupos Sanguíneos / Transfusão de Plaquetas / Proteínas Hemolisinas / Hemólise Tipo de estudo: Qualitative_research Idioma: En Ano de publicação: 2015 Tipo de documento: Article