Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis.
J Am Acad Dermatol
; 40(4): 577-82, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10188677
ABSTRACT
BACKGROUND:
Extracorporeal photochemotherapy (ECP) using UVA irradiation of enriched leukocytes in the presence of methoxsalen as a photoactivatable substrate has been employed for the treatment of several immunologically mediated disorders.OBJECTIVE:
Our purpose was to determine the efficacy and safety of long-term ECP in the treatment of severe atopic dermatitis.METHODS:
Fourteen patients with severe recalcitrant atopic dermatitis were treated with ECP in an open clinical trial at 2-week intervals. Disease activity was scored before each ECP cycle by means of a standardized protocol.RESULTS:
A complete clinical remission was achieved in 4 patients (29%). Five patients (36%) experienced a substantial response with reduction of skin inflammation by at least 75%, whereas in one patient (7%) disease activity was reduced by more than 50%. Four patients were withdrawn from the study for unresponsiveness. No clinical signs of immunosuppression or other severe adverse events became evident.CONCLUSION:
Long-term ECP may have significant beneficial effects on the course of atopic dermatitis and should therefore be considered as a treatment modality for patients suffering from severe and otherwise refractory atopic skin disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia PUVA
/
Dermatite Atópica
/
Circulação Extracorpórea
/
Leucócitos
Tipo de estudo:
Guideline
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article