GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.
Neuron
; 23(4): 725-36, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10482239
ABSTRACT
GFR alpha3 is a component of the receptor for the neurotrophic factor artemin. The role of GFR alpha3 in nervous system development was examined by generating mice in which the Gfr alpha3 gene was disrupted. The Gfr alpha3-/- mice exhibited severe defects in the superior cervical ganglion (SCG), whereas other ganglia appeared normal. SCG precursor cells in the mutant embryos failed to migrate to the correct position, and they subsequently failed to innervate the target organs. In wild-type embryos, Gfr alpha3 was expressed in migrating SCG precursors, and artemin was expressed in and near the SCG. After birth, SCG neurons in the mutant mice underwent progressive cell death. These observations suggest that GFR alpha3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Proteínas Proto-Oncogênicas
/
Receptores de Fator de Crescimento Neural
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Gânglio Cervical Superior
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Receptores Proteína Tirosina Quinases
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Proteínas de Drosophila
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Fatores de Crescimento Neural
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Proteínas do Tecido Nervoso
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article