External radioactive reference markers in SPECT imaging of the dopamine system.
J Nucl Med Technol
; 27(2): 112-6, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10353107
ABSTRACT
OBJECTIVE:
External radioactive reference markers have been used to localize the canthomeatal (CM) line and correct for head rotation in perfusion brain SPECT. This ensures that regardless of the subject's head position or rotation under the SPECT camera, reconstructed transaxial slices are reoriented parallel to the CM line. This study was undertaken to demonstrate the value of external radioactive reference markers in dopamine SPECT imaging.METHODS:
We compared visual and marker methods of reorienting the transaxial slices between dopamine and perfusion brain SPECT studies, respectively. These consisted of imaging normal controls and patients with Alzheimer's or Parkinson's disease using a triple-head camera. Intra- and interoperator variability of the visual and marker methods of reorientation was determined for both perfusion and dopamine studies.RESULTS:
In both intra- and interoperator studies, the variability of image reorientation was significantly reduced (P = 0.0066 and 0.014, respectively) by using the marker method on dopamine images. The variability of reorientation using the marker method for a single operator with dopamine images was 3.0% coefficient of variation (CV), and for the interoperator study (5 different operators) this was 7.0% CV.CONCLUSION:
This study demonstrated that SPECT imaging of the dopamine system with external radioactive reference markers significantly reduced the variability of determining the angle of reorientation. This resulted in a standardized and consistent method of reorienting transaxial slices, allowing comparison within and between subjects of pre- and postsynaptic dopamine SPECT studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Proteínas de Membrana Transportadoras
/
Encéfalo
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Receptores Dopaminérgicos
/
Doença de Alzheimer
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article