High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats.
Eur J Pharmacol
; 376(3): 217-22, 1999 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-10448879
ABSTRACT
Antioxidants can improve nerve dysfunction in hyperglycaemic rats. We evaluated whether the standard supplementation of rat food with vitamin E (normally added for preservation purposes) or high-dose vitamin E treatment improves nerve conduction in maturing streptozotocin-diabetic rats, a model widely used to study diabetic neuropathy. Hyperglycaemic rats received food containing 25 mg/kg (non-supplemented), 70 mg/kg (standard food) or 12 g/kg (high-dose) vitamin E. Non-diabetic controls received non-supplemented food. Sciatic and tibial sensory and motor nerve conduction velocity were decreased in all diabetic animals. In comparison with standard feeding, the non-supplemented diabetic rats showed lower plasma vitamin E levels but no significant change in nerve conduction. High-dose treatment prevented nerve dysfunction by 50%, and led to attenuated endoneurial lipid peroxidation (measured as malondialdehyde). We conclude that high doses of vitamin E, but not standard vitamin E supplementation of rat food partially prevent nerve dysfunction in young adult streptozotocin-diabetic rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Alimentos Fortificados
/
Diabetes Mellitus Experimental
/
Neuropatias Diabéticas
/
Condução Nervosa
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Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article