A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus.
Neuropharmacology
; 38(4): 605-8, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10221764
ABSTRACT
We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (R,S)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+/calmodulin-dependent protein kinases (CaMKs), including CaMKII.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
1-(5-Isoquinolinasulfonil)-2-Metilpiperazina
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Inibidores Enzimáticos
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Hipocampo
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Metoxi-Hidroxifenilglicol
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article