Cyclooxygenase-dependent signalling: molecular events and consequences.
FEBS Lett
; 445(1): 1-5, 1999 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-10069362
ABSTRACT
Non-steroidal anti-inflammatory drugs (NSAIDs) currently attract large interest. Next to pain relief, NSAIDs have important anti-thrombotic and anti-oncogenic effects. NSAIDs exert their action by inhibition of cyclooxygenase, the enzyme responsible for the production of prostanoids. Prostanoid signal transduction is still poorly understood, but it has become clear that these inflammatory lipids influence cellular physiology at three different levels (1) activation of a 7 x transmembrane receptor coupled to heterotrimeric G proteins, (2) the inhibition of inflammation by activating corticosteroid-like receptors, (3) participation in receptor protein tyrosine kinase signal transduction. In this review prostanoid signalling at these three different levels will be reviewed and the relevance in (patho)physiological processes will be evaluated.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Prostaglandina-Endoperóxido Sintases
Limite:
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article